Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Brittany Mathias"'
Autor:
Ricardo Ungaro, Lyle L. Moldawer, Shawn D. Larson, Brittany Mathias, Steven L. Raymond, Jaimar Rincon, James L. Wynn, Angela L. Cuenca, Philip A. Efron, Dina C. Nacionales
Publikováno v:
Clinical and Experimental Immunology. 191:268-278
Summary The high mortality in neonatal sepsis has been related to both quantitative and qualitative differences in host protective immunity. Pretreatment strategies to prevent sepsis have received inadequate consideration, especially in the premature
Autor:
Juan C. Mira, Jonathan P. Rehfuss, Henry V. Baker, Brittany Mathias, Ricardo Ungaro, Lyle L. Moldawer, Shawn D. Larson, Jaimar Rincon, M. Cecilia Lopez, Dina C. Nacionales
Publikováno v:
Shock. 47:606-614
The neonatal innate immune system differs to microbial infection both quantitatively and qualitatively when compared with adults. Here, we provide the first genome-wide ex-vivo expression profile of umbilical cord blood (UCB) neutrophils from full-te
Autor:
Frederick A. Moore, Alicia M. Mohr, Brittany Mathias, Lori F. Gentile, Philip A. Efron, Scott C. Brakenridge, Lyle L. Moldawer, Juan C. Mira
Publikováno v:
Critical Care Medicine. 45:253-262
Objectives:To provide an appraisal of the evolving paradigms in the pathophysiology of sepsis and propose the evolution of a new phenotype of critically ill patients, its potential underlying mechanism, and its implications for the future of sepsis m
Autor:
Ella Benninghaus, Jim Fyfe, London Fletcher, Rick Bout, Brittany Mathias, Krista Hupman, Giverny Forbes, Ingrid N. Visser, Alexander A. Grabham, Tracy E. Cooper, Daniel A Godoy, Martin Cawthorn, Kimberly Matucci
In contrast to previous reports that leopard seals (Hydrurga leptonyx) are rare vagrants to New Zealand, we show that this species is a regular member of the marine fauna of this region. We present a first analysis from the New Zealand Leopard Seal D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce6f457d8c5f0cdd0369395e8fef885
Publikováno v:
Current Opinion in Pediatrics. 28:380-387
Sepsis is the leading cause of pediatric death worldwide. In the United States alone, there are 72 000 children hospitalized for sepsis annually with a reported mortality rate of 25% and an economic cost estimated to be $4.8 billion. However, it is o
Autor:
Maria-Cecilia Lopez, Juan C. Mira, Henry V. Baker, Frederick A. Moore, Brittany Mathias, Martin D. Rosenthal, Ricardo Ungaro, Alicia M. Mohr, Benjamin E. Szpila, Lyle L. Moldawer, Dina C. Nacionales, Shawn D. Larson, David Holden, Patrick T. Verdugo, Scott C. Brakenridge, Erin Vanzant, Lori F. Gentile, Philip A. Efron, Jaimar Rincon
Publikováno v:
Physiological Genomics. 48:135-144
Controversy remains whether the leukocyte genomic response to trauma or sepsis is dependent upon the initiating stimulus. Previous work illustrated poor correlations between historical models of murine trauma and sepsis (i.e., trauma-hemorrhage and l
Publikováno v:
Surgery. 159:371-374
'Big data' is the next frontier of medicine. We now have the ability to generate and analyze large quantities of healthcare data. Although interpreting and integrating this information into clinical practice poses many challenges, the potential benef
Autor:
Alicia M. Mohr, Lyle L. Moldawer, Tyler J. Loftus, Brittany Mathias, Ricardo Ungaro, Juan C. Mira, Philip A. Efron, Dina C. Nacionales
Publikováno v:
Methods in Molecular Biology ISBN: 9781493975242
Severe injury and shock remain major sources of morbidity and mortality worldwide. Immunologic dysregulation following trauma contributes to these poor outcomes. Few, if any, therapeutic interventions have benefited these patients, and this is due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad39849c2fb663a3b055a717be0849d
https://doi.org/10.1007/978-1-4939-7526-6_1
https://doi.org/10.1007/978-1-4939-7526-6_1
Autor:
Alicia M. Mohr, Lizette Vila Duckworth, Brittany Mathias, Donevan Westerveld, Benjamin E. Szpila, Lyle L. Moldawer, Jianyi Zhang, Anna Maria Joseph, Frederick A. Moore, Ricardo Ungaro, Lori F. Gentile, Henry V. Baker, Azra Bihorac, Erin Vanzant, Dina C. Nacionales, M. Cecilia Lopez, Scott C. Brakenridge, Jeevan Jyot, Philip A. Efron, Christiaan Leeuwenburgh, Angela L. Cuenca
Publikováno v:
The Journal of Immunology. 195:2396-2407
The elderly are particularly susceptible to trauma, and their outcomes are frequently dismal. Such patients often have complicated clinical courses and ultimately die of infection and sepsis. Recent research has revealed that although elderly subject
Autor:
Brittany Mathias, Tezcan Ozrazgat-Baslanti, Alicia M. Mohr, Benjamin E. Szpila, Lyle L. Moldawer, Frederick A. Moore, Babette Brumback, Amber L. Delmas, Scott C. Brakenridge, Erin Vanzant, Philip A. Efron
We hypothesized that after sepsis in humans, MDSCs will be persistently increased, functionally immunosuppressive, and associated with adverse clinical outcomes.Cancer and sepsis have surprisingly similar immunologic responses and equally dismal long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a084337a9f6d848c5074e1cff15feb
https://europepmc.org/articles/PMC5102824/
https://europepmc.org/articles/PMC5102824/