Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Brivanib alaninate"'
Autor:
Masoumeh Sadeghi
Publikováno v:
BioImpacts : BI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ccad68af88f62d7da6843b668783fa
https://doi.org/10.15171/bi.2018.s1
https://doi.org/10.15171/bi.2018.s1
Autor:
Liren Li, Xingang Yao, Wenyu Wu, Shuwen Liu, Jiawen Zhang, Xiaoguang Chen, Yuanda Wan, Yihong Wan
Publikováno v:
Pharmacological Research. 170:105721
Dengue virus (DENV) is the most prevalent arthropod-borne viral disease of humans and has a major impact on global public health. There is no clinically approved drugs for DENV infection. Since intracellular VEGFR2 is increased in DENV infected patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b03a1fa5d2df0e9868c39537a48f4f
https://doi.org/10.1016/j.phrs.2021.105721
https://doi.org/10.1016/j.phrs.2021.105721
Publikováno v:
Journal of Pharmaceutical Sciences. 106:224-233
Application of in-line real-time process monitoring using a process analytical technology for granule size distribution can enable quality-by-design development of a drug product and enable attribute-based monitoring and control strategies. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3afcded57880011d0e69ffe6f0ca3a
https://doi.org/10.1016/j.xphs.2016.08.025
https://doi.org/10.1016/j.xphs.2016.08.025
Publikováno v:
Medicine
Rationale: Hepatocellular carcinoma (HCC) is one of the most frequent causes of cancer-related death worldwide. Its poor prognosis is due to the high invasiveness of the disease and limited efficacy of available treatments. Patient concerns: We repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266575011574fe686ee42b5a4810aeef
https://doi.org/10.1097/md.0000000000014823
https://doi.org/10.1097/md.0000000000014823
Publikováno v:
Expert Opinion on Investigational Drugs. 24:1307-1320
The era of molecular-targeted agents, particularly bevacizumab and cetuximab, has revolutionized the treatment paradigm for metastatic colorectal cancer (mCRC). Amongst the multikinase inhibitors (MKIs) examined, regorafenib was the first to establis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf9013339bf7b003c23fee61960f5bc
https://doi.org/10.1517/13543784.2015.1070483
https://doi.org/10.1517/13543784.2015.1070483
Autor:
Sherif Badawy, Ajit S. Narang, Valery Sheverev, Dilbir S. Bindra, Kevin Macias, Preetanshu Pandey, Varia Sailesh Amilal, Avi Wolf, Tim Stevens, Vadim Stepaniuk
Publikováno v:
Journal of Pharmaceutical Sciences. 104:1019-1034
Real-time monitoring and control of high shear wet granulation (HSWG) using process analytical technologies is crucial to process design, scale-up, and reproducible manufacture. Although significant progress has been made in real-time measurement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6868979d7e5d00163d21ad1704eae5
https://doi.org/10.1002/jps.24233
https://doi.org/10.1002/jps.24233
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Steve S. Y. Wang, Paul C. Lobben, Jale Muslehiddinoglu, Laporte Thomas L, Lori Spangler, Steven H. Chan, Mourad Hamedi
Publikováno v:
Organic Process Research & Development. 18:1492-1502
A thermal runaway potential was identified for the conversion of a tertiary alcohol to a hydroxypyrrolotriazine intermediate in the synthesis of brivanib alaninate. A continuous process was developed to mitigate the potential thermal runaway and allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::296fe59b7156729816ad4e8e10d9a060
https://doi.org/10.1021/op500176z
https://doi.org/10.1021/op500176z
Quality by design development of brivanib alaninate tablets: Degradant and moisture control strategy
Autor:
Ganeshkumar A. Subramanian, Judy Lin, Ajit S. Narang, Gokhale Madhushree Yeshwant, Sherif Badawy, Keirnan R. LaMarche, Vishwas V. Nesarikar, Sachin Desai
Publikováno v:
International Journal of Pharmaceutics. 469:111-120
A quality by design approach was applied to the development of brivanib alaninate tablets. Brivanib alaninate, an ester pro-drug, undergoes hydrolysis to its parent compound, BMS-540215. The shelf-life of the tablets is determined by the rate of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b59f3b310fd09ecd806176a985e55a9
https://doi.org/10.1016/j.ijpharm.2014.04.059
https://doi.org/10.1016/j.ijpharm.2014.04.059
Autor:
Daniel Wasser, Zhongmin Xu, Robert Wethman, Alan Braem, John M. Wasylyk, Shih-Ying Chang, Fernando Quiroz, David K. Leahy, James S. Bergum, Nathaniel Kopp, Paul C. Lobben, Jale Muslehiddinoglu, Laporte Thomas L, Dimitri Skliar, Evan Barlow, Frank Gibson, Lori Spangler, Chiajen Lai, Sushil K. Srivastava
Publikováno v:
Organic Process Research & Development. 19:900-907
This manuscript describes the control strategy for the commercial process to manufacture brivanib alaninate. The active pharmaceutical ingredient is a prodrug which is susceptible to hydrolysis. In addition to controlling hydrolysis, a robust strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80ca7ba371a88f12f41ba7f1fa8ce8fe
https://doi.org/10.1021/op500126u
https://doi.org/10.1021/op500126u