Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Brittany M Anderson-Steele"'
Autor:
JohnPatrick Rogers, Jonathan Ashby, Jongchan Yeo, Brittany M Anderson-Steele, Sheila S. David, Sheng Cao
Publikováno v:
ACS Chem Biol
ACS chemical biology, vol 15, iss 4
ACS chemical biology, vol 15, iss 4
The guanine oxidation products, 5-guanidinohydantoin (Gh) and spiroiminodihydantoin (Sp), are mutagenic and toxic base lesions that are removed by Fpg, Nei, and the Nei-like (NEIL) glycosylases as the first step in base excision repair (BER). The hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c4482c22d49fed3c28a1907b48bce0
https://doi.org/10.1021/acschembio.9b00923
https://doi.org/10.1021/acschembio.9b00923
Publikováno v:
Biochemistry
Biochemistry, vol 60, iss 19
Biochemistry, vol 60, iss 19
Editing of the pre-mRNA of the DNA repair glycosylase NEIL1 results in substitution of a Lys with Arg in the lesion recognition loop of the enzyme. Unedited (UE, Lys242) NEIL1 removes thymine glycol lesions in DNA ∼30 times faster than edited (Ed,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b52a07b38820cb92436c8653f5454df
https://pubmed.ncbi.nlm.nih.gov/33929180
https://pubmed.ncbi.nlm.nih.gov/33929180