Understanding the role of RNA nucleases in human disease

Autor: Brolih, S

Congenital dyserythropoietic anaemia type-I (CDA-I) is a rare inherited disorder of erythropoiesis, in which patient erythroblasts uniquely display a pathognomonic pattern of heterochromatin, referred to as ‘spongy’ heterochromatin. The molecular

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https://ora.ox.ac.uk/objects/uuid:0911808e-063e-4b99-818e-83e15be6f8d0

RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks

Autor: Abdullah, UB, McGouran, JF, Brolih, S, Ptchelkine, D, El-Sagheer, AH, Brown, T, McHugh, PJ

Publikováno v: EMBO Journal
EMBO Journal, 2017, 36, pp.2047-2060. ⟨10.15252/embj.201796664⟩

During replication-coupled DNA interstrand crosslink (ICL) repair, the XPF-ERCC1 endonuclease is required for the incisions that release, or "unhook", ICLs, but the mechanism of ICL unhooking remains largely unknown. Incisions are triggered when the

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https://ora.ox.ac.uk/objects/uuid:65133b95-7b96-4fe0-9b26-5e000080fb19

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RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks.

Autor: Abdullah UB; Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., McGouran JF; Department of Chemistry, University of Oxford, Oxford, UK., Brolih S; Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Ptchelkine D; Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Research Complex at Harwell, Rutherford Appleton Laboratory, Oxford, UK., El-Sagheer AH; Department of Chemistry, University of Oxford, Oxford, UK., Brown T; Department of Chemistry, University of Oxford, Oxford, UK.; Department of Oncology, University of Oxford, Oxford, UK., McHugh PJ; Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK peter.mchugh@imm.ox.ac.uk.

Publikováno v: The EMBO journal [EMBO J] 2017 Jul 14; Vol. 36 (14), pp. 2047-2060. Date of Electronic Publication: 2017 Jun 12.