Zobrazeno 1 - 10
of 440
pro vyhledávání: '"Britton WJ"'
Autor:
Tran, W, Kusay, AS, Hawkins, PME, Cheung, C-Y, Nagalingam, G, Pujari, V, Ford, DJ, Stoye, A, Ochoa, JL, Audette, RE, Hortle, E, Oehlers, SH, Charman, SA, Linington, RG, Rubin, EJ, Dowson, CG, Roper, DI, Crick, DC, Balle, T, Cook, GM, Britton, WJ, Payne, RJ
Herein, we report the design and synthesis of inhibitors of Mycobacterium tuberculosis (Mtb) phospho-MurNAc-pentapeptide translocase I (MurX), the first membrane-associated step of peptidoglycan synthesis, leveraging the privileged structure of the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::f5c24932b73e26570e21341238ceeda8
https://hdl.handle.net/10453/154606
https://hdl.handle.net/10453/154606
Macrophages display marked plasticity with functions in both inflammation and tissue repair. Evidence demonstrates that this spectrum of macrophage phenotypes is influenced by their local microenvironment and tissue origin. However, in vitro macropha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::640841daf84626c0e76a9eb6b702c77f
https://hdl.handle.net/10453/152922
https://hdl.handle.net/10453/152922
Autor:
Johansen, MD, Shalini, Kumar, S, Raynaud, C, Quan, DH, Britton, WJ, Hansbro, PM, Kumar, V, Kremer, L
Tuberculosis remains a leading cause of mortality among infectious diseases worldwide, prompting the need to discover new drugs to fight this disease. We report herein, the design, synthesis and anti-mycobacterial activity of isatin-mono/bis-isoniazi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::47a8a50352d27b7cad3b8c8dbb9af7b0
https://hdl.handle.net/10453/149759
https://hdl.handle.net/10453/149759
Autor:
Ho, J, Bokil, NJ, Nguyen, PTB, Nguyen, TA, Liu, MY, Hare, N, Fox, GJ, Saunders, BM, Marks, GB, Britton, WJ
OBJECTIVES:Global tuberculosis (TB) control is restricted by the failure to detect an estimated 3.3 million TB cases annually. In the majority of TB endemic settings, sputum smear microscopy is used to diagnose TB, but this test is insensitive for TB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::6a9e18d33153af2baee5c550bec8e81d
https://hdl.handle.net/10453/142161
https://hdl.handle.net/10453/142161
Autor:
Hansell, AL, Bakolis, I, Cowie, CT, Belousova, EG, Ng, K, Weber-Chrysochoou, C, Britton, WJ, Leeder, S, Tovey, E, Webb, K, Toelle, B, Marks, GB
Publikováno v:
Environmental Health, Vol 17, Iss 1, Pp 1-11 (2018)
Background Studies of potential adverse effects of traffic related air pollution (TRAP) on allergic disease have had mixed findings. Nutritional studies to examine whether fish oil supplementation may protect against development of allergic disease t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::61de24206d0d3c1e621e1b5b61ddb22d
http://link.springer.com/article/10.1186/s12940-018-0370-5
http://link.springer.com/article/10.1186/s12940-018-0370-5
Copyright © 2017 by The American Association of Immunologists, Inc. Damaging inflammation is a hallmark of Mycobacterium tuberculosis infection, and understanding how this is regulated is important for the development of new therapies to limit exces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::dba474866f3e7b69e81262b5a9c1d4eb
https://hdl.handle.net/10453/125161
https://hdl.handle.net/10453/125161
© 2016 American Chemical Society. Tuberculosis (TB) remains a prevalent and lethal infectious disease. The glycobiology associated with Mycobacterium tuberculosis infection of frontline alveolar macrophages is still unresolved. Herein, we investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::c415bf6a941402047aca2abb9e389204
https://hdl.handle.net/10453/124935
https://hdl.handle.net/10453/124935
Autor:
Britton WJ (AUTHOR), Lockwood DNJ (AUTHOR)
Publikováno v:
Lancet. 4/10/2004, Vol. 363 Issue 9416, p1209-1219. 11p.
Autor:
Walters, SB, Kieckbusch, J, Nagalingam, G, Swain, A, Latham, SL, Grau, GER, Britton, WJ, Combes, V, Saunders, BM
Mycobacterium tuberculosis infection is characterized by a strong inflammatory response whereby a few infected macrophages within the granuloma induce sustained cellular accumulation. The mechanisms coordinating this response are poorly characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::23735e9fa6665f34543df08d0c1d3895
https://hdl.handle.net/10453/116221
https://hdl.handle.net/10453/116221
Publikováno v:
Leprosy review. 66(3)
Many leprosy patients treated with multidrug therapy (MDT) had previously received dapsone (DDS) monotherapy for many years. We report here 2 such patients treated with modified paucibacillary MDT composed of rifampicin and DDS who subsequently relap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d4f5cbf2affc7a0a5f0f0d62b5659f
https://pubmed.ncbi.nlm.nih.gov/7500815
https://pubmed.ncbi.nlm.nih.gov/7500815