Výsledky vyhledávání - "Brock A. Martin"

Akademický článek

Flavinated SDHA underlies the change in intrinsic optical properties of oral cancers

Autor: Tomoko Marumo, Chima V. Maduka, Evran Ural, Ehsanul Hoque Apu, Seock-Jin Chung, Koji Tanabe, Nynke S. van den Berg, Quan Zhou, Brock A. Martin, Tadashi Miura, Eben L. Rosenthal, Takahiko Shibahara, Christopher H. Contag

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)

Abstract The molecular basis of reduced autofluorescence in oral squamous cell carcinoma (OSCC) cells relative to normal cells has been speculated to be due to lower levels of free flavin adenine dinucleotide (FAD). This speculation, along with diffe

Externí odkaz: https://doaj.org/article/db37e6deb74d46b8a147fa7635fece47

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Akademický článek

Temporal increase in the incidence of anal squamous cell carcinoma in Kentucky and factors associated with adverse outcomes

Autor: Stephen J. O'brien, Jeremy T. Gaskins, C. Tyler Ellis, Brock A. Martin, Jaclyn Mcdowell, Dibson Dibe Gondim, Susan Galandiuk

Publikováno v: Cancer Medicine, Vol 12, Iss 10, Pp 11462-11474 (2023)

Abstract Background Anal squamous cell cancer (ASCC) incidence in Kentucky is increasing at an alarming rate. In 2009, the incidence surpassed the US national average (2.66 vs. 1.77/100,000 people), and currently, Kentucky ranks second by state per c

Externí odkaz: https://doaj.org/article/6321c538d5fe4b0f8116b59af4c3d92b

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Akademický článek

Co-administered antibody improves penetration of antibody–dye conjugate into human cancers with implications for antibody–drug conjugates

Autor: Guolan Lu, Naoki Nishio, Nynke S. van den Berg, Brock A. Martin, Shayan Fakurnejad, Stan van Keulen, Alexander D. Colevas, Greg M. Thurber, Eben L. Rosenthal

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Antibody-drug conjugates targeting high expression receptors can suffer from poor tumour penetration. Here, the authors use unconjugated antibody to improve the penetration of an antibody-dye conjugate in a clinical study, supporting further clinical

Externí odkaz: https://doaj.org/article/1938690d6e61435ab3bfc4f49f1afa68

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Akademický článek

Impact of a deep learning assistant on the histopathologic classification of liver cancer

Publikováno v: npj Digital Medicine, Vol 3, Iss 1, Pp 1-8 (2020)

Abstract Artificial intelligence (AI) algorithms continue to rival human performance on a variety of clinical tasks, while their actual impact on human diagnosticians, when incorporated into clinical workflows, remains relatively unexplored. In this

Externí odkaz: https://doaj.org/article/615de5de8f5543b69db4c81e88e47231

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Akademický článek

Case Report: Syphilitic Hepatitis–A Rare and Underrecognized Etiology of Liver Disease With Potential for Misdiagnosis

Autor: Hiba A. Al Dallal, Siddharth Narayanan, Hanah F. Alley, Michael J. Eiswerth, Forest W. Arnold, Brock A. Martin, Alaleh E. Shandiz

Publikováno v: Frontiers in Medicine, Vol 8 (2021)

Syphilitic hepatitis (SH) in adults is a rare condition that can be easily misdiagnosed. Clinical and histopathologic manifestations of SH can mimic other infectious and non-infectious conditions, and the diagnosis should be considered in all at-risk

Externí odkaz: https://doaj.org/article/1b51ff2862e3467ca95400f9fe021c50

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Akademický článek

Pulmonary large cell neuroendocrine carcinoma (LCNEC) with confirmed liver metastases negative on 18F-FDG and 68Ga-DOTATATE PET

Autor: Gaia Ninatti, Heying Duan, MD, Valentina Ferri, MS, Brock A. Martin, MD, Carina Mari Aparici, MD

Publikováno v: Radiology Case Reports, Vol 15, Iss 12, Pp 2698-2700 (2020)

Lung neuroendocrine neoplasms (NENs) encompass the low-, intermediate-, and high-grade entities. Differentiated NENs overexpress somatostatin receptors, which are targeted by 68Ga-DOTA-conjugated peptides in molecular imaging with positron emission t

Externí odkaz: https://doaj.org/article/007a2e35077e4afca0154582db3c1eed

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Akademický článek

Optical molecular imaging can differentiate metastatic from benign lymph nodes in head and neck cancer

Autor: Naoki Nishio, Nynke S. van den Berg, Stan van Keulen, Brock A. Martin, Shayan Fakurnejad, Nutte Teraphongphom, Stefania U. Chirita, Nicholas J. Oberhelman, Guolan Lu, Crista E. Horton, Michael J. Kaplan, Vasu Divi, A. Dimitrios Colevas, Eben L. Rosenthal

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

Imaging metastatic disease burden in lymph nodes is important for surgical decision making. Here, the authors use an antibody-dye conjugate to distinguish between metastatic and benign lymph nodes in head and neck cancer.

Externí odkaz: https://doaj.org/article/9d94d112023644caad227f072f22a399

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Akademický článek

Intraoperative Molecular Imaging for ex vivo Assessment of Peripheral Margins in Oral Squamous Cell Carcinoma

Autor: Shayan Fakurnejad, Giri Krishnan, Stan van Keulen, Naoki Nishio, Andrew C. Birkeland, Fred M. Baik, Michael J. Kaplan, A. Dimitrios Colevas, Nynke S. van den Berg, Eben L. Rosenthal, Brock A. Martin

Publikováno v: Frontiers in Oncology, Vol 9 (2020)

Objective: Complete surgical resection is the standard of care for treatment of oral cancer although the positive margin rate remains 15–30%. Tissue sampling from the resected specimen and from the wound bed for frozen section analysis (FSA) remain

Externí odkaz: https://doaj.org/article/61d5bdfe3afb4f58bafcdefc77a80b27

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