Evaluation of the neuroprotective efficacy of the gramine derivative ITH12657 against NMDA-induced excitotoxicity in the rat retina

Autor: Johnny Di Pierdomenico, Alejandro Gallego-Ortega, María Norte-Muñoz, Beatriz Vidal-Villegas, Isaac Bravo, María Boluda-Ruiz, Jose Manuel Bernal-Garro, Iván Fernandez-Bueno, Jose Carlos Pastor-Jimeno, María Paz Villegas-Pérez, Marcelino Avilés-Trigueros, Cristobal de los Ríos, Manuel Vidal-Sanz

Publikováno v: Frontiers in Neuroanatomy, Vol 18 (2024)

PurposeThe aim of this study was to investigate, the neuroprotective effects of a new Gramine derivative named: ITH12657, in a model of retinal excitotoxicity induced by intravitreal injection of NMDA.MethodsAdult Sprague Dawley rats received an intr

Externí odkaz: https://doaj.org/article/e6efdf246d1f4f608e8f4701b382fe5d

Melanopsin+RGCs Are Fully Resistant to NMDA-Induced Excitotoxicity

Autor: Beatriz Vidal-Villegas, María Paz Villegas-Pérez, Manuel Vidal-Sanz, Arturo Ortín-Martínez, Nicolás Cuenca Navarro, Jose Manuel Bernal-Garro, Juan A Miralles de Imperial-Ollero, Francisco M. Nadal-Nicolás, Johnny Di Pierdomenico

Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 12
International Journal of Molecular Sciences, Vol 20, Iss 12, p 3012 (2019)
RUA. Repositorio Institucional de la Universidad de Alicante
Universidad de Alicante (UA)

We studied short- and long-term effects of intravitreal injection of N-methyl-d-aspartate (NMDA) on melanopsin-containing (m+) and non-melanopsin-containing (Brn3a+) retinal ganglion cells (RGCs). In adult SD-rats, the left eye received a single intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2803540d86d488286184a9886b8b81

Melanopsin ⁺ RGCs Are fully Resistant to NMDA-Induced Excitotoxicity.

Autor: Vidal-Villegas B; Department of Ophthalmology, University of Murcia and Instituto Murciano de Investigación Biosanitaria (IMIB)-Virgen de la Arrixaca, 30120 Murcia, Spain. beatrizvidalvillegas@gmail.com., Di Pierdomenico J; Department of Ophthalmology, University of Murcia and Instituto Murciano de Investigación Biosanitaria (IMIB)-Virgen de la Arrixaca, 30120 Murcia, Spain. johnnydp@um.es., Miralles de Imperial-Ollero JA; Department of Ophthalmology, University of Murcia and Instituto Murciano de Investigación Biosanitaria (IMIB)-Virgen de la Arrixaca, 30120 Murcia, Spain. juanantonio.miralles@um.es., Ortín-Martínez A; Department of Ophthalmology, University of Murcia and Instituto Murciano de Investigación Biosanitaria (IMIB)-Virgen de la Arrixaca, 30120 Murcia, Spain. Arturo.OrtinMartinez@uhnresearch.ca., Nadal-Nicolás FM; Department of Ophthalmology, University of Murcia and Instituto Murciano de Investigación Biosanitaria (IMIB)-Virgen de la Arrixaca, 30120 Murcia, Spain. fm.nadalnicolas@um.es., Bernal-Garro JM; Department of Ophthalmology, University of Murcia and Instituto Murciano de Investigación Biosanitaria (IMIB)-Virgen de la Arrixaca, 30120 Murcia, Spain. jmbg@um.es., Cuenca Navarro N; Department of Physiology, Genetics and Microbiology and Multidisciplinary Institute for Environmental Studies 'Ramón Margalef', University of Alicante, 03690 Alicante, Spain. cuenca@ua.es., Villegas-Pérez MP; Department of Ophthalmology, University of Murcia and Instituto Murciano de Investigación Biosanitaria (IMIB)-Virgen de la Arrixaca, 30120 Murcia, Spain. mpville@um.es., Vidal-Sanz M; Department of Ophthalmology, University of Murcia and Instituto Murciano de Investigación Biosanitaria (IMIB)-Virgen de la Arrixaca, 30120 Murcia, Spain. manuel.vidal@um.es.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2019 Jun 20; Vol. 20 (12). Date of Electronic Publication: 2019 Jun 20.