Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Brittany M. Edens"'
Publikováno v:
Cell Reports, Vol 20, Iss 5, Pp 1148-1160 (2017)
Summary: Cells initiate fate decisions during G1 phase by converting extracellular signals into distinctive cell cycle kinetics. The DNA replication timing is determined in G1 phase; lengthened G1 and hastened S phases correlate with increased neurog
Externí odkaz:
https://doaj.org/article/908f655f4f6b43999ef652ff2fb57733
Publikováno v:
eLife, Vol 6 (2017)
The etiological underpinnings of amyotrophic lateral sclerosis (ALS) are complex and incompletely understood, although contributions to pathogenesis by regulators of proteolytic pathways have become increasingly apparent. Here, we present a novel var
Externí odkaz:
https://doaj.org/article/d56a80c9cd784894b56a22723e6abfe1
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
Selective motor neuron degeneration is a hallmark of amyotrophic lateral sclerosis (ALS). Around 10 percent of all cases present as familial ALS (FALS), while sporadic ALS (SALS) accounts for the remaining 90 percent. Diverse genetic mutations leadin
Externí odkaz:
https://doaj.org/article/8efddb32c9394f159f331cb250133c21
Autor:
Hailing Shi, Nimrod Miller, Allen Zhu, Yong Chao Ma, Zhike Lu, Brittany M. Edens, Chuan He, Phillip J. Hsu
Publikováno v:
Journal of Biological Chemistry. 294:19889-19895
N6-Methyladenosine (m6A) is the most abundant post-transcriptional mRNA modification in eukaryotes and exerts many of its effects on gene expression through reader proteins that bind specifically to m6A-containing transcripts. Fragile X mental retard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::965219dfb88e415208153c7091fb3bcd
https://doi.org/10.1074/jbc.ac119.010078
https://doi.org/10.1074/jbc.ac119.010078
Publikováno v:
Cell Reports, Vol 20, Iss 5, Pp 1148-1160 (2017)
Summary: Cells initiate fate decisions during G1 phase by converting extracellular signals into distinctive cell cycle kinetics. The DNA replication timing is determined in G1 phase; lengthened G1 and hastened S phases correlate with increased neurog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c03024209c4de02b69bccc9ed8ea306
https://doi.org/10.1016/j.celrep.2017.07.018
https://doi.org/10.1016/j.celrep.2017.07.018
Autor:
Phillip J, Hsu, Hailing, Shi, Allen C, Zhu, Zhike, Lu, Nimrod, Miller, Brittany M, Edens, Yongchao C, Ma, Chuan, He
Publikováno v:
J Biol Chem
N(6)-Methyladenosine (m(6)A) is the most abundant post-transcriptional mRNA modification in eukaryotes and exerts many of its effects on gene expression through reader proteins that bind specifically to m(6)A-containing transcripts. Fragile X mental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b80779121f355ddb982853ad0ca6b5e2
https://pubmed.ncbi.nlm.nih.gov/31753916
https://pubmed.ncbi.nlm.nih.gov/31753916
Autor:
Brittany M, Edens, Caroline, Vissers, Jing, Su, Saravanan, Arumugam, Zhaofa, Xu, Han, Shi, Nimrod, Miller, Francisca, Rojas Ringeling, Guo-Li, Ming, Chuan, He, Hongjun, Song, Yongchao C, Ma
Publikováno v:
Cell reports
SUMMARY N6-methyladenosine (m6A) modification of mRNA is emerging as a vital mechanism regulating RNA function. Here, we show that fragile X mental retardation protein (FMRP) reads m6A to promote nuclear export of methylated mRNA targets during neura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37998ba9411992fe02068322f72c1c25
https://pubmed.ncbi.nlm.nih.gov/31340148
https://pubmed.ncbi.nlm.nih.gov/31340148
Autor:
Zhihua Feng, Chien-Ping Ko, Thomas O. Crawford, Charlotte J. Sumner, Brittany M. Edens, Benjamin Taige Hong, Jorge A. Cantu, Christie C. Sze, Susan C. Su, Yong Chao Ma, Ben Yang, Jacek Topczewski, Long Ma, Nimrod Miller, Han Shi
Publikováno v:
The Journal of Neuroscience. 35:6038-6050
Mechanisms underlying motor neuron degeneration in spinal muscular atrophy (SMA), the leading inherited cause of infant mortality, remain largely unknown. Many studies have established the importance of hyperphosphorylation of the microtubule-associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e27737bba2dcaf09c4a034807ae550
https://doi.org/10.1523/jneurosci.3716-14.2015
https://doi.org/10.1523/jneurosci.3716-14.2015
Publikováno v:
eLife, Vol 6 (2017)
Amyotrophic lateral sclerosis, or ALS for short, is a disease in which parts of the brain and spinal cord progressively degenerate. Specifically, the condition causes the nerve cells that control movement – called motor neurons – to die. As a res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b9e5d70a576d766d3693323481d32e
https://elifesciences.org/articles/25453
https://elifesciences.org/articles/25453
