Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Bronwyn A. Evans"'
Autor:
Seungmin Ham, Saori Mukaida, Masaaki Sato, Peter Keov, Tore Bengtsson, Sebastian Furness, Nicholas D. Holliday, Bronwyn A. Evans, Roger J. Summers, Dana S. Hutchinson
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract Truncation of the C‐terminal tail of the β2‐AR, transfection of βARKct or over‐expression of a kinase‐dead GRK mutant reduces isoprenaline‐stimulated glucose uptake, indicating that GRK is important for this response. We explored
Externí odkaz:
https://doaj.org/article/8b05f72e8cfe40dba5549ad1377f554f
Autor:
Jon Merlin, Masaaki Sato, Ling Yeong Chia, Richard Fahey, Mohsen Pakzad, Cameron J. Nowell, Roger J. Summers, Tore Bengtsson, Bronwyn A. Evans, Dana S. Hutchinson
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
The recruitment of brite (or beige) adipocytes has been advocated as a means to combat obesity, due to their ability to phenotypically resemble brown adipocytes (BA). Lineage studies indicate that brite adipocytes are formed by differentiation of pre
Externí odkaz:
https://doaj.org/article/a80447254c064d2f83c945b0dc6c8d05
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 393:141-146
β3-Adrenoceptors exhibit a restricted expression pattern, particularly in humans. However, they have been found to be upregulated in various cancers and under several conditions associated with hypoperfusion such as congestive heart failure and diab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73147604fa34a1f88c778ccc90f424f
https://doi.org/10.1007/s00210-019-01780-6
https://doi.org/10.1007/s00210-019-01780-6
Autor:
Michelle L. Halls, Anna L. Sandström, Dana S. Hutchinson, Masaaki Sato, Nodi Dehvari, Jon Merlin, Robert I. Csikasz, Roger J. Summers, Anette I. Öberg, Saori Mukaida, Jessica M. Olsen, Tore Bengtsson, Bronwyn A Evans, Martina Kocan
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 316:R666-R677
The type 2 diabetes epidemic makes it important to find insulin-independent ways to improve glucose homeostasis. This study examines the mechanisms activated by a dual β2-/β3-adrenoceptor agonist, BRL37344, to increase glucose uptake in skeletal mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cce902b49b1e97999ef4d5f359cf2429
https://doi.org/10.1152/ajpregu.00285.2018
https://doi.org/10.1152/ajpregu.00285.2018
Autor:
Arhamatoulaye Maïga, Jon Merlin, Elodie Marcon, Céline Rouget, Maud Larregola, Bernard Gilquin, Carole Fruchart-Gaillard, Evelyne Lajeunesse, Charles Marchetti, Alain Lorphelin, Laurent Bellanger, Roger J Summers, Dana S Hutchinson, Bronwyn A Evans, Denis Servent, Nicolas Gilles
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68841 (2013)
ρ-Da1a is a three-finger fold toxin from green mamba venom that is highly selective for the α1A-adrenoceptor. This toxin has atypical pharmacological properties, including incomplete inhibition of (3)H-prazosin or (125)I-HEAT binding and insurmount
Externí odkaz:
https://doaj.org/article/ea1b5de2a53b4c798bdec40a54b07f16
Autor:
Masaaki Sato, Lynda Whiting, Dana S. Hutchinson, Seungmin Ham, Denise Wootten, Tore Bengtsson, Anastasia V. Kalinovich, Ling Yeong Chia, Saori Mukaida, Bronwyn A Evans, Nodi Dehvari, Jon Merlin, Huong T. M. Nguyen, Muhammad Hamza Bokhari, Roger J. Summers, Jie Gao
Publikováno v:
Pharmacology Research & Perspectives. 8
The β3 -adrenoceptor agonist mirabegron is approved for use for overactive bladder and has been purported to be useful in the treatment of obesity-related metabolic diseases in humans, including those involving disturbances of glucose homeostasis. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50ce9dfacc27ed681b7a70c8a831cf2
https://doi.org/10.1002/prp2.643
https://doi.org/10.1002/prp2.643
Autor:
Nodi, Dehvari, Masaaki, Sato, Muhammad Hamza, Bokhari, Anastasia, Kalinovich, Seungmin, Ham, Jie, Gao, Huong T M, Nguyen, Lynda, Whiting, Saori, Mukaida, Jon, Merlin, Ling Yeong, Chia, Denise, Wootten, Roger J, Summers, Bronwyn A, Evans, Tore, Bengtsson, Dana S, Hutchinson
Publikováno v:
Pharmacology Research & Perspectives
The β3‐adrenoceptor agonist mirabegron is approved for use for overactive bladder and has been purported to be useful in the treatment of obesity‐related metabolic diseases in humans, including those involving disturbances of glucose homeostasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7272eca386777e4f52843297d3834f47
https://pubmed.ncbi.nlm.nih.gov/32813332
https://pubmed.ncbi.nlm.nih.gov/32813332
Autor:
Bronwyn A Evans, Ross A. D. Bathgate, Martina Kocan, Daniel P. Poole, Romke Bron, Sheng Y. Ang, Roger J. Summers, Jesse J. DiCello, Dana S. Hutchinson
Publikováno v:
Journal of Molecular Endocrinology. 60:213-224
Insulin-like peptide 5 (INSL5) is a newly discovered gut hormone expressed in colonic enteroendocrine L-cells but little is known about its biological function. Here, we show using RT-qPCR and in situ hybridisation that Insl5 mRNA is highly expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82e7e254492940585ef25b625c1b866
https://doi.org/10.1530/jme-17-0152
https://doi.org/10.1530/jme-17-0152
Autor:
Dana S. Hutchinson, Edilson Dantas da Silva Júnior, Bronwyn A Evans, Masaaki Sato, Natalie Broxton, Roger J. Summers, Sabatino Ventura, Jon Merlin
Publikováno v:
British Journal of Pharmacology. 174:2318-2333
Background and Purpose Agonists acting at GPCRs promote biased signalling via Gα or Gβγ subunits, GPCR kinases and β-arrestins. Since the demonstration of biased agonism has implications for drug discovery, it is essential to consider confounding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e447ecaaa67649302df891e10fdeda5a
https://doi.org/10.1111/bph.13837
https://doi.org/10.1111/bph.13837
Publikováno v:
Pharmacological Research. 116:87-92
Uptake of glucose into skeletal muscle and adipose tissue plays a vital role in metabolism and energy balance. Insulin released from β-islet cells of the pancreas promotes glucose uptake in these target tissues by stimulating translocation of GLUT4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df976e2435068886f29859233c8e0b5
https://doi.org/10.1016/j.phrs.2016.12.022
https://doi.org/10.1016/j.phrs.2016.12.022