Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

Autor: Bos, R.M. van den, Pearce, N.M., Granneman, J., Brondijk, T.H.C., Gros, P., Berger, S., Born, J. van den, Heuvel, L. van den, Kar, N. van de, Kooten, C. van, Seelen, M., Vries, A. de, COMBAT Consortium

Publikováno v: Frontiers in Immunology
'Frontiers in Immunology ', vol: 10, pages: 2097-1-2097-19 (2019)
Frontiers in Immunology, 10:2097. Frontiers Media SA
Frontiers in Immunology, 10
Frontiers in Immunology, 10. FRONTIERS MEDIA SA
Frontiers in Immunology, Vol 10 (2019)

Properdin enhances complement-mediated opsonization of targeted cells and particles for immune clearance. Properdin occurs as dimers, trimers and tetramers in human plasma, which recognize C3b-deposited surfaces, promote formation, and prolong the li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9659ae939fdcb54fe9dc128d2fdbf07
https://doi.org/10.3389/fimmu.2019.02097

Implications for collagen I chain registry from the structure of the collagen von Willebrand factor A3 domain complex

Autor: Brondijk, T.H.C., Bihan, D., Farndale, R.W., Huizinga, E.G., Crystal and Structural Chemistry, Rontgen participation programme, Sub Crystal and Structural Chemistry

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 109(14), 5353. National Academy of Sciences

Fibrillar collagens, the most abundant proteins in the vertebrate body, are involved in a plethora of biological interactions. Plasma protein von Willebrand factor (VWF) mediates adhesion of blood platelets to fibrillar collagen types I, II, and III,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab70cc7b66421490bc3f6a1949d6924
https://pubmed.ncbi.nlm.nih.gov/22440751

Crystal structures of TAFI elucidate the inactivation mechanism of activated TAFI: a novel mechanism for enzyme autoregulation

Autor: Marx, P.F., Brondijk, T.H.C., Plug, T., Romijn, R.A., Hemrika, W., Meijers, J.C.M., Huizinga, E.G.

Thrombin-activatable fibrinolysis inhibitor (TAFI) is a pro-metallocarboxypeptidase that can be proteolytically activated (TAFIa). TAFIa is unique among carboxypeptidases in that it spontaneously inactivates with a short half-life, a property that is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______101::b3e5ec77c04eab3f934f16395bb8c047
https://dspace.library.uu.nl/handle/1874/32221

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