Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Brittany-Lee Roberts"'
1
Akademický článek
Hsp40s specify functions of Hsp104 and Hsp90 protein chaperone machines.
Autor: Michael Reidy, Ruchika Sharma, Shankar Shastry, Brittany-Lee Roberts, Ivan Albino-Flores, Sue Wickner, Daniel C Masison
Publikováno v: PLoS Genetics, Vol 10, Iss 10, p e1004720 (2014)
Hsp100 family chaperones of microorganisms and plants cooperate with the Hsp70/Hsp40/NEF system to resolubilize and reactivate stress-denatured proteins. In yeast this machinery also promotes propagation of prions by fragmenting prion polymers. We pr
Externí odkaz: https://doaj.org/article/38c7950798dd4fd59052b654cb8d7156
Zobrazit plný text záznamu
2
Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis
Autor: Keith Crosby, P. John Hart, Brittany-Lee Roberts, Jacob I. Ayers, Hilda Brown, David R. Borchelt, Anthony M. Crown
Publikováno v: G3: Genes, Genomes, Genetics, Vol 9, Iss 3, Pp 719-728 (2019)
G3: Genes|Genomes|Genetics
Mutations in more than 80 different positions in superoxide dismutase 1 (SOD1) have been associated with amyotrophic lateral sclerosis (fALS). There is substantial evidence that a common consequence of these mutations is to induce the protein to misf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9d97be3e3780f1dbd849ac235ae4a5
http://g3journal.org/lookup/doi/10.1534/g3.118.200787
Zobrazit plný text záznamu
5
Molecular dynamics simulations of Hsp40 J-domain mutants identifies disruption of the critical HPD-motif as the key factor for impaired curing in vivo of the yeast prion [URE3]
Autor: Gary W. Jones, Brittany-Lee Roberts, Hao Wang, You-Lin Xue, Michael Riedy, Youtao Song, Daniel C. Masison, Yuna Sun, Yong-Bo Song
Genetic screens using Saccharomyces cerevisiae have identified an array of Hsp40 (Ydj1p) J-domain mutants that are impaired in the ability to cure the yeast [URE3] prion through disrupting functional interactions with Hsp70. However, biochemical anal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406b2a96e6247517c936a0f5e6fb2113
https://europepmc.org/articles/PMC6312664/
Zobrazit plný text záznamu
7
Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models
Autor: Brittany-Lee Roberts, Anthony M. Crown, David R. Borchelt, Keith Crosby, Hilda Brown, Jacob I. Ayers
Publikováno v: PLoS ONE, Vol 13, Iss 11, p e0206751 (2018)
PLoS ONE
Mutations in superoxide dismutase 1 (SOD1) associated with familial amyotrophic lateral sclerosis (fALS) induce the protein to misfold and aggregate. Missense mutations at more than 80 different amino acid positions have been associated with disease.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8994af4f0118b55f15fbd73221f75640
https://doi.org/10.1371/journal.pone.0206751
Zobrazit plný text záznamu
8
Human J-protein DnaJB6b Cures a Subset of Saccharomyces cerevisiae Prions and Selectively Blocks Assembly of Structurally Related Amyloids
Autor: Ruchika Sharma, Daniel C. Masison, Brittany-Lee Roberts, Michael Reidy
Publikováno v: The Journal of biological chemistry. 291(8)
Human chaperone DnaJB6, an Hsp70 co-chaperone whose defects cause myopathies, protects cells from polyglutamine toxicity and prevents purified polyglutamine and Aβ peptides from forming amyloid. Yeast prions [URE3] and [PSI(+)] propagate as amyloid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb0904e836e558e2dd6ba99444199d2
https://pubmed.ncbi.nlm.nih.gov/26702057
Zobrazit plný text záznamu
9
Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice
Autor: Hilda Brown, David R. Borchelt, Susan Fromholt, Cameron Green, Brittany-Lee Roberts, Guilian Xu, Jacob I. Ayers
Co-expression of wild-type human superoxide dismutase 1 (WT-hSOD1) with ALS mutant hSOD1 accelerates disease onset relative to mice expressing only mutant protein. Here, we analyzed the effect of co-expressed WT-hSOD1 in two established mutant mouse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25790d927029f03f6f72971f4fcc400a
https://europepmc.org/articles/PMC4375410/
Zobrazit plný text záznamu
10
Hsp40s specify functions of Hsp104 and Hsp90 protein chaperone machines
Autor: Shankar Shastry, Michael Reidy, Ivan Albino-Flores, Sue Wickner, Brittany-Lee Roberts, Ruchika Sharma, Daniel C. Masison
Publikováno v: PLoS Genetics, Vol 10, Iss 10, p e1004720 (2014)
PLoS Genetics
Hsp100 family chaperones of microorganisms and plants cooperate with the Hsp70/Hsp40/NEF system to resolubilize and reactivate stress-denatured proteins. In yeast this machinery also promotes propagation of prions by fragmenting prion polymers. We pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce6b1d56560463ba739f9b3e012bd77
http://europepmc.org/articles/PMC4199505?pdf=render
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje