Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Bronson A. Haynes"'
Autor:
Anca D. Dobrian, Kaiwen Ma, Lindsey M. Glenn, Margaret A. Hatcher, Bronson A. Haynes, Eric J. Lehrer, Mark H. Kaplan, Jerry L. Nadler
Publikováno v:
Mediators of Inflammation, Vol 2017 (2017)
Visceral adipose tissue (AT) inflammation is linked to the complications of obesity, including insulin resistance (IR) and type 2 diabetes. Recent data from our lab showed that germline deficiency in STAT4 reduces inflammation and improves IR in obes
Externí odkaz:
https://doaj.org/article/9ceffdc394524b3096a1d1b25688cd84
Autor:
Julia A. Sharp, Allison M. Rusk, Jessica A. Burket, Bronson A. Haynes, Jerrah C. Pickle, Stephen I. Deutsch
Publikováno v:
Progress in neuro-psychopharmacologybiological psychiatry. 99
Stress reactivity and glucocorticoid signaling alterations are reported in mouse models of autism spectrum disorder (ASD). BALB/c mice display decreased locomotor activity in the presence of stimulus mice and spend less time exploring enclosed stimul
Autor:
Vijay Gottipati, Anna Marley, William L. McPheat, Bronson A. Haynes, Lindsey Glenn, Jerry L. Nadler, Göran I. Hansson, Ryan W. Huyck, Anca D. Dobrian
Publikováno v:
Prostaglandins & Other Lipid Mediators. 136:23-32
The 12-lipoxygenase (12LO) pathway is a promising target to reduce islet dysfunction, adipose tissue (AT) inflammation and insulin resistance. Optimal pre-clinical models for the investigation of selective12LO inhibitors in this context have not yet
Autor:
Joshua M. Turner, Vanessa L. Correll, Allison Mathiesen, Nektarios Barabutis, Eric J. Lehrer, Ryan W. Huyck, Anca D. Dobrian, Li Fang Yang, O. John Semmes, Bronson A. Haynes, William McPheat
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Endothelial cells (EC) in obese adipose tissue (AT) are exposed to a chronic proinflammatory environment that may induce a mesenchymal-like phenotype and altered function. The objective of this study was to establish whether endothelial-to
Autor:
P Taghavie-Moghadam, Elena V. Galkina, Jerry L. Nadler, Anca D. Dobrian, Joshua J. Brotman, Bronson A. Haynes, Margaret A Hatcher, H Pei
Publikováno v:
Journal of Endocrinology. 227:13-24
Adipose tissue (AT) inflammation is an emerging factor contributing to cardiovascular disease. STAT4 is a transcription factor expressed in adipocytes and in immune cells and contributes to AT inflammation and insulin resistance in obesity. The objec
Autor:
Ryan W. Huyck, Avennette Pinto, Ashley J James, Omnia U Gaafar, Bronson A. Haynes, Anca D. Dobrian, Meghan E Carter, Marjorie Day
Publikováno v:
Journal of Visualized Experiments.
Obesity is accompanied by an extensive remodeling of adipose tissue primarily via adipocyte hypertrophy. Extreme adipocyte growth results in a poor response to insulin, local hypoxia, and inflammation. By stimulating the differentiation of functional
Autor:
Jessica A. Burket, Allison M. Rusk, Bronson A. Haynes, Julia A. Sharp, Jerrah C. Pickle, Stephen I. Deutsch
Publikováno v:
Biological Psychiatry. 85:S323-S324
Autor:
Kaiwen Ma, Anca D. Dobrian, Bronson A. Haynes, Lindsey Glenn, Jerry L. Nadler, Mark H. Kaplan, Eric J. Lehrer, Margaret A Hatcher
Publikováno v:
Mediators of Inflammation, Vol 2017 (2017)
Mediators of Inflammation
Mediators of Inflammation
Visceral adipose tissue (AT) inflammation is linked to the complications of obesity, including insulin resistance (IR) and type 2 diabetes. Recent data from our lab showed that germline deficiency in STAT4 reduces inflammation and improves IR in obes
Autor:
Jerry L. Nadler, Sabai Myo Aye, Margaret A Hatcher, Kaiwen Ma, Mark H. Kaplan, Mathew J. Butcher, Elena V. Galkina, Anca D. Dobrian, Bronson A. Haynes, Qian Ma
Publikováno v:
Diabetes
Signal transducer and activator of transcription (STAT) 4 is one of the seven members of the STAT family. STAT4 has a prominent role in mediating interleukin-12–induced T-helper cell type 1 lineage differentiation. T cells are key players in the ma
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36
In obesity, excess lipid storage and reduced adipogenesis causes adipocytes to undergo hypertrophy leading to inflammation and insulin resistance. Increasing adipogenic potential may reduce lipid overload and ectopic lipid accumulation. In mice, the