Výsledky vyhledávání - "Bronchial epithelium"

Akademický článek

Single-cell RNA sequencing reveals heterogeneity of ALI model and epithelial cell alterations after exposure to electronic cigarette aerosol

Autor: Meng-yun Cai, Xiaofan Mao, Beiying Zhang, Chung-Yin Yip, Ke-wu Pan, Ya Niu, Stephen Kwok-Wing Tsui, Joaquim Si-Long Vong, Judith Choi-Wo Mak, Wei Luo, Wing-Hung Ko

Publikováno v: Heliyon, Vol 10, Iss 19, Pp e38552- (2024)

Electronic cigarettes (e-cigarettes) have been advertised as a healthier alternative to traditional cigarettes; however, their exact effects on the bronchial epithelium are poorly understood. Air-liquid interface culture human bronchial epithelium (A

Externí odkaz: https://doaj.org/article/9c6b19d76a624685bf5393b01e151d30

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Akademický článek

Septin-dependent defense mechanisms against Pseudomonas aeruginosa are stalled in cystic fibrosis bronchial epithelial cells

Autor: Sylvain Brax, Clémence Gaudin, Claire Calmel, Pierre-Yves Boëlle, Harriet Corvol, Manon Ruffin, Loïc Guillot

Publikováno v: European Journal of Cell Biology, Vol 103, Iss 2, Pp 151416- (2024)

Airway epithelial cells form a physical barrier against inhaled pathogens and coordinate innate immune responses in the lungs. Bronchial cells in people with cystic fibrosis (pwCF) are colonized by Pseudomonas aeruginosa because of the accumulation o

Externí odkaz: https://doaj.org/article/b9a1e1a68a9840f3bb7fa460862a7b68

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Akademický článek

Olfactory receptors impact pathophysiological processes of lung diseases in bronchial epithelial cells

Autor: Daniel Weidinger, Julian Jacobsen, Desiree Alisch, Hendrik Uebner, Natalie Heinen, Lea Greune, Saskia Westhoven, Kaschin Jamal Jameel, Juliane Kronsbein, Stephanie Pfaender, Christian Taube, Sebastian Reuter, Marcus Peters, Hanns Hatt, Jürgen Knobloch

Publikováno v: European Journal of Cell Biology, Vol 103, Iss 2, Pp 151408- (2024)

Background: Therapeutic options for steroid-resistant non-type 2 inflammation in obstructive lung diseases are limited. Bronchial epithelial cells are key in the pathogenesis by releasing the central proinflammatory cytokine interleukine-8 (IL-8). Ol

Externí odkaz: https://doaj.org/article/8c40ec58da63480da34a07462736bc89

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Akademický článek

Acute cigarette smoke exposure leads to higher viral infection in human bronchial epithelial cultures by altering interferon, glycolysis and GDF15-related pathways

Autor: Ying Wang, Dennis K. Ninaber, Alen Faiz, Abraham C. van der Linden, Annemarie van Schadewijk, René Lutter, Pieter S. Hiemstra, Anne M. van der Does, Abilash Ravi

Publikováno v: Respiratory Research, Vol 24, Iss 1, Pp 1-16 (2023)

Abstract Background Acute exacerbations of chronic inflammatory lung diseases, such as chronic obstructive pulmonary disease (COPD), are frequently associated with rhinovirus (RV) infections. Despite these associations, the pathogenesis of virus-indu

Externí odkaz: https://doaj.org/article/0f718170c5814a07a68d573420f11365

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Akademický článek

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The Novel Inducer of Innate Immunity HO53 Stimulates Autophagy in Human Airway Epithelial Cells

Autor: Iwona T. Myszor, Snaevar Sigurdsson, Alexia Ros Viktorsdottir, Birgitta Agerberth, Eeva-Liisa Eskelinen, Margret Helga Ogmundsdottir, Gudmundur H. Gudmundsson

Publikováno v: Journal of Innate Immunity, Pp 1-16 (2022)

Aroylated phenylenediamines (APDs) are novel modulators of innate immunity with respect to enhancing the expression of antimicrobial peptides and maintaining epithelial barrier integrity. Here, we present a new study on induction of autophagy in huma

Externí odkaz: https://doaj.org/article/9b0312b339784470bde7471b75cf1e7d

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Akademický článek

Human milk extracellular vesicles preserve bronchial epithelial barrier integrity and reduce TLR3‐induced inflammation in vitro

Autor: Nikita Karra, Martijn J. C. Van Herwijnen, Marca H. M. Wauben, Emily Jane Swindle, Hywel Morgan

Publikováno v: Journal of Extracellular Biology, Vol 1, Iss 9, Pp n/a-n/a (2022)

Abstract Breast milk is essential for facilitating the growth and development of infants and for providing immune protection against viral infections in the infant's airways. Yet, regulation of inflammation by milk components may be needed to reduce

Externí odkaz: https://doaj.org/article/c6ecc34500054c1ba0e7c25223d9f866

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Akademický článek

Bronchus-associated macrophages efficiently capture and present soluble inhaled antigens and are capable of local Th2 cell activation

Autor: Xin-Zi Tang, Lieselotte S M Kreuk, Cynthia Cho, Ross J Metzger, Christopher D C Allen

Publikováno v: eLife, Vol 11 (2022)

In allergic asthma, allergen inhalation leads to local Th2 cell activation and peribronchial inflammation. However, the mechanisms for local antigen capture and presentation remain unclear. By two-photon microscopy of the mouse lung, we established t

Externí odkaz: https://doaj.org/article/c701738a0a0744a488f8ec55442ad8e0

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