Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis.

Autor: Poon MM; Contineum Therapeutics, San Diego, CA 92121., Lorrain KI; Contineum Therapeutics, San Diego, CA 92121., Stebbins KJ; Contineum Therapeutics, San Diego, CA 92121., Edu GC; Contineum Therapeutics, San Diego, CA 92121., Broadhead AR; Contineum Therapeutics, San Diego, CA 92121., Lorenzana AJ; Contineum Therapeutics, San Diego, CA 92121., Roppe JR; Contineum Therapeutics, San Diego, CA 92121., Baccei JM; Contineum Therapeutics, San Diego, CA 92121., Baccei CS; Contineum Therapeutics, San Diego, CA 92121., Chen AC; Contineum Therapeutics, San Diego, CA 92121., Green AJ; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158., Lorrain DS; Contineum Therapeutics, San Diego, CA 92121., Chan JR; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Aug 06; Vol. 121 (32), pp. e2407974121. Date of Electronic Publication: 2024 Jul 31.

In vitro and in vivo pharmacology of NXT629, a novel and selective PPARα antagonist.

Autor: Stebbins KJ; Inception Sciences, 5871 Oberlin Drive, Suite 100, San Diego, CA 92121, United States. Electronic address: Kstebbins@inceptionsci.com., Broadhead AR; Inception Sciences, 5871 Oberlin Drive, Suite 100, San Diego, CA 92121, United States., Cabrera G; Inception Sciences, 5871 Oberlin Drive, Suite 100, San Diego, CA 92121, United States., Correa LD; Inception Sciences, 5871 Oberlin Drive, Suite 100, San Diego, CA 92121, United States., Messmer D; Inception Sciences, 5871 Oberlin Drive, Suite 100, San Diego, CA 92121, United States., Bundey R; Inception Sciences, 5871 Oberlin Drive, Suite 100, San Diego, CA 92121, United States., Baccei C; Inception Sciences, 5871 Oberlin Drive, Suite 100, San Diego, CA 92121, United States., Bravo Y; Inception Sciences, 5871 Oberlin Drive, Suite 100, San Diego, CA 92121, United States., Chen A; Inception Sciences, 5871 Oberlin Drive, Suite 100, San Diego, CA 92121, United States., Stock NS; Inception Sciences, 5871 Oberlin Drive, Suite 100, San Diego, CA 92121, United States., Prasit P; Inception Sciences, 5871 Oberlin Drive, Suite 100, San Diego, CA 92121, United States., Lorrain DS; Inception Sciences, 5871 Oberlin Drive, Suite 100, San Diego, CA 92121, United States.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2017 Aug 15; Vol. 809, pp. 130-140. Date of Electronic Publication: 2017 May 05.

Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation.

Autor: Bain G; Amira Pharmaceuticals, San Diego, California 92121, USA. gretchen.bain@amirapharm.com, Lorrain DS, Stebbins KJ, Broadhead AR, Santini AM, Prodanovich P, Darlington J, King CD, Lee C, Baccei C, Stearns B, Troung Y, Hutchinson JH, Prasit P, Evans JF

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2011 Jul; Vol. 338 (1), pp. 290-301. Date of Electronic Publication: 2011 Apr 12.

Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation.

Autor: Lorrain DS; Amira Pharmaceuticals, 9535 Waples Street, Ste. 100, San Diego, California 92121, USA. dan.lorrain@amirapharm.com, Bain G, Correa LD, Chapman C, Broadhead AR, Santini AM, Prodanovich PP, Darlington JV, Stock NS, Zunic J, King CD, Lee C, Baccei CS, Stearns B, Roppe J, Hutchinson JH, Prasit P, Evans JF

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2010 Aug 25; Vol. 640 (1-3), pp. 211-8. Date of Electronic Publication: 2010 May 21.

Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung.

Autor: Stebbins KJ; Amira Pharmaceuticals, 9535 Waples St. Ste. 100, San Diego, CA 92121, USA. Karin.stebbins@amirapharm.com, Broadhead AR, Baccei CS, Scott JM, Truong YP, Coate H, Stock NS, Santini AM, Fagan P, Prodanovich P, Bain G, Stearns BA, King CD, Hutchinson JH, Prasit P, Evans JF, Lorrain DS

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2010 Mar; Vol. 332 (3), pp. 764-75. Date of Electronic Publication: 2009 Dec 08.