Correction to "MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery".

Autor: Brocklehurst CE; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland., Altmann E; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland., André J; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland., Bon C; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland., Caya T; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Davis H; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland., Decoret O; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland., Dunstan D; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Ertl P; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland., Ginsburg-Moraff C; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Grob J; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Gosling DJ; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland., Lapointe G; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland., Majumdar D; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Marziale AN; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland., Mues H; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland., Palmieri M; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland., Racine S; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland., Robinson RI; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Springer C; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Tan K; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Ulmer W; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., West L; Discovery Sciences, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Wyler R; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Mar 28; Vol. 67 (6), pp. 5111-5112. Date of Electronic Publication: 2024 Mar 12.

High-throughput synthesis provides data for predicting molecular properties and reaction success.

Autor: Götz J; Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093 Zürich, Switzerland., Jackl MK; Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093 Zürich, Switzerland., Jindakun C; Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093 Zürich, Switzerland., Marziale AN; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., André J; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Gosling DJ; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Springer C; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Cambridge, MA 02139, USA., Palmieri M; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Reck M; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Luneau A; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Brocklehurst CE; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Bode JW; Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093 Zürich, Switzerland.

Publikováno v: Science advances [Sci Adv] 2023 Oct 27; Vol. 9 (43), pp. eadj2314. Date of Electronic Publication: 2023 Oct 27.

Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors.

Autor: Sellner H; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Chapeau E; Oncology Drug Discovery, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Furet P; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Voegtle M; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Salem B; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Le Douget M; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Bordas V; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Groell JM; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Le Goff AL; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Rouzet C; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Wietlisbach T; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Zimmermann T; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., McKenna J; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Brocklehurst CE; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Chène P; Oncology Drug Discovery, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Wartmann M; Oncology Drug Discovery, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Scheufler C; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Kallen J; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Williams G; Pharmacokinetics Sciences, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Harlfinger S; Pharmacokinetics Sciences, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Traebert M; Preclinical Safety, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Dumotier BM; Preclinical Safety, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Schmelzle T; Oncology Drug Discovery, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland., Soldermann N; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, 4002, Switzerland.

Publikováno v: ChemMedChem [ChemMedChem] 2023 Jun 01; Vol. 18 (11), pp. e202300051. Date of Electronic Publication: 2023 Apr 13.

Reliable Functionalization of 5,6-Fused Bicyclic N-Heterocycles Pyrazolopyrimidines and Imidazopyridazines via Zinc and Magnesium Organometallics.

Autor: Kumar Rout S; Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, München, Germany., Kastrati A; Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, München, Germany., Jangra H; Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, München, Germany., Schwärzer K; Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, München, Germany., Sunagatullina AS; Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, München, Germany., Garny M; Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, München, Germany., Lima F; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 4057, Basel, Switzerland., Brocklehurst CE; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 4057, Basel, Switzerland., Karaghiosoff K; Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, München, Germany., Zipse H; Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, München, Germany., Knochel P; Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, München, Germany.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2022 Jun 10; Vol. 28 (33), pp. e202200733. Date of Electronic Publication: 2022 May 11.

Building bridges.

Autor: Brocklehurst CE; Global Discovery Chemistry Department, Novartis Institutes for Biomedical Research, Basel, Switzerland. cara.brocklehurst@novartis.com., Anderson EA; Department of Chemistry, University of Oxford, Oxford, UK.

Publikováno v: Nature chemistry [Nat Chem] 2021 Oct; Vol. 13 (10), pp. 928-930.