Inflammation impacts androgen receptor signaling in basal prostate stem cells through interleukin 1 receptor antagonist.

Autor: Cooper PO; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.; Purdue Institute for Cancer Research, West Lafayette, IN, USA.; Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA., Yang J; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA. yang1491@purdue.edu.; Purdue Institute for Cancer Research, West Lafayette, IN, USA. yang1491@purdue.edu., Wang HH; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.; Purdue Institute for Cancer Research, West Lafayette, IN, USA.; Immune Monitoring and Genomics Facility, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Broman MM; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.; Purdue Institute for Cancer Research, West Lafayette, IN, USA., Jayasundara SM; Department of Computer Science, Purdue University, West Lafayette, IN, USA., Sahoo SS; Department of Biochemistry, Purdue University, West Lafayette, IN, USA., Yan B; Department of Biochemistry, Purdue University, West Lafayette, IN, USA., Awdalkreem GD; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.; Purdue Institute for Cancer Research, West Lafayette, IN, USA., Cresswell GM; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.; Purdue Institute for Cancer Research, West Lafayette, IN, USA.; Flow Cytometry Core Facility, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA., Wang L; Department of Pharmacology and Toxicology, Department of Urology, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA., Goossens E; Department of Statistics, Purdue University, West Lafayette, IN, USA., Lanman NA; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.; Purdue Institute for Cancer Research, West Lafayette, IN, USA., Doerge RW; Department of Statistics, Purdue University, West Lafayette, IN, USA.; Rensselaer Polytechnic Institute, Troy, NY, USA., Zheng F; Department of Statistics, Purdue University, West Lafayette, IN, USA.; Sorcero, Inc., Washington, DC, USA., Cheng L; Department of Pathology and Laboratory Medicine, Department of Surgery (Urology), Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, RI, USA., Alqahtani S; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.; Purdue Institute for Cancer Research, West Lafayette, IN, USA., Crist SA; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.; Purdue Institute for Cancer Research, West Lafayette, IN, USA.; Carver College of Medicine, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA., Braun RE; The Jackson Laboratory, Bar Harbor, ME, USA., Kazemian M; Purdue Institute for Cancer Research, West Lafayette, IN, USA.; Department of Computer Science, Purdue University, West Lafayette, IN, USA.; Department of Biochemistry, Purdue University, West Lafayette, IN, USA., Jerde TJ; Department of Pharmacology and Toxicology, Department of Urology, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA. tjjerde@iu.edu., Ratliff TL; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA. tlratliff@purdue.edu.; Purdue Institute for Cancer Research, West Lafayette, IN, USA. tlratliff@purdue.edu.

Publikováno v: Communications biology [Commun Biol] 2024 Oct 25; Vol. 7 (1), pp. 1390. Date of Electronic Publication: 2024 Oct 25.

Inflammation Impacts Androgen Receptor Signaling in Basal Prostate Stem Cells Through Interleukin 1 Receptor Antagonist.

Autor: Cooper PO; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Cancer Research, West Lafayette, IN 47907, USA.; These authors contributed equally to the manuscript., Yang J; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Cancer Research, West Lafayette, IN 47907, USA.; These authors contributed equally to the manuscript., Wang HH; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Cancer Research, West Lafayette, IN 47907, USA.; These authors contributed equally to the manuscript., Broman MM; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Cancer Research, West Lafayette, IN 47907, USA., Awdalkreem GD; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Cancer Research, West Lafayette, IN 47907, USA., Cresswell GM; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Cancer Research, West Lafayette, IN 47907, USA., Wang L; Department of Pharmacology and Toxicology, Department of Urology, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Goossens E; Department of Statistics, Purdue University, West Lafayette, IN 47907, USA., Lanman NA; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Cancer Research, West Lafayette, IN 47907, USA., Doerge RW; Department of Statistics, Purdue University, West Lafayette, IN 47907, USA., Zheng F; Department of Statistics, Purdue University, West Lafayette, IN 47907, USA., Cheng L; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Crist SA; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Cancer Research, West Lafayette, IN 47907, USA., Braun RE; The Jackson Laboratory, Bar Harbor, ME 04609, USA., Jerde TJ; Department of Pharmacology and Toxicology, Department of Urology, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Ratliff TL; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Cancer Research, West Lafayette, IN 47907, USA.

Publikováno v: Research square [Res Sq] 2023 Dec 15. Date of Electronic Publication: 2023 Dec 15.

TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease.

Autor: Vickman RE; Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine, Evanston, IL, 60201, USA., Aaron-Brooks L; Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine, Evanston, IL, 60201, USA.; Department of Cancer Biology, Meharry Medical College, Nashville, TN, 37208, USA., Zhang R; Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA., Lanman NA; Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, 47907, USA.; Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, 47907, USA., Lapin B; Biostatistics and Research Informatics, NorthShore University HealthSystem, Evanston, IL, 60201, USA.; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA., Gil V; Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine, Evanston, IL, 60201, USA., Greenberg M; Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine, Evanston, IL, 60201, USA., Sasaki T; Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine, Evanston, IL, 60201, USA.; Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Mie, Japan., Cresswell GM; Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, 47907, USA.; GW Cancer Center, The George Washington University, Washington, DC, 20052, USA., Broman MM; Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, 47907, USA., Paez JS; Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, 47907, USA.; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA., Petkewicz J; Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine, Evanston, IL, 60201, USA., Talaty P; Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine, Evanston, IL, 60201, USA., Helfand BT; Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine, Evanston, IL, 60201, USA., Glaser AP; Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine, Evanston, IL, 60201, USA., Wang CH; Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine, Evanston, IL, 60201, USA.; Biostatistics and Research Informatics, NorthShore University HealthSystem, Evanston, IL, 60201, USA., Franco OE; Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine, Evanston, IL, 60201, USA., Ratliff TL; Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, 47907, USA.; Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, 47907, USA., Nastiuk KL; Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.; Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA., Crawford SE; Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine, Evanston, IL, 60201, USA., Hayward SW; Department of Surgery, NorthShore University HealthSystem, an Academic Affiliate of the University of Chicago Pritzker School of Medicine, Evanston, IL, 60201, USA. shayward@northshore.org.

Publikováno v: Nature communications [Nat Commun] 2022 Apr 19; Vol. 13 (1), pp. 2133. Date of Electronic Publication: 2022 Apr 19.

Heterogeneity of human prostate carcinoma-associated fibroblasts implicates a role for subpopulations in myeloid cell recruitment.

Autor: Vickman RE; Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois., Broman MM; Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana., Lanman NA; Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana.; Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana., Franco OE; Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois., Sudyanti PAG; Department of Statistics, Purdue University, West Lafayette, Indiana., Ni Y; Department of Statistics, Texas A&M University, College Station, Texas., Ji Y; Department of Public Health Sciences, University of Chicago, Chicago, Illinois., Helfand BT; Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois., Petkewicz J; Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois., Paterakos MC; Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois., Crawford SE; Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois., Ratliff TL; Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana.; Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana., Hayward SW; Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois.

Publikováno v: The Prostate [Prostate] 2020 Feb; Vol. 80 (2), pp. 173-185. Date of Electronic Publication: 2019 Nov 25.

Identification of LIMK2 as a therapeutic target in castration resistant prostate cancer.

Autor: Nikhil K; Department of Chemistry and Purdue University Center for Cancer Research, 560 Oval Drive, West Lafayette, IN, 47907, USA., Chang L; Department of Chemistry and Purdue University Center for Cancer Research, 560 Oval Drive, West Lafayette, IN, 47907, USA., Viccaro K; Department of Chemistry and Purdue University Center for Cancer Research, 560 Oval Drive, West Lafayette, IN, 47907, USA., Jacobsen M; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Drive, Room A-128, Indianapolis, IN, 46202, USA., McGuire C; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Drive, Room A-128, Indianapolis, IN, 46202, USA., Satapathy SR; Department of Chemistry and Purdue University Center for Cancer Research, 560 Oval Drive, West Lafayette, IN, 47907, USA., Tandiary M; Department of Chemistry and Purdue University Center for Cancer Research, 560 Oval Drive, West Lafayette, IN, 47907, USA., Broman MM; Department of Comparative Pathobiology and Purdue University Center for Cancer Research, 625 Harrison Street, West Lafayette, IN, 47907, USA., Cresswell G; Department of Comparative Pathobiology and Purdue University Center for Cancer Research, 625 Harrison Street, West Lafayette, IN, 47907, USA., He YJ; Dana Farber Cancer Institute, Harvard Institute of Medicine, Room HIM-229, 4 Blackfan Cir, Boston, MA, 02215, USA., Sandusky GE; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Drive, Room A-128, Indianapolis, IN, 46202, USA., Ratliff TL; Department of Comparative Pathobiology and Purdue University Center for Cancer Research, 625 Harrison Street, West Lafayette, IN, 47907, USA., Chowdhury D; Dana Farber Cancer Institute, Harvard Institute of Medicine, Room HIM-229, 4 Blackfan Cir, Boston, MA, 02215, USA., Shah K; Department of Chemistry and Purdue University Center for Cancer Research, 560 Oval Drive, West Lafayette, IN, 47907, USA. Electronic address: shah23@purdue.edu.

Publikováno v: Cancer letters [Cancer Lett] 2019 Apr 28; Vol. 448, pp. 182-196. Date of Electronic Publication: 2019 Feb 01.