Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Brodimoprim"'
Autor:
Mo Chen, Dapeng Peng, Han Xiaoya, Zonghui Yuan, Yanfei Tao, Saeed Ahmed, Yuanhu Pan, Feng Sheng, De-Xin Kong, Zhenli Liu, Yulian Wang
Publikováno v:
Food chemistry. 280
To monitor the abuse of antibacterial synergists, a hapten, trimethoprim carboxylic derivative (TMPCOOH), was designed by using molecular modelling technology. A broad-spectrum monoclonal antibody (mAb) TMP/2G1 was prepared, for which the IC50 values
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 36:372-383
A highly selective and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for the quantification of scicinib, a novel thiosemicarbazone analogue and anticancer agent in rat plasma. Protein precipitation with satu
Publikováno v:
Journal of Chromatography B. 871:78-89
A reliable liquid chromatography/tandem mass spectrometry has been developed for simultaneous evaluation of the activities of five cytochrome P450s (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A) in rat plasma and urine. The five-specific probe substrat
Publikováno v:
Chemical Research in Chinese Universities. 24:430-436
The present article covers a simple approach to detect and subsequently identify in vivo metabolites of brodimoprim, using high performance liquid chromatography coupled to ion trap mass spectrometer(LC/ESI-MS), which is based on a data-dependent acq
Publikováno v:
Journal of Pharmaceutical Sciences. 96:996-1007
The isolation and physicochemical characterization of four crystalline modifications of brodimoprim (5-[(4-bromo-3,5-dimethoxyphenyl)methyl]-2,4-pyrimidinediamine, hereinafter BMP), a structural analog of trimethoprim (TMP), are reported. These phase
Autor:
E. V. Cosmi, G. C. Di Renzo, F. Abate, L. Mearini, P.A.Monici Preti, G. Balsotti, F. Scarpello, R. Indraccolo, G. B. La Sala, E. Cirese, Massimo Minozzi, L. Cantini, Gianfranco Carlomagno
Publikováno v:
European Journal of Obstetrics & Gynecology and Reproductive Biology. 64:207-211
In an open study, 172 male and female adult patients with acute uncomplicated bacterial cystitis were randomly allocated to three treatment groups. Two groups received brodimoprim 200 mg tablets as follows: a single dose of two 200 mg tablets on day
Autor:
P. Veyssier, A. Bryskier
This chapter talks about dihydrofolate reductase inhibitors (DHFR), nitroheterocycles (furans), and 8-hydroxyquinolines. Trimethoprim and brodimoprim contain two nitrogen atoms on the pyrimidine ring which are easily protonable according to the pH of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f589bde4cd41698b06cd766764b4dd4e
https://doi.org/10.1128/9781555815929.ch35
https://doi.org/10.1128/9781555815929.ch35
Publikováno v:
Scopus-Elsevier
Dipalmitoylphosphatidylcholine vesicles were used as a biological membrane model to investigate the interaction and the permeation properties of trimethoprim and brodimoprim as a function of drug protonation. The drug-membrane interaction was studied
Publikováno v:
Antimicrobial Agents and Chemotherapy. 40:2392-2398
The entry of an antibiotic into phagocytes is a prerequisite for its intracellular bioactivity against susceptible facultative or obligatory intracellular microorganisms. Brodimoprim is a dimethoxybenzylpyrimidine that has recently entered into clini
Publikováno v:
Clinical Drug Investigation. 11:121-130
Brodimoprim is a diaminopyrimidine with a broad spectrum of antimicrobial activity in vitro, which includes activity against most common lower respiratory tract pathogens. The relative clinical efficacy of this agent was assessed in a meta-analysis o