Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Bronwyn M Kivell"'
Autor:
Katharina Robichon, Rabia Bibi, Mackenzie Kiernan, Lisa Denny, Thomas E Prisinzano, Bronwyn M Kivell, Anne Camille La Flamme
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 12, Pp n/a-n/a (2023)
Abstract Objectives Multiple sclerosis (MS) is a neurodegenerative disease characterised by inflammation and damage to myelin sheaths. While all current disease‐modifying treatments (DMTs) are very effective at reducing relapses, they do not slow t
Externí odkaz:
https://doaj.org/article/fbeca3f8b076416d96fc9ca8b16c2612
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139829 (2015)
Methamphetamine is a widely abused, highly addictive drug. Regulation of synaptic proteins within the brain's reward pathway modulates addiction behaviours, the progression of drug addiction and long-term changes in brain structure and function that
Externí odkaz:
https://doaj.org/article/8b8093117c42485a92db86cdcf073c7c
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Chemotherapy-induced neuropathic pain is a common side effect for cancer patients which has limited effective treatment options. Kappa opioid receptor (KOR) agonists are a promising alternative to currently available opioid drugs due to their low abu
Externí odkaz:
https://doaj.org/article/97d79a71d1e943a19ad6b16a219e6b6f
Autor:
Kelly F. Paton, Katharina Robichon, Nikki Templeton, Lisa Denny, Afnan Al Abadey, Dan Luo, Thomas E. Prisinzano, Anne C. La Flamme, Bronwyn M. Kivell
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Multiple sclerosis is a neurodegenerative disease associated with demyelination and neuroinflammation in the central nervous system. There is an urgent need to develop remyelinating therapies to better treat multiple sclerosis and other demyelinating
Externí odkaz:
https://doaj.org/article/39b6ddc719c14ca4983202a608459a81
Autor:
Kelly F. Paton, Andrew Biggerstaff, Sophia Kaska, Rachel S. Crowley, Anne C. La Flamme, Thomas E. Prisinzano, Bronwyn M. Kivell
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
In the search for safer, non-addictive analgesics, kappa opioid receptor (KOPr) agonists are a potential target, as unlike mu-opioid analgesics, they do not have abuse potential. Salvinorin A (SalA) is a potent and selective KOPr agonist, however, cl
Externí odkaz:
https://doaj.org/article/b9f4351e6b5d472db7d619fb7f810bd9
Autor:
Bronwyn M. Kivell, Shainnel O. Eans, Abdullah Allaoa, András Váradi, Lisa L. Wilson, Gavril W. Pasternak, Rajendra Uprety, Andrew C. Kruegel, John E. Pintar, Xiaohai Li, Samuel T. Slocum, Takeshi Irie, Jay P. McLaughlin, Brittany Scouller, Amy F. Alder, Michael D. Cameron, Sanjay Kalra, Ying-Xian Pan, Amanda Hunkele, Susruta Majumdar, Michael Ansonoff, Valerie Le Rouzic, Dalibor Sames, Soumen Chakraborty, Jin Xu
Publikováno v:
J Med Chem
The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of natural products chemistry, chemical synthesis, and pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c5e470bfb54471841442c42450dcbe
https://doi.org/10.1021/acs.jmedchem.1c01111
https://doi.org/10.1021/acs.jmedchem.1c01111
Publikováno v:
Brain Sciences; Volume 12; Issue 12; Pages: 1687
Multiple sclerosis is an autoimmune disease characterised by demyelination in the central nervous system. The cuprizone-induced demyelination model is often used in mice to test novel treatments for multiple sclerosis. However, despite significant de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827659c705adf24643544f6bb023bee5
Strategies for DevelopingκOpioid Receptor Agonists for the Treatment of Pain with Fewer Side Effects
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 375:332-348
There is significant need to find effective, nonaddictive pain medications. κ Opioid receptor (KOPr) agonists have been studied for decades but have recently received increased attention because of their analgesic effects and lack of abuse potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb2029ce838f45af4c6004925476a1a3
https://doi.org/10.1124/jpet.120.000134
https://doi.org/10.1124/jpet.120.000134
Publikováno v:
Frontiers in pharmacology. 13
Kappa-opioid receptors (KOR) are widely expressed throughout the central nervous system, where they modulate a range of physiological processes depending on their location, including stress, mood, reward, pain, inflammation, and remyelination. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb81cdc278c13ee9b8c5633c88073425
https://pubmed.ncbi.nlm.nih.gov/35795569
https://pubmed.ncbi.nlm.nih.gov/35795569
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Chemotherapy-induced neuropathic pain is a common side effect for cancer patients which has limited effective treatment options. Kappa opioid receptor (KOR) agonists are a promising alternative to currently available opioid drugs due to their low abu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d800d93eee09d748099c0c90ffd7896
https://pubmed.ncbi.nlm.nih.gov/35250563
https://pubmed.ncbi.nlm.nih.gov/35250563