Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Brittany N, Dugger"'
Autor:
Rebeca Scalco, Luca C. Oliveira, Zhengfeng Lai, Danielle J. Harvey, Lana Abujamil, Charles DeCarli, Lee-Way Jin, Chen-Nee Chuah, Brittany N. Dugger
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Accurate and scalable quantification of amyloid-β (Aβ) pathology is crucial for deeper disease phenotyping and furthering research in Alzheimer Disease (AD). This multidisciplinary study addresses the current limitations on neuropathology
Externí odkaz:
https://doaj.org/article/db05312ca87d4aeab039bcdcaa3089b8
Autor:
Hsin-Pei Wang, Rebeca Scalco, Naomi Saito, Laurel Beckett, My-Le Nguyen, Emily Z. Huie, Lawrence S. Honig, Charles DeCarli, Robert A. Rissman, Andrew F. Teich, Dan M. Mungas, Lee-Way Jin, Brittany N. Dugger
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-12 (2024)
Abstract Cerebrovascular and α-synuclein pathologies are frequently observed alongside Alzheimer disease (AD). The heterogeneity of AD necessitates comprehensive approaches to postmortem studies, including the representation of historically underrep
Externí odkaz:
https://doaj.org/article/2ccca9693bd8481a91ee168a49211a38
Autor:
Juan C. Vizcarra, Thomas M. Pearce, Brittany N. Dugger, Michael J. Keiser, Marla Gearing, John F. Crary, Evan J. Kiely, Meaghan Morris, Bartholomew White, Jonathan D. Glass, Kurt Farrell, David A. Gutman
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract Machine learning (ML) has increasingly been used to assist and expand current practices in neuropathology. However, generating large imaging datasets with quality labels is challenging in fields which demand high levels of expertise. Further
Externí odkaz:
https://doaj.org/article/b2678bd5981b4644b024934250897893
Autor:
Amparo Villablanca, Brittany N. Dugger, Saivageethi Nuthikattu, Joohi Chauhan, Samson Cheung, Chen-Nee Chuah, Siedah L. Garrison, Dragan Milenkovic, Jennifer E. Norman, Luca Cerny Oliveira, Bridgette P. Smith, Susan D. Brown
Publikováno v:
Journal of Clinical and Translational Science, Vol 8 (2024)
Cardiovascular disease (CVD) is largely preventable, and the leading cause of death for men and women. Though women have increased life expectancy compared to men, there are marked sex disparities in prevalence and risk of CVD-associated mortality an
Externí odkaz:
https://doaj.org/article/3509363ecb65400493c8f6ce85a8647d
A statistics textbook that delivers essential data analysis techniques for Alzheimer's and other neurodegenerative diseases.Alzheimer's disease is a devastating condition that presents overwhelming challenges to patients and caregivers. In the face o
Autor:
Daniel R. Wong, Shino D. Magaki, Harry V. Vinters, William H. Yong, Edwin S. Monuki, Christopher K. Williams, Alessandra C. Martini, Charles DeCarli, Chris Khacherian, John P. Graff, Brittany N. Dugger, Michael J. Keiser
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-9 (2023)
Abstract Precise, scalable, and quantitative evaluation of whole slide images is crucial in neuropathology. We release a deep learning model for rapid object detection and precise information on the identification, locality, and counts of cored plaqu
Externí odkaz:
https://doaj.org/article/c3d3f3daf1b44aed967015946cc7eb2d
Autor:
Rebeca Scalco, Naomi Saito, Laurel Beckett, My-Le Nguyen, Emily Huie, Hsin-Pei Wang, Delaney A. Flaherty, Lawrence S. Honig, Charles DeCarli, Robert A. Rissman, Andrew F. Teich, Lee-Way Jin, Brittany N. Dugger
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Despite the increasing demographic diversity of the United States’ aging population, there remain significant gaps in post-mortem research investigating the ethnoracial heterogeneity in the neuropathological landscape of Alzheimer Disease
Externí odkaz:
https://doaj.org/article/c400d7d0dfbe4c4d88b0540088c7067d
Autor:
Daniel R. Wong, Ziqi Tang, Nicholas C. Mew, Sakshi Das, Justin Athey, Kirsty E. McAleese, Julia K. Kofler, Margaret E. Flanagan, Ewa Borys, Charles L. White, Atul J. Butte, Brittany N. Dugger, Michael J. Keiser
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-22 (2022)
Abstract Pathologists can label pathologies differently, making it challenging to yield consistent assessments in the absence of one ground truth. To address this problem, we present a deep learning (DL) approach that draws on a cohort of experts, we
Externí odkaz:
https://doaj.org/article/e7fb3386bbae4059a6d4c1c8990efffb
Autor:
Nian Jiang, Bowen Xie, Wenwu Xiao, Ming Fan, Shanxiu Xu, Yixin Duan, Yamah Hamsafar, Angela C. Evans, Jie Huang, Weibing Zhou, Xuelei Lin, Ningrong Ye, Siyi Wanggou, Wen Chen, Di Jing, Ruben C. Fragoso, Brittany N. Dugger, Paul F. Wilson, Matthew A. Coleman, Shuli Xia, Xuejun Li, Lun-Quan Sun, Arta M. Monjazeb, Aijun Wang, William J. Murphy, Hsing-Jien Kung, Kit S. Lam, Hong-Wu Chen, Jian Jian Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Acquired radioresistance is a challenge for the cure of glioblastoma. Here, the authors show that radioresistant glioblastoma boosts mitochondrial fatty acid oxidation that fuels cell proliferation and induces immunosuppression via CD47 mediated anti
Externí odkaz:
https://doaj.org/article/9ea4ad505be945a8af46118fb26c43d3
Autor:
Zhengfeng Lai, Luca Cerny Oliveira, Runlin Guo, Wenda Xu, Zin Hu, Kelsey Mifflin, Charles Decarli, Sen-Ching Cheung, Chen-Nee Chuah, Brittany N. Dugger
Publikováno v:
IEEE Access, Vol 10, Pp 49064-49079 (2022)
As neurodegenerative disease pathological hallmarks have been reported in both grey matter (GM) and white matter (WM) with different density distributions, automating the segmentation process of GM/WM would be extremely advantageous for aiding in neu
Externí odkaz:
https://doaj.org/article/10e3127e129f4604a4c7a27894592b6d