The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior

Autor: Prarthana Shankar, Gloria R Garcia, Jane K La Du, Christopher M Sullivan, Cheryl L Dunham, Britton C Goodale, Katrina M Waters, Stanislau Stanisheuski, Claudia S Maier, Preethi Thunga, David M Reif, Robyn L Tanguay

Publikováno v: Toxicol Sci

The aryl hydrocarbon receptor (AHR) is required for vertebrate development and is also activated by exogenous chemicals, including polycyclic aromatic hydrocarbons (PAHs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). AHR activation is well-understo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca4427ca8a9658b5e08a8000cbc6f81
https://europepmc.org/articles/PMC9308396/

Monomethylarsonous Acid (MMAIII) Has an Adverse Effect on the Innate Immune Response of Human Bronchial Epithelial Cells to Pseudomonas aeruginosa.

Autor: Emily G Notch, Britton C Goodale, Roxanna Barnaby, Bonita Coutermarsh, Brent Berwin, Vivien F Taylor, Brian P Jackson, Bruce A Stanton

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0142392 (2015)

Arsenic is the number one contaminant of concern with regard to human health according to the World Health Organization. Epidemiological studies on Asian and South American populations have linked arsenic exposure with an increased incidence of lung

Externí odkaz: https://doaj.org/article/8ed1600c299b42958253dc4f024f16e8

Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells

Autor: Britton C. Goodale, Erica J. Rayack, Bruce A. Stanton

Publikováno v: Toxicology and Applied Pharmacology. 331:154-163

Arsenic contamination of drinking water and food threatens the health of hundreds of millions of people worldwide by increasing the risk of numerous diseases. Arsenic exposure has been associated with infectious lung disease in epidemiological studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31ba82b77a0196181b44e9cd8b6a039
https://doi.org/10.1016/j.taap.2017.06.010

Opportunities and Challenges for Dietary Arsenic Intervention

Autor: Keeve E. Nachman, Kathryn L. Cottingham, Margaret R. Karagas, Claire Pendergrast, Erik J. Tokar, Margaret Kurzius-Spencer, Kenneth J. Reimer, Thomas A. Burke, Mark D. Miller, Carolyn J. Murray, Habibul Ahsan, Celia Y. Chen, Tanja Schwerdtle, Britton C. Goodale, Andrea Raab, Kirk G. Scheckel, Laurie R. Rardin, Vivien F. Taylor, Brian P. Jackson, Todd M. Warczak, Mary Lou Guerinot, Gary L. Ginsberg, Tracy Punshon, Maria Argos, Andrew A. Meharg, Antonio J. Signes-Pastor, Anne E. Nigra, Francesco Cubadda

Publikováno v: Nachman, K E, Punshon, T, Rardin, L, Signes-Pastor, A J, Murray, C J, Jackson, B P, Guerinot, M L, Burke, T A, Chen, C Y, Ahsan, H, Argos, M, Cottingham, K L, Cubadda, F, Ginsberg, G L, Goodale, B C, Kurzius-Spencer, M, Meharg, A A, Miller, M D, Nigra, A E, Pendergrast, C B, Raab, A, Reimer, K, Scheckel, K G, Schwerdtle, T, Taylor, V F, Tokar, E J, Warczak, T M & Karagas, M R 2018, ' Opportunities and Challenges for Dietary Arsenic Intervention ' Environmental Health Perspectives, vol. 126, no. 8, pp. 84503 . DOI: 10.1289/EHP3997
Environmental Health Perspectives

Summary: The diet is emerging as the dominant source of arsenic exposure for most of the U.S. population. Despite this, limited regulatory efforts have been aimed at mitigating exposure, and the role of diet in arsenic exposure and disease processes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5606890625e965782e1b9aea29adea6b
https://pure.qub.ac.uk/portal/en/publications/opportunities-and-challenges-for-dietary-arsenic-intervention(a52fcdb7-79c4-4e5c-b552-9aba2b7fbd30).html

Ligand-Specific Transcriptional Mechanisms Underlie Aryl Hydrocarbon Receptor-Mediated Developmental Toxicity of Oxygenated PAHs

Autor: Robert L. Tanguay, Susan C. Tilton, Katrina M. Waters, C. M. Sullivan, William H. Bisson, J. La Du, Britton C. Goodale

Publikováno v: Toxicological Sciences. 147:397-411

Polycyclic aromatic hydrocarbons (PAHs) are priority environmental contaminants that exhibit mutagenic, carcinogenic, proinflammatory, and teratogenic properties. Oxygen-substituted PAHs (OPAHs) are formed during combustion processes and via phototox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4327257f7ca9bf116a0cbabca579ea32
https://doi.org/10.1093/toxsci/kfv139