Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Bronwen R Burton"'
Autor:
Tianqi Lu, Zafar I. Bashir, Alessia Dalceggio, Caroline M. McKinnon, Lydia Miles, Amy Mosley, Bronwen R. Burton, Alice Robson
Publikováno v:
FEBS Open Bio, Vol 14, Iss 11, Pp 1762-1778 (2024)
To date, most efforts to decolonise curricula have focussed on the arts and humanities, with many believing that science subjects are objective, unbiased, and unaffected by colonial legacies. However, science is shaped by both contemporary and histor
Externí odkaz:
https://doaj.org/article/0f376ebf4bb849ac8620dbcd6b0d038f
Autor:
Bronwen R Burton, Richard K Tennant, John Love, Richard W Titball, David C Wraith, Harry N White
Publikováno v:
eLife, Vol 7 (2018)
Vaccines induce memory B-cells that provide high affinity secondary antibody responses to identical antigens. Memory B-cells can also re-instigate affinity maturation, but how this happens against antigenic variants is poorly understood despite its p
Externí odkaz:
https://doaj.org/article/7ff664d7460643c98acaea77787e8bda
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171547 (2017)
Secretion of interleukin-10 (IL-10) by CD4+ T cells is an essential immunoregulatory mechanism. The work presented here assesses the role of the signaling molecule protein kinase C theta (PKCθ) in the induction of IL-10 expression in CD4+ T cells. U
Externí odkaz:
https://doaj.org/article/fd3edca46cd7492d8a7fdd0143f3513d
Autor:
Graham J Britton, Rachel Ambler, Danielle J Clark, Elaine V Hill, Helen M Tunbridge, Kerrie E McNally, Bronwen R Burton, Philomena Butterweck, Catherine Sabatos-Peyton, Lea A Hampton-O’Neil, Paul Verkade, Christoph Wülfing, David Cameron Wraith
Publikováno v:
eLife, Vol 6 (2017)
Notch is a critical regulator of T cell differentiation and is activated through proteolytic cleavage in response to ligand engagement. Using murine myelin-reactive CD4 T cells, we demonstrate that proximal T cell signaling modulates Notch activation
Externí odkaz:
https://doaj.org/article/75afcfe3d41645f7a11ec23c03da7a47
Autor:
T.H. Sky eNg, Graham J Britton, Elaine V Hill, Johan eVerhagen, Bronwen R Burton, David C Wraith
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Since the discovery of interleukin-10 (IL-10) in the 1980s, a large body of work has led to its recognition as a pleiotropic immunomodulatory cytokine that affects both the innate and adaptive immune systems. IL-10 is produced by a wide range of cell
Externí odkaz:
https://doaj.org/article/5bd656703d4e4b859741d19bdb44821d
Autor:
Johan Verhagen, Bronwen R Burton, Graham J Britton, Ella R Shepard, Stephen M Anderton, David C Wraith
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61334 (2013)
T regulatory (Treg) cells expressing the transcription factor FoxP3 play a key role in protection against autoimmune disease. GFP-FoxP3 reporter mice have been used widely to study the induction, function and stability of both thymically- and periphe
Externí odkaz:
https://doaj.org/article/34b9ba27148f46459a568851af32d245
Autor:
Ella R. Shepard, Anja Wegner, Elaine V. Hill, Bronwen R. Burton, Sarah Aerts, Evelien Schurgers, Brecht Hoedemaekers, Sky T. H. Ng, Heather B. Streeter, Lotta Jansson, David C. Wraith
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Immunotherapy with antigen-processing independent T cell epitopes (apitopes) targeting autoreactive CD4+ T cells has translated to the clinic and been shown to modulate progression of both Graves’ disease and multiple sclerosis. The model apitope (
Externí odkaz:
https://doaj.org/article/7703b64009ca4397b26c63d3a5da8fce
Autor:
Brecht Hoedemaekers, Evelien Schurgers, Sarah Aerts, Heather B Streeter, Ella R. Shepard, Sky T. H. Ng, Anja Wegner, Lotta Jansson, Elaine V. Hill, Bronwen R Burton, David C. Wraith
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Immunotherapy with antigen-processing independent T cell epitopes (apitopes) targeting autoreactive CD4+ T cells has translated to the clinic and been shown to modulate progression of both Graves’ disease and multiple sclerosis. The model apitope (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b087e256a552b083bc6c9d528772a6d9
http://europepmc.org/articles/PMC8079784
http://europepmc.org/articles/PMC8079784
Autor:
Juliana Redondo, Harry R Haynes, Neil J Scolding, Alastair Wilkins, Mark A. Pook, Amelia J. Cook, Claire M Rice, Bronwen R Burton, Kevin C Kemp, Kelly M Hares
Publikováno v:
Annals of Neurology. 83:779-793
Objective Friedreich's ataxia is an incurable inherited neurological disease caused by frataxin deficiency. Here, we report the neuroreparative effects of myeloablative allogeneic bone marrow transplantation in a humanized murine model of the disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b356dde97f42dc1a4cb795c74596870
https://doi.org/10.1002/ana.25207
https://doi.org/10.1002/ana.25207
Autor:
Neil J Scolding, Richard Apps, Alastair Wilkins, Kelly M Hares, Nadia L Cerminara, Mark A. Pook, Juliana Redondo, Kevin C Kemp, Bronwen R Burton, Harry R Haynes, Amelia J. Cook
Publikováno v:
Annals of Neurology. 81:212-226
Objectives: Friedreich's ataxia is a devastating neurological disease currently lacking any proven treatment. We studied the neuro-protective effects of the cytokines granulocyte-colony stimulating factor and stem cell factor in a humanised murine mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2730d6ee2e25c50e7d35bb4e607c8aa2
https://doi.org/10.1002/ana.24846
https://doi.org/10.1002/ana.24846