Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss.

Autor: Liu H; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., Golji J; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., Brodeur LK; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., Chung FS; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., Chen JT; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., deBeaumont RS; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., Bullock CP; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., Jones MD; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., Kerr G; Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel, Switzerland., Li L; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., Rakiec DP; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., Schlabach MR; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., Sovath S; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., Growney JD; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., Pagliarini RA; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., Ruddy DA; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., MacIsaac KD; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., Korn JM; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA., McDonald ER 3rd; Novartis Institutes for Biomedical Research, Oncology Disease Area, Cambridge, MA, USA. rob.mcdonald@novartis.com.

Publikováno v: Nature medicine [Nat Med] 2019 Jan; Vol. 25 (1), pp. 95-102. Date of Electronic Publication: 2018 Dec 17.