Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells

Autor: Fabio R. Santori, Gregor Lorbek, Pengxiang Huang, Rok Keber, Alain Rahier, Brittany N. Rosales, W. David Nes, Simon Horvat, Damjana Rozman, Serge A. van de Pavert, David J. Leaver, Brad A. Haubrich, Dan R. Littman, Eugene F. Douglass, Fraydoon Rastinejad, Reina E. Mebius, Tanja Konijn

Publikováno v: Santori, F R, Huang, P X, van de Pavert, S A, Douglass, E F, Leaver, D J, Haubrich, B A, Keber, R, Lorbek, G, Konijn, T, Rosales, B N, Rozman, D, Horvat, S, Rahier, A, Mebius, R E, Rastinejad, F, Nes, W D & Littman, D R 2015, ' Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells ', Cell Metabolism, vol. 21, no. 2, pp. 286-297 . https://doi.org/10.1016/j.cmet.2015.01.004
Cell Metabolism, 21(2), 286-297. Cell Press

Mice deficient in the nuclear hormone receptor RORγt have defective development of thymocytes, lymphoid organs, Th17 cells, and type 3 innate lymphoid cells. RORγt binds to oxysterols derived from cholesterol catabolism, but it is not clear whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9954ffd3b62b7c6a9ee55d203f9cea
https://doi.org/10.1016/j.cmet.2015.01.004