Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Broadstock, Martin"'
Autor:
Killick, Richard, Elliott, Christina, Ribe, Elena, Broadstock, Martin, Ballard, Clive, Aarsland, Dag, Williams, Gareth
Publikováno v:
International Journal of Molecular Sciences; Jul2023, Vol. 24 Issue 13, p11219, 15p
Autor:
Ash, Elizabeth S., Alavijeh, Mohammad S., Palmer, Alan M., Mitchelmore, Cathy, Howlett, David R., Francis, Paul T., Broadstock, Martin, Richardson, Jill C.
Publikováno v:
In Neurochemistry International November 2010 57(5):504-511
Autor:
Elliott, Christina Louise, Rojo, Ana I, Ribe, Elena, Broadstock, Martin, Xia, Weiming, Mornin, Peter, Semenov, mMikhail, Baillie, George, Cuadrado, Antonio, Al-Shawi, Raya, Ballard, Clive Gerald, Simons, Paul, Killick, Richard
Publikováno v:
Elliott, C L, Rojo, A I, Ribe, E, Broadstock, M, Xia, W, Mornin, P, Semenov, MM, Baillie, G, Cuadrado, A, Al-Shawi, R, Ballard, C G, Simons, P & Killick, R 2018, ' A role for APP in Wnt signalling links synapse loss with β-amyloid production : Aβ synaptotoxicity drives Aβ production ', Translational psychiatry, vol. 8, no. 1, 179 . https://doi.org/10.1038/s41398-018-0231-6
In Alzheimer’s disease (AD), the canonical Wnt inhibitor Dickkopf-1 (Dkk1) is induced by β-amyloid (Aβ) and shifts the balance from canonical towards non-canonical Wnt signalling. Canonical (Wnt-β-catenin) signalling promotes synapse stability,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2761::e60324fbda4fd9452dab507f1fd82a0b
https://kclpure.kcl.ac.uk/ws/files/147552094/A_role_for_APP_in_Wnt_signalling_links_KILLICK_Publishedonline20September2018_GOLD_VoR_CC_BY_.pdf
https://kclpure.kcl.ac.uk/ws/files/147552094/A_role_for_APP_in_Wnt_signalling_links_KILLICK_Publishedonline20September2018_GOLD_VoR_CC_BY_.pdf
Autor:
Elliott, Christina, Rojo, Ana I., Ribe, Elena, Broadstock, Martin, Xia, Weiming, Morin, Peter, Semenov, Mikhail, Baillie, George, Cuadrado, Antonio, Al-Shawi, Raya, Ballard, Clive G., Simons, Paul, Killick, Richard
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Translational Psychiatry, Vol 8, Iss 1, Pp 1-13 (2018)
Consejería de Sanidad de la Comunidad de Madrid
Translational Psychiatry, Vol 8, Iss 1, Pp 1-13 (2018)
In Alzheimer’s disease (AD), the canonical Wnt inhibitor Dickkopf-1 (Dkk1) is induced by β-amyloid (Aβ) and shifts the balance from canonical towards non-canonical Wnt signalling. Canonical (Wnt-β-catenin) signalling promotes synapse stability,
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Alghamdi, Amani, Vallortigara, Julie, Howlett, David R, Broadstock, Martin, Hortobágyi, Tibor, Ballard, Clive, Thomas, Alan J, O'Brien, John T, Aarsland, Dag, Attems, Johannes, Francis, Paul T, Whitfield, David R
Publikováno v:
Alghamdi, A, Vallortigara, J, Howlett, D R, Broadstock, M, Hortobágyi, T, Ballard, C, Thomas, A J, O'Brien, J T, Aarsland, D, Attems, J, Francis, P T & Whitfield, D R 2017, ' Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia ', JOURNAL OF ALZHEIMERS DISEASE, vol. 57, no. 2, DOI 10.3233/JAD-160946, pp. 373-386 . https://doi.org/10.3233/JAD-160946
Lewy body dementia is the second most common neurodegenerative dementia and is pathologically characterized by α-synuclein positive cytoplasmic inclusions, with varying amounts of amyloid-β (Aβ) and hyperphosphorylated tau (tau) aggregates in addi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa188c80483520b75524bc3038e87b1b
Publikováno v:
Human Gene Therapy; Vol 23
Publikováno v:
EXCLI Journal
Amyloid-β peptides and hyper-phosphorylated tau are the main pathological hallmarks of Alzheimer's disease (AD). Given the recent failure of several large-scale clinical trials and the lack of disease-modifying pharmacological treatments, there is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae4f52b445b82278edb9d59542f0f97
http://hdl.handle.net/2003/35056
http://hdl.handle.net/2003/35056