Combined sialic acid and histone deacetylase (HDAC) inhibitor treatment up-regulates the neuroblastoma antigen GD2.

Autor: van den Bijgaart RJE; From the Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Kroesen M; the Department of Radiotherapy, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands., Wassink M; From the Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Brok IC; From the Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Kers-Rebel ED; From the Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Boon L; Bioceros, 3584 CM Utrecht, The Netherlands., Heise T; the Cluster for Molecular Chemistry, Institute for Molecules and Materials, Radboud University, 6525 AJ Nijmegen, The Netherlands., van Scherpenzeel M; the Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Medical Center, 6525 DA Nijmegen, the Netherlands, and., Lefeber DJ; the Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Medical Center, 6525 DA Nijmegen, the Netherlands, and., Boltje TJ; the Cluster for Molecular Chemistry, Institute for Molecules and Materials, Radboud University, 6525 AJ Nijmegen, The Netherlands., den Brok MH; From the Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Hoogerbrugge PM; the Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands., Büll C; From the Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Adema GJ; From the Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands, gosse.adema@radboudumc.nl.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2019 Mar 22; Vol. 294 (12), pp. 4437-4449. Date of Electronic Publication: 2019 Jan 22.

Intra-adrenal murine TH-MYCN neuroblastoma tumors grow more aggressive and exhibit a distinct tumor microenvironment relative to their subcutaneous equivalents.

Autor: Kroesen M; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences/278 TIL, Radboud University Medical Center, Post Box 9101, 6500 HB, Nijmegen, The Netherlands., Brok IC, Reijnen D, van Hout-Kuijer MA, Zeelenberg IS, Den Brok MH, Hoogerbrugge PM, Adema GJ

Publikováno v: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2015 May; Vol. 64 (5), pp. 563-72. Date of Electronic Publication: 2015 Feb 17.