Biokinetics of chlorpromazine in primary rat and human hepatocytes and human HepaRG cells after repeated exposure

Autor: Broeders, Jessica J W, Parmentier, Céline, Truisi, Germaine L, Jossé, Rozenn, Alexandre, Eliane, Savary, Camille C, Hewitt, Philip G, Mueller, Stefan O, Guillouzo, André, Richert, Lysiane, van Eijkeren, Jan C H, Hermens, Joop L M, Blaauboer, Bas J, Risk Assessment of Toxic and Immunomodulatory Agents, LS IRAS Tox CMT/ATX, Sub IRAS Tox MTX Milieutoxicologie), IRAS RATIA1

Publikováno v: Toxicology in Vitro, 30(1 Pt A), 52. NLM (Medline)
Toxicology in Vitro
Toxicology in Vitro, Elsevier, 2015, 30 (1), pp.52-61. ⟨10.1016/j.tiv.2014.08.012⟩
Toxicology in Vitro, 2015, 30 (1), pp.52-61. ⟨10.1016/j.tiv.2014.08.012⟩

International audience; Since drug induced liver injury is difficult to predict in animal models, more representative tests are needed to better evaluate these effects in humans. Existing in vitro systems hold great potential to detect hepatotoxicity

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https://dspace.library.uu.nl/handle/1874/329931

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Biokinetics of chlorpromazine in primary rat and human hepatocytes and human HepaRG cells after repeated exposure.

Autor: Broeders JJ; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. Electronic address: jessica.broeders@ctgb.nl., Parmentier C; Kaly-Cell, 20A Rue du Général Leclerc, Plobsheim, France., Truisi GL; Non-Clinical Safety, Merck Serono, Merck KGaA, Darmstadt, Germany; Institut für Angewandte Biowissenschaften, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany., Jossé R; Institut National de la Santé et de la Recherche Médicale U991, Université de Rennes 1, Rennes, France., Alexandre E; Kaly-Cell, 20A Rue du Général Leclerc, Plobsheim, France., Savary CC; Institut National de la Santé et de la Recherche Médicale U991, Université de Rennes 1, Rennes, France., Hewitt PG; Non-Clinical Safety, Merck Serono, Merck KGaA, Darmstadt, Germany., Mueller SO; Non-Clinical Safety, Merck Serono, Merck KGaA, Darmstadt, Germany; Institut für Angewandte Biowissenschaften, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany., Guillouzo A; Institut National de la Santé et de la Recherche Médicale U991, Université de Rennes 1, Rennes, France., Richert L; Kaly-Cell, 20A Rue du Général Leclerc, Plobsheim, France., van Eijkeren JC; National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands., Hermens JL; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands., Blaauboer BJ; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2015 Dec 25; Vol. 30 (1 Pt A), pp. 52-61. Date of Electronic Publication: 2014 Nov 04.