Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Bronwen E Lambson"'
Autor:
Cathrine Scheepers, Prudence Kgagudi, Nonkululeko Mzindle, Elin S Gray, Thandeka Moyo-Gwete, Bronwen E Lambson, Brent Oosthuysen, Batsirai Mabvakure, Nigel J Garrett, Salim S Abdool Karim, Lynn Morris, Penny L Moore
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010450 (2022)
Broadly neutralizing antibodies (bNAbs) that target the membrane-proximal external region (MPER) of HIV gp41 envelope, such as 4E10, VRC42.01 and PGZL1, can neutralize >80% of viruses. These three MPER-directed monoclonal antibodies share germline an
Externí odkaz:
https://doaj.org/article/fbf5268d0dd44dbbb5f2f8afb6a19d60
Autor:
Simone I Richardson, Bronwen E Lambson, Andrew R Crowley, Arman Bashirova, Cathrine Scheepers, Nigel Garrett, Salim Abdool Karim, Nonhlanhla N Mkhize, Mary Carrington, Margaret E Ackerman, Penny L Moore, Lynn Morris
Publikováno v:
PLoS Pathogens, Vol 15, Iss 12, p e1008064 (2019)
Broadly neutralizing antibodies (bNAbs) protect against HIV infection in non-human primates and their efficacy may be enhanced through interaction with Fc receptors on immune cells. Antibody isotype is a modulator of this binding with the IgG3 subcla
Externí odkaz:
https://doaj.org/article/ef8d7295ee224b80a968bfae744f5b5a
Autor:
Penny L Moore, Nthabeleng Ranchobe, Bronwen E Lambson, Elin S Gray, Eleanor Cave, Melissa-Rose Abrahams, Gama Bandawe, Koleka Mlisana, Salim S Abdool Karim, Carolyn Williamson, Lynn Morris, CAPRISA 002 Study, NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
Publikováno v:
PLoS Pathogens, Vol 5, Iss 9, p e1000598 (2009)
We previously showed that HIV-1 subtype C viruses elicit potent but highly type-specific neutralizing antibodies (nAb) within the first year of infection. In order to determine the specificity and evolution of these autologous nAbs, we examined neutr
Externí odkaz:
https://doaj.org/article/962b8d8e6e974043946d37232f884055
Autor:
Jinal N. Bhiman, Simone I. Richardson, Bronwen E. Lambson, Prudence Kgagudi, Nonkululeko Mzindle, Haajira Kaldine, Carol Crowther, Glenda Gray, Linda-Gail Bekker, Novavax trial clinical lead author group, Vivek Shinde, Chijioke Bennett, Gregory M. Glenn, Shabir A. Madhi, Penny L. Moore
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-5 (2023)
Abstract The SARS-CoV-2 Omicron (B.1.1.529) Variant of Concern (VOC) and its sub-lineages (including BA.2, BA.4, BA.5, BA.2.12.1) contain spike mutations that confer high level resistance to neutralizing antibodies induced by vaccination with ancestr
Externí odkaz:
https://doaj.org/article/6e50f56803a24a00a13ebf541e441d6d
Autor:
Thandeka Moyo-Gwete, Cathrine Scheepers, Zanele Makhado, Prudence Kgagudi, Nonkululeko B. Mzindle, Rutendo Ziki, Sharon Madzorera, Nelia P. Manamela, Frances Ayres, Bronwen E. Lambson, Simone I. Richardson, Lynn Morris, Penny L. Moore
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Antibodies with the same variable region can exist as multiple isotypes with varying neutralization potencies, though the mechanism for this is not fully defined. We previously isolated an HIV-directed IgA1 monoclonal antibody (mAb), CAP88-C
Externí odkaz:
https://doaj.org/article/c2c5fc6c15e34f56b2798fa353ccefee
Autor:
Cathrine Scheepers, Josie Everatt, Daniel G. Amoako, Houriiyah Tegally, Constantinos Kurt Wibmer, Anele Mnguni, Arshad Ismail, Boitshoko Mahlangu, Bronwen E. Lambson, Darren P. Martin, Eduan Wilkinson, James Emmanuel San, Jennifer Giandhari, Nelia Manamela, Noxolo Ntuli, Prudence Kgagudi, Sandile Cele, Simone I. Richardson, Sureshnee Pillay, Thabo Mohale, Upasana Ramphal, Yeshnee Naidoo, Zamantungwa T. Khumalo, Gaurav Kwatra, Glenda Gray, Linda-Gail Bekker, Shabir A. Madhi, Vicky Baillie, Wesley C. Van Voorhis, Florette K. Treurnicht, Marietjie Venter, Koleka Mlisana, Nicole Wolter, Alex Sigal, Carolyn Williamson, Nei-yuan Hsiao, Nokukhanya Msomi, Tongai Maponga, Wolfgang Preiser, Zinhle Makatini, Richard Lessells, Penny L. Moore, Tulio de Oliveira, Anne von Gottberg, Jinal N. Bhiman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The SARS-CoV-2 PANGO lineage C.1.2 has been under monitoring by global health authorities as it has spread worldwide. Here, Bhiman and colleagues characterise the emergence of the lineage, and its neutralisation sensitivity using data from vaccinees
Externí odkaz:
https://doaj.org/article/e365317a28774fd29c4b6a0f6a77a17a
Autor:
Jinal N. Bhiman, Simone I. Richardson, Bronwen E. Lambson, Prudence Kgagudi, Nonkululeko Mzindle, Haajira Kaldine, Carol Crowther, Glenda Gray, Linda-Gail Bekker, Vivek Shinde, Chijioke Bennett, Gregory M. Glenn, Shabir Madhi, Penny L. Moore, Anthonet Koen, Lee Fairlie, Leon Fouche, Qasim Bhorat, Keertan Dheda, Michele Tameris, Mduduzi Masilela, Zaheer Hoosain, Nishanta Singh, Sherika Hanley, Moherndran Archary, Cheryl Louw, Coert Grobbelaar, Umesh Lalloo, Natasha Joseph, Gertruida Kruger
The SARS-CoV-2 Omicron (B.1.1.529) Variant of Concern (VOC) and its sub-lineages (including BA.2, BA.4, BA.5, BA.2.12.1) contain spike mutations that confer high level resistance to neutralizing antibodies. The NVX-CoV2373 vaccine, a protein nanopart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f20617718c04f1389485913a5c0f8788
https://doi.org/10.21203/rs.3.rs-2048259/v1
https://doi.org/10.21203/rs.3.rs-2048259/v1
Autor:
Genevieve Mezoh, Nereshni Lutchman, Eleanor M Cave, Katherine Prigge, Catherine Worsley, Neil Martinson, Elizabeth Mayne, Bronwen E Lambson, Penny L Moore, Nigel J Crowther
Infection with HIV is associated with an increased risk of cardiovascular disease (CVD), which may be mediated by the effect of the viral proteins, Nef and Tat, on inflammation and endothelial activation. The viral genes coding for Nef and Tat contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf3ba773fcf2958d6dfe245e63ca4703
https://doi.org/10.1101/2022.10.10.511468
https://doi.org/10.1101/2022.10.10.511468
Autor:
Thandeka Moyo-Gwete, Mashudu Madzivhandila, Nonhlanhla N Mkhize, Prudence Kgagudi, Frances Ayres, Bronwen E Lambson, Nelia P Manamela, Simone I Richardson, Zanele Makhado, Mieke A van der Mescht, Zelda de Beer, Talita Roma de Villiers, Wendy A Burgers, Ntobeko A B Ntusi, Theresa Rossouw, Veronica Ueckermann, Michael T Boswell, Penny L Moore
Publikováno v:
Journal of Virology. 96
As SARS-CoV-2 continues to evolve, several variants of concern (VOCs) have arisen which are defined by multiple mutations in their spike proteins. These VOCs have shown variable escape from antibody responses, and have been shown to trigger qualitati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed5186ecfd03a0afb63e84b7a59f84c
https://doi.org/10.1128/jvi.00558-22
https://doi.org/10.1128/jvi.00558-22
Autor:
Simone I. Richardson, Thopisang Motlou, Mieke A. van der Mescht, Bronwen E. Lambson, Josie Everatt, Daniel Gyamfi Amoako, Anne von Gottberg, Nicole Wolter, Zelda de Beer, Talita Roma de Villiers, Annie Bodenstein, Gretha van den Berg, Theresa M. Rossouw, Michael T. Boswell, Veronica Ueckermann, Jinal N. Bhiman, Penny L. Moore
SARS-CoV-2 variants of concern (VOCs) differentially trigger neutralizing antibodies with variable cross-neutralizing capacity. Here we show that unlike SARS-CoV-2 Omicron BA.1, which triggered neutralizing antibodies with limited cross-reactivity, B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::674e29a39a86baa8fe9ffa7f6903a1ea
https://doi.org/10.1101/2022.07.14.500039
https://doi.org/10.1101/2022.07.14.500039