Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Brittney J, Mills"'
Autor:
Preeti G, Desai, Patrick, Garidel, Francisca O, Gbormittah, Douglas E, Kamen, Brittney J, Mills, Chakravarthy N, Narasimhan, Shubhadra, Singh, Elaine S E, Stokes, Erika R, Walsh
Publikováno v:
Journal of Pharmaceutical Sciences. 112:359-369
Developing high-dose biologic drugs for subcutaneous injection often requires high-concentration formulations and optimizing viscosity, solubility, and stability while overcoming analytical, manufacturing, and administration challenges. To understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2723942fc9795493b62e3ab0c13db841
https://doi.org/10.1016/j.xphs.2022.11.020
https://doi.org/10.1016/j.xphs.2022.11.020
Publikováno v:
Journal of Pharmaceutical Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2446e3212582f522bbf09794489cd45
https://doi.org/10.1016/j.xphs.2023.03.021
https://doi.org/10.1016/j.xphs.2023.03.021
Publikováno v:
Journal of Pharmaceutical Sciences. 109:1662-1672
The physical stability of antibody drug conjugates is dictated by the properties of the antibody, linker-drug, and conjugation site. Two linker-drugs were chosen that are different in terms of hydrophobicity and polar surface area to evaluate the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c446b92919de55abf2578a14be12e91
https://doi.org/10.1016/j.xphs.2020.01.029
https://doi.org/10.1016/j.xphs.2020.01.029
Autor:
Shubhadra N. Singh, George Crotts, Tanvir Tabish, Qingyan Hu, Brittney J. Mills, Lori S. Burton, Douglas E. Kamen, Hodge Tamara Shafer, Yongmei Wu, Francisca O. Gbormittah, Sonal Saluja, Elaine S.E. Stokes, Kevin Muthurania, Adithi C. Bhargava, Chakravarthy Nachu Narasimhan, Ligi Mathews
Publikováno v:
Journal of pharmaceutical sciences. 111(4)
In-use stability and compatibility studies are often used in biotherapeutic development to assess stability and compatibility of biologic drugs with diluents and/or administration components at relevant conditions for the target route of administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df8538532608b92255c19f48603c61c
https://pubmed.ncbi.nlm.nih.gov/34600941
https://pubmed.ncbi.nlm.nih.gov/34600941
Publikováno v:
Development of Biopharmaceutical Drug-Device Products ISBN: 9783030314149
Rapid innovation of antibody-based modalities to treat different diseases, such as oncology, immuno-oncology, and chronic inflammation, and the speed with which these modalities are progressing through discovery is requiring the acceleration of produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5796f1417a02ef8c32b2aa01234746c2
https://doi.org/10.1007/978-3-030-31415-6_12
https://doi.org/10.1007/978-3-030-31415-6_12
Autor:
Anthony R. Haight, Tony Cano, Brittney J. Mills, Vikram Sisodiya, Feroz Jameel, Ehab M. Moussa
Publikováno v:
Development of Biopharmaceutical Drug-Device Products ISBN: 9783030314149
Antibody-drug conjugates (ADCs) have emerged as a new class of anti-cancer drugs where the strengths of cytotoxic small molecules are combined with specificity/selectivity of antibodies to enhance the therapeutic efficacy and safety of the drug. All
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bd2d164ae8f701c19cc3450f80c8eb2
https://doi.org/10.1007/978-3-030-31415-6_2
https://doi.org/10.1007/978-3-030-31415-6_2
Publikováno v:
Development of Biopharmaceutical Drug-Device Products ISBN: 9783030314149
Freeze-drying is a commonly used manufacturing operation for biopharmaceuticals to enhance the storage stability. The stability of the product during freeze-drying and upon storage depends on the design of the formulation and the freeze-drying proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c1c1f52c125727e9a57aebd38002ab1
https://doi.org/10.1007/978-3-030-31415-6_21
https://doi.org/10.1007/978-3-030-31415-6_21
Publikováno v:
Development of Biopharmaceutical Drug-Device Products ISBN: 9783030314149
Because of their marginal stability in the liquid state, biologic solutions are stored and shipped frozen to enhance stability and operational flexibility for further processing. During the freezing process, protein solutions can undergo denaturation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c12c1e1c9ba619c150c767b70b5c6b1
https://doi.org/10.1007/978-3-030-31415-6_19
https://doi.org/10.1007/978-3-030-31415-6_19
Publikováno v:
Development of Biopharmaceutical Drug-Device Products ISBN: 9783030314149
Monoclonal antibodies (mAbs) are the largest class of therapeutic proteins. Owing to their versatile structure and function, mAbs are used for a wide range of therapeutic indications including oncology, immunology, neurology, metabolic, and cardiovas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e61d5c6592a4518db70fe974384bb4d3
https://doi.org/10.1007/978-3-030-31415-6_1
https://doi.org/10.1007/978-3-030-31415-6_1
Autor:
Brittney J. Mills, Samantha E. Pace, David D. Weis, Reza Esfandiary, David B. Volkin, C. Russell Middaugh, Ronald T. Toth, Sangeeta B. Joshi
Publikováno v:
Journal of Pharmaceutical Sciences. 107:1009-1019
Antibodies are molecules that exhibit diverse conformational changes on different timescales, and there is ongoing interest to better understand the relationship between antibody conformational dynamics and storage stability. Physical stability data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951be3f3caf27c3149f06ce21d414bd6
https://doi.org/10.1016/j.xphs.2017.12.009
https://doi.org/10.1016/j.xphs.2017.12.009