Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Brittany Seibert"'
Autor:
Flavio Cargnin Faccin, C. Joaquin Cáceres, L. Claire Gay, Brittany Seibert, Nick van Bentem, Luis A. Rodriguez, Ana Luiza Soares Fraiha, Matias Cardenas, Ginger Geiger, Lucia Ortiz, Silvia Carnaccini, Darrell R. Kapczynski, Daniela S. Rajao, Daniel R. Perez
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-15 (2024)
Abstract Avian influenza poses a severe threat to poultry production and global food security, prompting the development of vaccination programs in numerous countries. Modified live virus (MLV) vaccines, with their potential for mass application, off
Externí odkaz:
https://doaj.org/article/8ee0c4117ca04530bd8b5350ac5ed468
Autor:
Stivalis Cardenas-Garcia, C. Joaquín Cáceres, Aarti Jain, Ginger Geiger, Jong-Suk Mo, L. Claire Gay, Brittany Seibert, Algimantas Jasinskas, Rie Nakajima, Daniela S. Rajao, D. Huw Davies, Daniel R. Perez
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-15 (2024)
Abstract Influenza B virus (FLUBV) poses a significant infectious threat, with frequent vaccine mismatch limiting its effectiveness. Our previous work investigated the safety and efficacy of modified live attenuated FLUBV vaccines with rearranged gen
Externí odkaz:
https://doaj.org/article/5cf2b41fc1b64520a18a1305c32a4e4a
Autor:
Santosh Dhakal, Han-Sol Park, Kumba Seddu, John S. Lee, Patrick S. Creisher, Brittany Seibert, Kimberly M. Davis, Isabella R. Hernandez, Robert W. Maul, Sabra L. Klein
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTAdult females of reproductive age develop greater antibody responses to inactivated influenza vaccines (IIV) than males. How sex, age, and sex steroid concentrations impact B cells and durability of IIV-induced immunity and protection over 4
Externí odkaz:
https://doaj.org/article/9901ea5c319d48a3b41a8ad6886cf06d
Autor:
Matias Cardenas, Brittany Seibert, Brianna Cowan, Ana Luiza S Fraiha, Silvia Carnaccini, L Claire Gay, Flavio Cargnin Faccin, C Joaquin Caceres, Tavis K Anderson, Amy L Vincent Baker, Daniel R Perez, Daniela S Rajao
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1012026 (2024)
Influenza A virus (FLUAV) infects a wide range of hosts and human-to-swine spillover events are frequently reported. However, only a few of these human viruses have become established in pigs and the host barriers and molecular mechanisms driving ada
Externí odkaz:
https://doaj.org/article/3943ce80e7994e41ae46ef44be037427
Autor:
Ketaki Ganti, Anish Bagga, Silvia Carnaccini, Lucas M. Ferreri, Ginger Geiger, C. Joaquin Caceres, Brittany Seibert, Yonghai Li, Liping Wang, Taeyong Kwon, Yuhao Li, Igor Morozov, Wenjun Ma, Juergen A. Richt, Daniel R. Perez, Katia Koelle, Anice C. Lowen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Virus reassortment drives genetic diversity and evolution and is governed by intra-host dynamics that are less well understood. Here, the authors characterise the within-host dynamics of influenza A virus reassortment in swine, ferrets and guinea pig
Externí odkaz:
https://doaj.org/article/2a977b93d93f4addbfde5d614e81fd52
Autor:
C. Joaquin Caceres, Brittany Seibert, Flavio Cargnin Faccin, Stivalis Cardenas‐Garcia, Daniela S. Rajao, Daniel R. Perez
Publikováno v:
FEBS Open Bio, Vol 12, Iss 6, Pp 1142-1165 (2022)
Influenza A and B viruses are among the most prominent human respiratory pathogens. About 3–5 million severe cases of influenza are associated with 300 000–650 000 deaths per year globally. Antivirals effective at reducing morbidity and mortality
Externí odkaz:
https://doaj.org/article/d220d3b164764f989544ab119169bf73
Autor:
Brittany Seibert, C Joaquín Cáceres, Silvia Carnaccini, Stivalis Cardenas-Garcia, L Claire Gay, Lucia Ortiz, Ginger Geiger, Daniela S Rajao, Elizabeth Ottesen, Daniel R Perez
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010734 (2022)
The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS2) affected the geriatric population. Among research models, Golden Syrian hamsters (GSH) are one of the most representative to study SARS2 pathogenesis and host responses. However,
Externí odkaz:
https://doaj.org/article/cfad1eb2b2374650a1d9974870e1d958
Autor:
C. Joaquín Cáceres, Stivalis Cardenas-Garcia, Silvia Carnaccini, Brittany Seibert, Daniela S. Rajao, Jun Wang, Daniel R. Perez
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the defining global health emergency of this century. GC-376 is a Mpro inhibitor with antiviral activity against SARS-CoV-2 in vitro. Using t
Externí odkaz:
https://doaj.org/article/71d2e993765649be8e0f6b0bf79c99a9
Autor:
Brittany Seibert, C. Joaquín Cáceres, Stivalis Cardenas-Garcia, Silvia Carnaccini, Ginger Geiger, Daniela S. Rajao, Elizabeth Ottesen, Daniel R. Perez
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 1 (2021)
ABSTRACT Transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in millions of deaths and declining economies around the world. K18-hACE2 mice develop disease resembling severe SARS-CoV-2 infection in a virus do
Externí odkaz:
https://doaj.org/article/6ee130111ef0476ba74dc520cf6d7798
Autor:
C. Joaquín Cáceres, Stivalis Cardenas-Garcia, Aarti Jain, L. Claire Gay, Silvia Carnaccini, Brittany Seibert, Lucas M. Ferreri, Ginger Geiger, Algimantas Jasinskas, Rie Nakajima, Daniela S. Rajao, Irina Isakova-Sivak, Larisa Rudenko, Amy L. Vincent, D. Huw Davies, Daniel R. Perez
Publikováno v:
Vaccines, Vol 9, Iss 7, p 703 (2021)
Live attenuated influenza virus (LAIV) vaccines elicit a combination of systemic and mucosal immunity by mimicking a natural infection. To further enhance protective mucosal responses, we incorporated the gene encoding the IgA-inducing protein (IGIP)
Externí odkaz:
https://doaj.org/article/4b6e3593a646491a831a12edd5b1380f