OnPLS-Based Multi-Block Data Integration : A Multivariate Approach to Interrogating Biological Interactions in Asthma

Autor: Reinke, SN, Galindo-Prieto, B, Skotare, T, Broadhurst, DI, Singhania, A, Horowitz, D, Djukanovic, R, Hinks, TSC, Geladi, P, Trygg, J, Wheelock, CE

Publikováno v: Analytical Chemistry

Integration of multiomics data remains a key challenge in fulfilling the potential of comprehensive systems biology. Multiple-block orthogonal projections to latent structures (OnPLS) is a Multi projection method that simultaneously models multiple d

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http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-154351

Gestation-specific D-dimer reference ranges: a cross-sectional study.

Autor: Murphy, N, Broadhurst, DI, Khashan, AS, Gilligan, O, Kenny, LC, O'Donoghue, K

Publikováno v: BJOG: An International Journal of Obstetrics & Gynaecology; Feb2015, Vol. 122 Issue 3, p395-400, 6p, 2 Charts, 1 Graph

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Maternal serum cholesterol levels are elevated from the 1st trimester of pregnancy: A cross-sectional study.

Autor: Bartels A, Egan N, Broadhurst DI, Khashan AS, Joyce C, Stapleton M, O'Mullane J, O'Donoghue K

Publikováno v: Journal of Obstetrics & Gynaecology; Nov2012, Vol. 32 Issue 8, p747-752, 6p

Metabolite signatures associated with microRNA miR-143-3p serve as drivers of poor lung function trajectories in childhood asthma.

Autor: Mendez KM; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Centre for Integrative Metabolomics & Computational Biology, School of Science, Edith Cowan University, Perth, Australia., Begum S; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Tiwari A; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Sharma R; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Chen Q; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Kelly RS; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Prince N; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Huang M; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Kachroo P; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Chu SH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Chen Y; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Lee-Sarwar K; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Broadhurst DI; Centre for Integrative Metabolomics & Computational Biology, School of Science, Edith Cowan University, Perth, Australia., Reinke SN; Centre for Integrative Metabolomics & Computational Biology, School of Science, Edith Cowan University, Perth, Australia., Gerszten R; Department of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Clish C; Broad Institute, Cambridge, MA, USA., Avila L; Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA., Celedón JC; Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA., Wheelock CE; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden., Weiss ST; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., McGeachie M; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Lasky-Su JA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: rejas@channing.harvard.edu.

Publikováno v: EBioMedicine [EBioMedicine] 2024 Apr; Vol. 102, pp. 105025. Date of Electronic Publication: 2024 Mar 07.