Treatment of hepatitis C monoinfection in adults - Dutch national guidelines

Autor: Lamers, H, Broekman, MMTJ, Boucher, Charles, Brouwer, JT, Burger, DM, van Hoek, B, Hoepelman, AIM, de Knegt, Rob, Reesink, HW, Drenth, JPH

Publikováno v: Netherlands Journal of Medicine, 71(7), 377-385. Van Zuiden Communications

In this new Dutch guideline for hepatitis C virus infection we provide recommendations for the management of hepatitis C infection. Until 2012 the standard for treatment consisted of pegylated interferon alpha (peg-IFN alpha) and ribavirin. The adven

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https://pure.eur.nl/en/publications/df09366e-4b2c-4f63-95ca-ee4bc76eec77

Patients' beliefs about medicine are associated with early thiopurine discontinuation in patients with inflammatory bowel diseases.

Autor: Broekman MMTJ; Department of Gastroenterology, Radboud Institute for Molecular Life Sciences., Coenen MJH; Departments of Human Genetics., Wanten GJ; Department of Gastroenterology, Radboud Institute for Molecular Life Sciences., van Marrewijk CJ; Departments of Human Genetics., Kievit W; Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen., Klungel OH; Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht., Verbeek ALM; Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen., Wong DR; Department of Clinical Pharmacy, Pharmacology and Toxicology, Zuyderland Medical Center, Sittard-Geleen., Hooymans PM; Department of Clinical Pharmacy, Pharmacology and Toxicology, Zuyderland Medical Center, Sittard-Geleen., Guchelaar HJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center., Scheffer H; Departments of Human Genetics., Derijks LJJ; Department of Clinical Pharmacy, Máxima Medical Center, Veldhoven, The Netherlands., Bouvy ML; Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht.; SIR institute for Pharmacy Practice and Policy, Leiden., de Jong DJ; Department of Gastroenterology, Radboud Institute for Molecular Life Sciences.

Publikováno v: European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2018 Feb; Vol. 30 (2), pp. 167-173.

The glutathione transferase Mu null genotype leads to lower 6-MMPR levels in patients treated with azathioprine but not with mercaptopurine.

Autor: Broekman MMTJ; Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Gastroenterology, Nijmegen, The Netherlands., Wong DR; Department of Clinical Pharmacy, Pharmacology and Toxicology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands., Wanten GJA; Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Gastroenterology, Nijmegen, The Netherlands., Roelofs HM; Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Gastroenterology, Nijmegen, The Netherlands., van Marrewijk CJ; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Human Genetics, Nijmegen, The Netherlands., Klungel OH; Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, The Netherlands., Verbeek ALM; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Hooymans PM; Department of Clinical Pharmacy, Pharmacology and Toxicology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands., Guchelaar HJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Scheffer H; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Human Genetics, Nijmegen, The Netherlands., Derijks LJJ; Department of Clinical Pharmacy, Máxima Medical Center, Veldhoven, The Netherlands., Coenen MJH; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Human Genetics, Nijmegen, The Netherlands., de Jong DJ; Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Gastroenterology, Nijmegen, The Netherlands.

Publikováno v: The pharmacogenomics journal [Pharmacogenomics J] 2018 Jan; Vol. 18 (1), pp. 160-166. Date of Electronic Publication: 2017 Jan 03.

More Dose-dependent Side Effects with Mercaptopurine over Azathioprine in IBD Treatment Due to Relatively Higher Dosing.

Autor: Broekman MMTJ; Departments of *Gastroenterology, †Human Genetics, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands; ‡Department of Clinical Pharmacy, Pharmacology and Toxicology, Zuyderland Medical Center, Sittard-Geleen, the Netherlands; §Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands; ‖Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, the Netherlands; ¶Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands; and **Department of Clinical Pharmacy, Máxima Medical Center, Veldhoven, the Netherlands., Coenen MJH, van Marrewijk CJ, Wanten GJA, Wong DR, Verbeek ALM, Klungel OH, Hooymans PM, Guchelaar HJ, Scheffer H, Derijks LJJ, de Jong DJ

Publikováno v: Inflammatory bowel diseases [Inflamm Bowel Dis] 2017 Oct; Vol. 23 (10), pp. 1873-1881.