Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Brittany M Flowers"'
Autor:
Brittany M Flowers, Lauren E Rusnak, Kristen E Wong, Dallas A Banks, Michelle R Munyikwa, Alexander G McFarland, Shantá D Hinton
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114535 (2014)
The rat pheochromocytoma PC12 cell line is a widely used system to study neuronal differentiation for which sustained activation of the extracellular signaling related kinase (ERK) pathway is required. Here, we investigate the function of MK-STYX [MA
Externí odkaz:
https://doaj.org/article/ba3c8cb713f74b99a1b0f799251d2bf7
Autor:
Bo He, Lauren Stoffel, Clifford Jiajun He, Kumsun Cho, Albert M. Li, Haowen Jiang, Brittany M. Flowers, Kha The Nguyen, Kelly Wen Wang, Audrey Yixin Zhao, Meng-Ning Zhou, Sofia Ferreira, Laura D. Attardi, Jiangbin Ye
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract As a highly heterogeneous tumor, pancreatic ductal adenocarcinoma (PDAC) exhibits non-uniform responses to therapies across subtypes. Overcoming therapeutic resistance stemming from this heterogeneity remains a significant challenge. Here, w
Externí odkaz:
https://doaj.org/article/49624cfd032446e1b3b7c7e99edf32b1
Autor:
Jonghyeob Lee, Emily R. Snyder, Yinghua Liu, Xueying Gu, Jing Wang, Brittany M. Flowers, Yoo Jung Kim, Sangbin Park, Gregory L. Szot, Ralph H. Hruban, Teri A. Longacre, Seung K. Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Models of human pancreatic intraepithelial neoplasia (PanIN) development do not exist. Here, the authors induce oncogenicKRAS and mutations in CDKN2A, SMAD4 and TP53in primary human pancreatic cells to generate a PanIN model that recapitulates molecu
Externí odkaz:
https://doaj.org/article/07f5f64889bc4267b1acdb73c8a62eac
Autor:
Laura D. Attardi, Laura D. Wood, Christina Curtis, Hannes Vogel, Jose A. Seoane, Kathryn J. Hanson, Abigail S. Mulligan, Hang Xu, Brittany M. Flowers
Phenotypes in acinar cell-of-origin Trp53 missense mutation mouse cohorts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e7a0300163ef7dcb4ed680150ef27a
https://doi.org/10.1158/2159-8290.22535615.v1
https://doi.org/10.1158/2159-8290.22535615.v1
Autor:
Laura D. Attardi, Laura D. Wood, Christina Curtis, Hannes Vogel, Jose A. Seoane, Kathryn J. Hanson, Abigail S. Mulligan, Hang Xu, Brittany M. Flowers
Analysis of pancreatic cancer development from adult mouse acinar cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47384cef5a60110a12ea502d242095eb
https://doi.org/10.1158/2159-8290.22535636.v1
https://doi.org/10.1158/2159-8290.22535636.v1
Autor:
Laura D. Attardi, Laura D. Wood, Christina Curtis, Hannes Vogel, Jose A. Seoane, Kathryn J. Hanson, Abigail S. Mulligan, Hang Xu, Brittany M. Flowers
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a 5-year survival rate of approximately 9%. An improved understanding of PDAC initiation and progression is paramount for discovering strategies to better detect and combat this disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::825fa4fdbfd40e5cef224b7a0989a598
https://doi.org/10.1158/2159-8290.c.6547895.v1
https://doi.org/10.1158/2159-8290.c.6547895.v1
Autor:
Stephano S. Mello, Brittany M. Flowers, Pawel K. Mazur, James J. Lee, Fabian Müller, Sarah K. Denny, Sofia Ferreira, Kathryn Hanson, Seung K. Kim, William J. Greenleaf, Laura D. Wood, Laura D. Attardi
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The vast majority of human pancreatic ductal adenocarcinomas (PDACs) harbor TP53 mutations, underscoring p53’s critical role in PDAC suppression. PDAC can arise when pancreatic acinar cells undergo acinar-to-ductal metaplasia (ADM), giving rise to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5817b2938e07f8a64a650278c9904b0
https://doi.org/10.1073/pnas.2211937120
https://doi.org/10.1073/pnas.2211937120
Autor:
Dallas A. Banks, Arya Dahal, Alexander G. McFarland, Brittany M. Flowers, Christina A. Stephens, Benjamin Swack, Ayele Gugssa, Winston A. Anderson, Shantá D. Hinton
Publikováno v:
Frontiers in Molecular Biosciences, Vol 4 (2017)
We previously reported that the pseudophosphatase MK-STYX (mitogen activated kinase phosphoserine/threonine/tyrosine binding protein) dramatically increases the number of what appeared to be primary neurites in rat pheochromocytoma (PC-12) cells; how
Externí odkaz:
https://doaj.org/article/4f568161ef8e48908ad74ab8714a2fbe
Autor:
Bo He, Lauren Stoffel, Clifford Jiajun He, Albert Mao Li, Haowen Jiang, Kumsun Cho, Brittany M. Flowers, Sofia Ferreira, Laura D. Attardi, Jiangbin Ye
Publikováno v:
Cancer Research. 83:3905-3905
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, which is largely due to the intrinsic resistance to a broad spectrum of therapies. Vitamin D (VD) has been extensively studied as a potential preventive or therapeutic agent for PDAC tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::377fe30cb63f9da6acd9177c7b00c2f7
https://doi.org/10.1158/1538-7445.am2023-3905
https://doi.org/10.1158/1538-7445.am2023-3905
Autor:
Brittany M. Flowers, Kathryn Hanson, Abigail S. Mulligan, Christina Curtis, Laura D. Attardi, Hannes Vogel, Laura D. Wood, Jose A. Seoane, Hang Xu
Publikováno v:
Cancer Discov
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a 5-year survival rate of approximately 9%. An improved understanding of PDAC initiation and progression is paramount for discovering strategies to better detect and combat this disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6933c9d0f8d3ee4c1948490fdf00b5
https://doi.org/10.1158/2159-8290.cd-20-0633
https://doi.org/10.1158/2159-8290.cd-20-0633