Ubiquitin-mediated recruitment of the ATG9A-ATG2 lipid transfer complex drives clearance of phosphorylated p62 aggregates.

Autor: Broadbent DG; Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI, USA.; College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.; Department of Physiology, College of Natural Sciences, Michigan State University, East Lansing, MI, USA., McEwan CM; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA., Jayatunge D; Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Kaminsky EG; Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI, USA., Tsang TM; Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Poole DM; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA., Naylor BC; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA., Price JC; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA., Schmidt JC; Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, MI, USA., Andersen JL; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.; Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.

Publikováno v: Molecular biology of the cell [Mol Biol Cell] 2024 Dec 24, pp. mbcE24030101. Date of Electronic Publication: 2024 Dec 24.

The formation of ubiquitin rich condensates triggers recruitment of the ATG9A lipid transfer complex to initiate basal autophagy.

Autor: Broadbent DG; Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI, USA.; College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.; Department of Physiology, College of Natural Sciences, Michigan State University, East Lansing, MI, USA., McEwan CM; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA., Tsang TM; Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI, USA.; College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.; Department of Physiology, College of Natural Sciences, Michigan State University, East Lansing, MI, USA.; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.; Department of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, MI, USA.; Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Poole DM; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA., Naylor BC; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA., Price JC; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA., Schmidt JC; Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, MI, USA., Andersen JL; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.; Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 29. Date of Electronic Publication: 2023 Nov 29.

Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation.

Autor: Broadbent DG; Institute for Quantitative Health Science and Engineering, Michigan State University , East Lansing, MI, USA.; College of Osteopathic Medicine, Michigan State University , East Lansing, MI, USA.; Department of Physiology, Michigan State University, East Lansing, MI, USA., Barnaba C; Institute for Quantitative Health Science and Engineering, Michigan State University , East Lansing, MI, USA., Perez GI; Institute for Quantitative Health Science and Engineering, Michigan State University , East Lansing, MI, USA., Schmidt JC; Institute for Quantitative Health Science and Engineering, Michigan State University , East Lansing, MI, USA.; Department of Obstetrics and Gynecology, Michigan State University, East Lansing, MI, USA.

Publikováno v: The Journal of cell biology [J Cell Biol] 2023 Jul 03; Vol. 222 (7). Date of Electronic Publication: 2023 Apr 28.

Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9.

Autor: Weerasekara VK; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA., Panek DJ; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA., Broadbent DG; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA., Mortenson JB; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA., Mathis AD; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA., Logan GN; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA., Prince JT; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA., Thomson DM; Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah, USA., Thompson JW; Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, USA., Andersen JL; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA jandersen@chem.byu.edu.

Publikováno v: Molecular and cellular biology [Mol Cell Biol] 2014 Dec; Vol. 34 (24), pp. 4379-88. Date of Electronic Publication: 2014 Sep 29.