Neurodegenerative Disease Associated Pathways in the Brains of Triple Transgenic Alzheimer's Model Mice Are Reversed Following Two Weeks of Peripheral Administration of Fasudil.

Autor: Killick, Richard, Elliott, Christina, Ribe, Elena, Broadstock, Martin, Ballard, Clive, Aarsland, Dag, Williams, Gareth

Publikováno v: International Journal of Molecular Sciences; Jul2023, Vol. 24 Issue 13, p11219, 15p

A role for APP in Wnt signalling links synapse loss with β-amyloid production:Aβ synaptotoxicity drives Aβ production

Autor: Elliott, Christina Louise, Rojo, Ana I, Ribe, Elena, Broadstock, Martin, Xia, Weiming, Mornin, Peter, Semenov, mMikhail, Baillie, George, Cuadrado, Antonio, Al-Shawi, Raya, Ballard, Clive Gerald, Simons, Paul, Killick, Richard

Publikováno v: Elliott, C L, Rojo, A I, Ribe, E, Broadstock, M, Xia, W, Mornin, P, Semenov, MM, Baillie, G, Cuadrado, A, Al-Shawi, R, Ballard, C G, Simons, P & Killick, R 2018, ' A role for APP in Wnt signalling links synapse loss with β-amyloid production : Aβ synaptotoxicity drives Aβ production ', Translational psychiatry, vol. 8, no. 1, 179 . https://doi.org/10.1038/s41398-018-0231-6

In Alzheimer’s disease (AD), the canonical Wnt inhibitor Dickkopf-1 (Dkk1) is induced by β-amyloid (Aβ) and shifts the balance from canonical towards non-canonical Wnt signalling. Canonical (Wnt-β-catenin) signalling promotes synapse stability,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2761::e60324fbda4fd9452dab507f1fd82a0b
https://kclpure.kcl.ac.uk/ws/files/147552094/A_role_for_APP_in_Wnt_signalling_links_KILLICK_Publishedonline20September2018_GOLD_VoR_CC_BY_.pdf

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Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia

Autor: Alghamdi, Amani, Vallortigara, Julie, Howlett, David R, Broadstock, Martin, Hortobágyi, Tibor, Ballard, Clive, Thomas, Alan J, O'Brien, John T, Aarsland, Dag, Attems, Johannes, Francis, Paul T, Whitfield, David R

Publikováno v: Alghamdi, A, Vallortigara, J, Howlett, D R, Broadstock, M, Hortobágyi, T, Ballard, C, Thomas, A J, O'Brien, J T, Aarsland, D, Attems, J, Francis, P T & Whitfield, D R 2017, ' Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia ', JOURNAL OF ALZHEIMERS DISEASE, vol. 57, no. 2, DOI 10.3233/JAD-160946, pp. 373-386 . https://doi.org/10.3233/JAD-160946

Lewy body dementia is the second most common neurodegenerative dementia and is pathologically characterized by α-synuclein positive cytoplasmic inclusions, with varying amounts of amyloid-β (Aβ) and hyperphosphorylated tau (tau) aggregates in addi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa188c80483520b75524bc3038e87b1b

A genetically immortalized human stem cell line: a promising new tool for Alzheimer's disease therapy

Autor: Puangmalai, Nicha, Somani, Alyma, Thangnipon, Wipawan, Ballard, Clive, Broadstock, Martin

Publikováno v: EXCLI Journal

Amyloid-β peptides and hyper-phosphorylated tau are the main pathological hallmarks of Alzheimer's disease (AD). Given the recent failure of several large-scale clinical trials and the lack of disease-modifying pharmacological treatments, there is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae4f52b445b82278edb9d59542f0f97
http://hdl.handle.net/2003/35056