Global overview of the management of acute cholecystitis during the COVID-19 pandemic (CHOLECOVID study)

Autor: Spiers H. V. M., Kouli O., Ahmed W. U., Varley R., Ahari D., Argus L., McLean K. A., Kamarajah S. K., Coe P., Griffiths E. A., Chan A. K. C., Macutkiewicz C., Jamdar S., Wilson M., Fullwood C., Toogood G., McLean K., Ahmed W., Gilchrist A., Goldsworthy M., Rashid M., Pockney P., Varela J., Brindl N., Ramirez J., Marafante C., Iwao Y., Ghzawi A., Elhadi M., Gacaferi H., Varghese C., Adeyeye A., Alser O., Teh C., Prieto M., Hasan A., Al-Naggar H., Salgado R., Veracierto F., Lancelotti T., Solinas D., Oddi R., Garcia F. W., Mazza Diez E., Andrade Ramirez M. R., Bracco R., Fernandez D., Maraschio M. A., Obeide L., Giordano E., Alcaraz A., Marani M. A., Aguirre N., Luna F., Francesconi M., Chiham F., Ramos Cossio R., Alvarez F. A., Pantoja Pachajoa D. A., Mandojana F., Merlo I. G., Gonzalez M. H., Cervelo G., Puma R., Vardaro G. F., Davis A., Jurat D., Guenoff C., Raubenheimer K., Goddard K., Brown K., Wegrecki K. J., Cheung H. Y. C., Yang M., Cheung H., Siddiqui J., Ahn J. H., Huynh R., Lam Y. H., Afzal M., Ong B. S., Chua M. Y. M., Ly K., Thomson J. E., Watson D., Dawson A. C., Drane A., Van Ruyven S., Lun E. W. Y., Ferguson M., Jeong J. Y., De Silva C., Wills V., Gundara J., McCourt E., Bong C., Tabone R., Wong W. J., Gray A., Koh D., Pollock M., Singhal S., Smith R., Dudi-Venkata N. N., Kanhere H., Stranz C., Seow W., Mansour L. T., Wormald J., Loveday B. P. T., Thomson B., O'Donnell T., Milenkovski N., Herath M., Trochsler M., Farfus A., Maddern G., Bunjo Z., Kuan L. L., Atanasov G., Dawson A., Lun E., Samadov E., Namazov I., Asgarov M., Ibrahimli A., Srinivasan M., Saeed M. F., Aljawder H., Juma I., Coimbra F. J., Marques N., Casteleins W. A., Petruzziello A., Jabur G., Rodriguez J. F. P., Buso P. L., Mackenzie S., Hsiao M., Sljivic I., Tecson A., Karanicolas P. J., Roke R., Moon J., Butler E. V., Riquelme F., Yanez M., Catan F., Uribe M., Carriel F., Oppliger F., Paredes A., Daroch D., Aguayo J. C., Perez Rivera C. J., Acosta Buitrago L. 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Publikováno v: BJS Open, 6(3):zrac052. John Wiley & Sons Ltd.
BJS open, Oxford : Oxford University Press, 2022, vol. 6, no. 3, art. no. zrac052, p. [1-9]

Background This study provides a global overview of the management of patients with acute cholecystitis during the initial phase of the COVID-19 pandemic. Methods CHOLECOVID is an international, multicentre, observational comparative study of patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d607470519304403ad13385bfde779a
https://hdl.handle.net/11585/902944

SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response.

Autor: Bland P; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Saville H; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Wai PT; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Curnow L; Division of Cancer Biology, The Institute of Cancer Research, London, UK., Muirhead G; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Nieminuszczy J; Division of Cancer Biology, The Institute of Cancer Research, London, UK., Ravindran N; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., John MB; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Hedayat S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Barker HE; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.; Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia., Wright J; Division of Cancer Biology, The Institute of Cancer Research, London, UK., Yu L; Division of Cancer Biology, The Institute of Cancer Research, London, UK., Mavrommati I; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Read A; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Peck B; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.; Translational Cancer Metabolism Team, Centre for Tumour Biology, Barts Cancer Institute, Cancer Research UK Centre of Excellence, Queen Mary University of London, Charterhouse Square, London, UK., Allen M; Biological Services Unit, The Institute of Cancer Research, London, UK., Gazinska P; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Pemberton HN; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.; The Cancer Research UK Gene Function Laboratory, The Institute of Cancer Research, London, UK., Gulati A; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.; The Cancer Research UK Gene Function Laboratory, The Institute of Cancer Research, London, UK., Nash S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Noor F; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Guppy N; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Roxanis I; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Pratt G; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Oldreive C; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Stankovic T; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Barlow S; Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK., Kalirai H; Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK., Coupland SE; Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK., Broderick R; Division of Cancer Biology, The Institute of Cancer Research, London, UK., Alsafadi S; Inserm U830, PSL University, Institut Curie, Paris, France., Houy A; Inserm U830, PSL University, Institut Curie, Paris, France., Stern MH; Inserm U830, PSL University, Institut Curie, Paris, France., Pettit S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.; The Cancer Research UK Gene Function Laboratory, The Institute of Cancer Research, London, UK., Choudhary JS; Division of Cancer Biology, The Institute of Cancer Research, London, UK., Haider S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Niedzwiedz W; Division of Cancer Biology, The Institute of Cancer Research, London, UK., Lord CJ; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.; The Cancer Research UK Gene Function Laboratory, The Institute of Cancer Research, London, UK., Natrajan R; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK. rachael.natrajan@icr.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2023 Aug; Vol. 55 (8), pp. 1311-1323. Date of Electronic Publication: 2023 Jul 31.

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Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2's nuclease activity.

Autor: Broderick R; The Institute of Cancer Research, London, UK., Cherdyntseva V; Laboratory of Genetics, Center of Clinical Research, Experimental Surgery and Translational Research Biomedical Research Foundation Academy of Athens (BRFAA), Athens, Greece., Nieminuszczy J; The Institute of Cancer Research, London, UK., Dragona E; Laboratory of Genetics, Center of Clinical Research, Experimental Surgery and Translational Research Biomedical Research Foundation Academy of Athens (BRFAA), Athens, Greece., Kyriakaki M; Laboratory of Genetics, Center of Clinical Research, Experimental Surgery and Translational Research Biomedical Research Foundation Academy of Athens (BRFAA), Athens, Greece., Evmorfopoulou T; Laboratory of Genetics, Center of Clinical Research, Experimental Surgery and Translational Research Biomedical Research Foundation Academy of Athens (BRFAA), Athens, Greece., Gagos S; Laboratory of Genetics, Center of Clinical Research, Experimental Surgery and Translational Research Biomedical Research Foundation Academy of Athens (BRFAA), Athens, Greece. sgagos@bioacademy.gr., Niedzwiedz W; The Institute of Cancer Research, London, UK. wojciech.niedzwiedz@icr.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2023 Apr 27; Vol. 14 (1), pp. 2428. Date of Electronic Publication: 2023 Apr 27.

SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance.

Autor: Llorca-Cardenosa MJ; The Institute of Cancer Research, London, United Kingdom., Aronson LI; The Institute of Cancer Research, London, United Kingdom., Krastev DB; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, United Kingdom.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom., Nieminuszczy J; The Institute of Cancer Research, London, United Kingdom., Alexander J; The Institute of Cancer Research, London, United Kingdom., Song F; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, United Kingdom.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom., Dylewska M; The Institute of Cancer Research, London, United Kingdom., Broderick R; The Institute of Cancer Research, London, United Kingdom., Brough R; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, United Kingdom.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom., Zimmermann A; The healthcare business of Merck KGaA, Biopharma R&D, Translational Innovation Platform Oncology, Darmstadt, Germany., Zenke FT; The healthcare business of Merck KGaA, Biopharma R&D, Translational Innovation Platform Oncology, Darmstadt, Germany., Gurel B; The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom., Riisnaes R; The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom., Ferreira A; The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom., Roumeliotis T; The Institute of Cancer Research, London, United Kingdom., Choudhary J; The Institute of Cancer Research, London, United Kingdom., Pettitt SJ; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, United Kingdom.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom., de Bono J; The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom., Cervantes A; Department of Medical Oncology, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, 46010, Spain.; CIBERONC, Instituto de Salud Carlos III, Madrid, Spain., Haider S; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom., Niedzwiedz W; The Institute of Cancer Research, London, United Kingdom., Lord CJ; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, United Kingdom.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom., Chong IY; The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom.

Publikováno v: Cancer research [Cancer Res] 2022 Nov 02; Vol. 82 (21), pp. 3962-3973.