Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Brock McKinney"'
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 18, Iss 1, Pp 1-4 (2022)
Abstract Background Since the first reported case of COVID-19, infections due to the virus have ranged from mild to severe. Patients with inborn errors of immunity are thought to be at increased risk for infections such as COVID-19 due to the nature
Externí odkaz:
https://doaj.org/article/d1b885682af94db1ad51da02d02e00bd
Autor:
Andrea Walens, Jiaxing Lin, Jeffrey S. Damrauer, Brock McKinney, Ryan Lupo, Rachel Newcomb, Douglas B. Fox, Nathaniel W. Mabe, Jeremy Gresham, Zhecheng Sheng, Alexander B. Sibley, Tristan De Buysscher, Hemant Kelkar, Piotr A. Mieczkowski, Kouros Owzar, James V. Alvarez
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The cellular composition of recurrent tumors can provide insight into resistance to therapy and inform on second line therapies. Here, using a genetically modified mouse, the authors perform barcoding experiments of the primary tumors to allow them t
Externí odkaz:
https://doaj.org/article/88169f662d1448619437707b70a98494
Autor:
Elizabeth A Mendes, Sarah C. Van Alsten, Jeremy Force, Brock McKinney, Ashley V. DiMarco, Kouros Owzar, Jichun Xie, Nina Marie G. Garcia, Melissa A. Troester, Xiaodi Qin, Brent A. Hanks, James V. Alvarez
Publikováno v:
Cancer Immunol Res
The APOBEC family of cytidine deaminases is one of the most common endogenous sources of mutations in human cancer. Genomic studies of tumors have found that APOBEC mutational signatures are enriched in the HER2 subtype of breast cancer and are assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670dda4cfc886812db9e0206bb981320
https://doi.org/10.1158/2326-6066.cir-21-0146
https://doi.org/10.1158/2326-6066.cir-21-0146
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
Whole-genome duplication (WGD) generates polyploid cells possessing more than two copies of the genome and is among the most common genetic abnormalities in cancer. The frequency of WGD increases in advanced and metastatic tumors, and WGD is associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade48fd37344b2f5955e2bdc7cd875f7
https://doaj.org/article/697de7b1dc5d4dff8c6dee6e6e68404d
https://doaj.org/article/697de7b1dc5d4dff8c6dee6e6e68404d
Autor:
Jason W. Locasale, Laura C. Noteware, Brock McKinney, Ryan Lupo, Rachel Newcomb, James V. Alvarez, Douglas B. Fox, Matthew D. Hirschey, Juan Liu, Nina Marie G. Garcia
Publikováno v:
Nature metabolism
The survival and recurrence of dormant tumour cells following therapy is a leading cause of death in cancer patients. The metabolic properties of these cells are likely distinct from those of rapidly growing tumours. Here we show that Her2 down-regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4860d5011e278d465396eada26ac6150
http://europepmc.org/articles/PMC7370851
http://europepmc.org/articles/PMC7370851
Autor:
Brock McKinney, Xiaodi Qin, Sarah C. Van Alsten, Kouros Owzar, Nina Marie G. Garcia, Ashley V. DiMarco, James V. Alvarez, Brent A. Hanks, Jeremy Force, Melissa A. Troester, Jichun Xie
The APOBEC family of cytidine deaminases is one of the most common endogenous sources of mutations in human cancer. Genomic studies of tumors have found that APOBEC mutational signatures are particularly enriched in the HER2 subtype of breast cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75787fbd7b5696e6d415f1f7f0cb9199
https://doi.org/10.1101/2021.02.13.431068
https://doi.org/10.1101/2021.02.13.431068
Autor:
Zhecheng Sheng, Hemant Kelkar, Brock McKinney, Kouros Owzar, Tristan De Buysscher, Nathaniel W. Mabe, Rachel Newcomb, Ryan Lupo, Piotr A. Mieczkowski, Andrea Walens, Jeffrey S. Damrauer, Alexander B. Sibley, Jeremy Gresham, Douglas B. Fox, Jiaxing Lin, James V. Alvarez
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The survival and recurrence of residual tumor cells following therapy constitutes one of the biggest obstacles to obtaining cures in breast cancer, but it remains unclear how the clonal composition of tumors changes during relapse. We use cellular ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec100826d6dbb32fe10bb9a2b48d1e0
https://pubmed.ncbi.nlm.nih.gov/33024122
https://pubmed.ncbi.nlm.nih.gov/33024122
Autor:
Ashley V. DiMarco, Ryan Lupo, Brock McKinney, Xiaodi Qin, James V. Alvarez, Jichun Xie, Kouros Owzar
Publikováno v:
Cancer Immunology Research. 9:PO002-PO002
APOBEC-mediated mutagenesis is one of the most common endogenous sources of mutations in human cancer. APOBEC mutations are due to the episodic activity of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family of cytidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2858dff1f9aed495e650be8b593da373
https://doi.org/10.1158/2326-6074.tumimm20-po002
https://doi.org/10.1158/2326-6074.tumimm20-po002
Autor:
Brock McKinney, Gary Foster, Eleanor Pullenayegum, Sarah D. McDonald, Olha Lutsiv, Valerie H. Taylor
Publikováno v:
International Journal of Obesity. 39:1710-1716
Obesity and depression have become prevalent pregnancy complications, individually associated with adverse perinatal health outcomes. Despite the co-prevalence of these two risk factors, their combined effects on maternal health are yet to be studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511cc24711f09577233d55e6be10ce94
https://doi.org/10.1038/ijo.2015.119
https://doi.org/10.1038/ijo.2015.119
Autor:
Brock McKinney, Olha Lutsiv, Valerie H. Taylor, Eleanor Pullenayegum, Gary Foster, Sarah D. McDonald
Publikováno v:
International Journal of Obesity. 39:1033-1040
Maternal overweight/obesity and depression are among the most prevalent pregnancy complications, and although individually they are associated with poor pregnancy outcomes, their combined effects are unknown. Owing to this, the objective of this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f67808c8cb62ff55f3979665c0c139
https://doi.org/10.1038/ijo.2015.44
https://doi.org/10.1038/ijo.2015.44