Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Brittney S, Bates"'
Autor:
Walter J. Chazin, Carrie F. Browning, Edward T. Olejniczak, J.D. Patrone, Bhavatarini Vangamudi, Alex G. Waterson, Stephen W. Fesik, Benjamin A. Gilston, Elaine M. Souza-Fagundes, DeMarco V. Camper, Michael D. Feldkamp, Olivia W. Rossanese, Andreas O. Frank, N.F. Pelz, Brittney S. Bates, Alexey G. Kuznetsov
Publikováno v:
ChemMedChem. 11:893-899
Replication protein A (RPA) is an essential single-stranded DNA (ssDNA)-binding protein that initiates the DNA damage response pathway through protein-protein interactions (PPIs) mediated by its 70N domain. The identification and use of chemical prob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b943ba901b0b67263224cce5f311d58
https://doi.org/10.1002/cmdc.201500479
https://doi.org/10.1002/cmdc.201500479
Autor:
Andrew S. Felts, Daryl F. Venable, Frank W. Byers, Analisa D. Thompson Gray, P. Jeffrey Conn, Carrie K. Jones, Brittney S. Bates, Mohammed N. Tantawy, Jerri M. Rook, Craig W. Lindsley, Colleen M. Niswender, Kyle A. Emmitte, Gilles Tamagnan, Vincent B. Luscombe, Anna L. Blobaum, J. Scott Daniels, Alice L. Rodriguez, Sichen Chang, Ryan D. Morrison
Publikováno v:
Journal of Medicinal Chemistry
Preclinical evidence in support of the potential utility of mGlu5 NAMs for the treatment of a variety of psychiatric and neurodegenerative disorders is extensive, and multiple such molecules have entered clinical trials. Despite some promising result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9bf4ee93e41f4306aff0746cd2d2f7
https://pubmed.ncbi.nlm.nih.gov/28530802
https://pubmed.ncbi.nlm.nih.gov/28530802
Autor:
P. Jeffrey Conn, Daryl F. Venable, Anna L. Blobaum, Jason Manka, Frank W. Byers, J. Scott Daniels, Colleen M. Niswender, Brittney S. Bates, Andrew S. Felts, Kyle A. Emmitte, Craig W. Lindsley, Alice L. Rodriguez, Carrie K. Jones, Ryan D. Morrison
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5779-5785
Development of SAR in an aryl ether series of mGlu5 NAMs leading to the identification of tool compound VU0409106 is described in this Letter. VU0409106 is a potent and selective negative allosteric modulator of mGlu5 that binds at the known alloster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9f7ffe0817814bcc13ec2e65816675
https://doi.org/10.1016/j.bmcl.2013.09.001
https://doi.org/10.1016/j.bmcl.2013.09.001
Autor:
Cynthia B. Berry, Leah C. Konkol, Leslie N. Aldrich, Miranda So, Craig W. Lindsley, Brittney S. Bates
Publikováno v:
European Journal of Organic Chemistry. 2013:4215-4218
Herein, we describe the enantioselective construction of the 12-membered macrocyclic pyrrole core 4 of marineosin A in 5.1% overall yield from (S)-propylene oxide. The route features a key Stetter reaction to install a 1,4-diketone, which is then sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53d666dc783a4f37200a133330538d51
https://doi.org/10.1002/ejoc.201300643
https://doi.org/10.1002/ejoc.201300643
Autor:
Colleen M. Niswender, Kyle A. Emmitte, Karen J. Gregory, Andrew S. Felts, Danny G. Winder, Jens Meiler, Christopher M. Olsen, Alice L. Rodriguez, Jeffrey P. Lamb, Craig W. Lindsley, Usha N. Menon, Ralf Mueller, Brittney S. Bates, Eric S. Dawson, Carrie K. Jones, P. Jeffrey Conn, Alexander S. Kane, Brian A. Chauder, Sataywan B. Jadhav
Publikováno v:
ChemMedChem. 7:406-414
Glutamate, the major excitatory neurotransmitter, functions in the brain via activation of ligand gated cation channels and also the eight subtypes of Class C G protein-coupled metabotropic glutamate receptors (mGlus).[1] Selective allosteric modulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f05778db6ec355ffe22f60073c5ab46b
https://doi.org/10.1002/cmdc.201100510
https://doi.org/10.1002/cmdc.201100510
Autor:
Brittney S. Bates, Shaun R. Stauffer, P. Jeffrey Conn, Hilary Highfield Nickols, Joannes P. Yuh, Analisa D. Thompson, Xiaohui Lv, Craig W. Lindsley, J. Scott Daniels, Zixiu Xiang, Colleen M. Niswender, Karen J. Gregory, Kyle A. Emmitte, Michael Bubser, Carrie K. Jones, Ryan D. Morrison, Michael T. Nedelcovych, Weimin Peng
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 356(1)
Negative allosteric modulators (NAMs) of metabotropic glutamate receptor subtype 5 (mGlu5) have potential applications in the treatment of fragile X syndrome, levodopa-induced dyskinesia in Parkinson disease, Alzheimer disease, addiction, and anxiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107a350a8d4d53c2d21070e3265abcb1
https://pubmed.ncbi.nlm.nih.gov/26503377
https://pubmed.ncbi.nlm.nih.gov/26503377
Autor:
Brittney S. Bates, Alice L. Rodriguez, Andrew S. Felts, Ryan D. Morrison, Daryl F. Venable, Anna L. Blobaum, Frank W. Byers, Kera P. Lawson, J. Scott Daniels, Colleen M. Niswender, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte
Development of SAR in an aryl ether series of mGlu5 NAMs leading to the identification of pyrazine analog VU0431316 is described in this Letter. VU0431316 is a potent and selective non-competitive antagonist of mGlu5 that binds at a known allosteric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dff112798da1a00da0573ce8f25e829
https://europepmc.org/articles/PMC4090943/
https://europepmc.org/articles/PMC4090943/
Autor:
Leslie N, Aldrich, Cynthia B, Berry, Brittney S, Bates, Leah C, Konkol, Miranda, So, Craig W, Lindsley
Publikováno v:
European journal of organic chemistry. 2013(20)
Herein, we describe the enantioselective construction of the 12-membered macrocyclic pyrrole core 4 of marineosin A in 5.1% overall yield from (S)-propylene oxide. The route features a key Stetter reaction to install a 1,4-diketone, which is then sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9465dd8a9150889f707fe047644acb40
https://pubmed.ncbi.nlm.nih.gov/24415906
https://pubmed.ncbi.nlm.nih.gov/24415906
Autor:
Cynthia B. Berry, Joseph D. Panarese, Craig W. Lindsley, Leslie N. Aldrich, Leah C. Konkol, Brittney S. Bates
Publikováno v:
Tetrahedron letters. 54(18)
In this Letter, we describe a short, six step enantioselective route to spiroaminal lactam model systems reminiscent of marineosins A and B that has been developed starting from either ( R )- or ( S )-hydroxysuccinic acid, respectively, in ∼9% over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7709900a1acbcc95d305ae41d7a8cd2b
https://pubmed.ncbi.nlm.nih.gov/23606772
https://pubmed.ncbi.nlm.nih.gov/23606772
Autor:
Donald F. Stec, Alice L. Rodriguez, Ryan D. Morrison, Anna L. Blobaum, Roger Rush, Daryl F. Venable, Katrina A. Brewer, Andrew S. Felts, Thomas M. Bridges, P. Jeffrey Conn, Kyle A. Emmitte, Craig W. Lindsley, Melany M. Corlew, Colleen M. Niswender, Tammy S. Santomango, Frank W. Byers, J. Scott Daniels, Raymundo Sanchez-Ponce, Carrie K. Jones, Brittney S. Bates, Jason Manka
Negative allosteric modulation (NAM) of metabotropic glutamate receptor subtype 5 (mGlu5) represents a therapeutic strategy for the treatment of childhood developmental disorders, such as fragile X syndrome and autism. VU0409106 emerged as a lead com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0389e68c022ccf3e9d93be7fbdaf65
https://europepmc.org/articles/PMC3422546/
https://europepmc.org/articles/PMC3422546/