Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Brittany P. Fenner"'
Autor:
Brittany P. Fenner, D. B. Darden, Lauren S. Kelly, Jaimar Rincon, Scott C. Brakenridge, Shawn D. Larson, Frederick A. Moore, Philip A. Efron, Lyle L. Moldawer
Publikováno v:
Frontiers in Medicine, Vol 7 (2021)
Improved management of severe sepsis has been one of the major health care accomplishments of the last two decades. Due to enhanced recognition and improved management of severe sepsis, in-hospital mortality has been reduced by up to 40%. With that g
Externí odkaz:
https://doaj.org/article/5065c164310a4e0299a849c7d6a63ae6
Autor:
Hari K. Parvataneni, Alicia M. Mohr, Brittany P Fenner, Camille G Apple, Scott C. Brakenridge, Jennifer E. Hagen, Lauren S Kelly, Erick E Pons, Kolenkode B. Kannan, Philip A. Efron, Dijoia B Darden
Publikováno v:
Shock
Background Severe trauma is associated with severe systemic inflammation and neuroendocrine activation that is associated with erythroid progenitor growth suppression and refractory anemia. Although distinct transcriptional profiles have been detecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f22d335ec8fb8546826508d23ec654
https://doi.org/10.1097/shk.0000000000001826
https://doi.org/10.1097/shk.0000000000001826
Autor:
Dijoia B. Darden, Scott C. Brakenridge, Philip A. Efron, Gabriela L. Ghita, Brittany P. Fenner, Lauren S. Kelly, Babette Brumback, Alicia M. Mohr, Lyle L. Moldawer, Frederick A. Moore
Publikováno v:
Ann Surg
Objective To analyze serial biomarkers of the persistent inflammation, immunosuppression, and catabolism syndrome (PICS) to gain insight into the pathobiology of chronic critical illness (CCI) after surgical sepsis. Background Although early deaths a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c361fcaa32f40c99b71a657d26a944ee
https://pubmed.ncbi.nlm.nih.gov/34506322
https://pubmed.ncbi.nlm.nih.gov/34506322
Autor:
Marie Gauthier, Lyle L. Moldawer, Alicia M. Mohr, Xiaoru Dong, Azra Bihorac, Frederick A. Moore, Todd M. Brusko, Rhonda Bacher, Lauren S Kelly, Dina C. Nacionales, Tyler J. Loftus, Philip A. Efron, Ricardo Ungaro, Dijoia B Darden, Michael P. Kladde, Marvin L. Dirain, Jaimar Rincon, Maigan A. Brusko, Brittany P Fenner
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
BackgroundWith the successful implementation of the Surviving Sepsis Campaign guidelines, post-sepsis in-hospital mortality to sepsis continues to decrease. Those who acutely survive surgical sepsis will either rapidly recover or develop a chronic cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b04e1718e2cc519689134642ae455d
https://doi.org/10.3389/fimmu.2021.696536
https://doi.org/10.3389/fimmu.2021.696536
Autor:
Philip A. Efron, Henry V. Baker, Tezcan Ozrazgat-Baslanti, Lyle L. Moldawer, Maria-Cecilia Lopez, Rhonda Bacher, Tyler J. Loftus, Alicia M. Mohr, Michael C. Cox, Scott C. Brakenridge, Dijoia B Darden, Gabriela L. Ghita, Azra Bihorac, Christiaan Leeuwenburgh, Frederick A. Moore, Jaimar Rincon, Zhongkai Wang, Russell B. Hawkins, Lauren S Kelly, Brittany P Fenner, Julie A. Stortz
Publikováno v:
Journal of Clinical Medicine
Volume 10
Issue 15
Journal of Clinical Medicine, Vol 10, Iss 3211, p 3211 (2021)
Volume 10
Issue 15
Journal of Clinical Medicine, Vol 10, Iss 3211, p 3211 (2021)
Surgical sepsis has evolved into two major subpopulations: patients who rapidly recover, and those who develop chronic critical illness (CCI). Our primary aim was to determine whether CCI sepsis survivors manifest unique blood leukocyte transcriptome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced522aca935be2ab5aa9b51908244b5
Autor:
Maria-Cecilia Lopez, Scott C. Brakenridge, Lyle L. Moldawer, Ashrita Budharaju, Brittany P Fenner, Tyler J. Loftus, Philip A. Efron, Dijoia B Darden, Juan C. Mira, Julie A. Stortz, Dina C. Nacionales, Alicia M. Mohr, Frederick A. Moore, Henry V. Baker, Lauren S Kelly
Publikováno v:
J Trauma Acute Care Surg
BACKGROUND After severe trauma, the older host experiences more dysfunctional hematopoiesis of bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs), and dysfunctional differentiation of circulating myeloid cells into effective innate immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c110c688ee4fd436c9fe9f0c04cdcff9
https://pubmed.ncbi.nlm.nih.gov/34252063
https://pubmed.ncbi.nlm.nih.gov/34252063
Autor:
Dijoia B Darden, Philip A. Efron, Brittany P Fenner, Lyle L. Moldawer, Gabriella Ghita, Timothy E. Sweeney, Oliver Liesenfeld, Uros Midic, Scott C. Brakenridge, James Wacker, Petr Starostik
PurposePrognostic metrics for the rapid and accurate prediction of sepsis severity that could elicit a meaningful change in clinical practice are currently lacking. Here, we evaluated a whole blood, multiplex host mRNA expression metric, Inflammatix-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10ec08104783b85db17c00e60cfac92e
https://doi.org/10.1101/2021.05.28.21258014
https://doi.org/10.1101/2021.05.28.21258014
Autor:
Dijoia B Darden, Lauren S Kelly, Alicia M. Mohr, Brittany P Fenner, Philip A. Efron, Lyle L. Moldawer
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 1742, p 1742 (2021)
Journal of Clinical Medicine
Journal of Clinical Medicine
Implementation of protocolized surveillance, diagnosis, and management of septic patients, and of surgical sepsis patients in particular, is shown to result in significantly increased numbers of patients surviving their initial hospitalization. Curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666fdd1d95384db3ed503fb1796f29c7
https://www.mdpi.com/2077-0383/10/8/1742
https://www.mdpi.com/2077-0383/10/8/1742
Publikováno v:
Shock
Hematopoietic stem/progenitor cells (HSPC) have both unique and common responses following hemorrhage, injury, and sepsis. HSPCs from different lineages have a distinctive response to these "stress" signals. Inflammation, via the production of inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7069c38cbc4cc530b49df08959355265
https://pubmed.ncbi.nlm.nih.gov/33234838
https://pubmed.ncbi.nlm.nih.gov/33234838
Autor:
Shawn D. Larson, Frederick A. Moore, Lauren S Kelly, Philip A. Efron, Lyle L. Moldawer, Jaimar Rincon, Brittany P Fenner, Dijoia B Darden, Scott C. Brakenridge
Publikováno v:
Frontiers in Medicine
Frontiers in Medicine, Vol 7 (2021)
Frontiers in Medicine, Vol 7 (2021)
Improved management of severe sepsis has been one of the major health care accomplishments of the last two decades. Due to enhanced recognition and improved management of severe sepsis, in-hospital mortality has been reduced by up to 40%. With that g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe12bb2bb749a6bfd741cca50a34c32a
https://pubmed.ncbi.nlm.nih.gov/33659259
https://pubmed.ncbi.nlm.nih.gov/33659259