Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Brittany Larson"'
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Supplementary Tables 1 and 2 from Mechanisms Promoting Escape from Mitotic Stress–Induced Tumor Cell Death
Autor: Angelique W. Whitehurst, Kathryn M. Cappell, Patrick Taus, Daniela Mytsa, Brittany Larson, Leah Winters, Rebecca Sinnott
XLSX - 4269K, Supplementary Table 1 lists viability scores from the pan-genomic siRNA screen. Supplementary Table 2 lists the high interest chemosensitizers and indicates those siRNA pools selected for secondary screening analysis.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28865fbb2cd9611846d69ddcd6e2aecd
https://doi.org/10.1158/0008-5472.22400105
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2
Supplementary Materials and Methods, Supplementary Figure Legends, and Supplementary Figures 1 through 5 from Mechanisms Promoting Escape from Mitotic Stress–Induced Tumor Cell Death
Autor: Angelique W. Whitehurst, Kathryn M. Cappell, Patrick Taus, Daniela Mytsa, Brittany Larson, Leah Winters, Rebecca Sinnott
PDF - 195K, Supplementary figure 1 displays micronucleation of paclitaxel resistant NSCLC cells, fate mapping of micronucleated HCC366 cells, and the scheme and full data set results from the pan-genomic screen. Supplementary figure 2 provides raw da
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193be06cdf673f17210f89a4c4489cba
https://doi.org/10.1158/0008-5472.22400108
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4
Data from Mechanisms Promoting Escape from Mitotic Stress–Induced Tumor Cell Death
Autor: Angelique W. Whitehurst, Kathryn M. Cappell, Patrick Taus, Daniela Mytsa, Brittany Larson, Leah Winters, Rebecca Sinnott
Non–small cell lung cancer (NSCLC) is notorious for its paltry responses to first-line therapeutic regimens. In contrast to acquired chemoresistance, little is known about the molecular underpinnings of the intrinsic resistance of chemo-naïve NSCL
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc9cfda972fa5058b0adec0adc99ba26
https://doi.org/10.1158/0008-5472.c.6505499
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5
Recombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma
Autor: Brittany Larson, Gary G. Koch, Alisa S. Wolberg, Kellie R. Machlus, Robert A. Campbell, Laura D. Gray, Michael A. Hussey, Ulla Hedner, Mirella Ezban
Publikováno v: Thrombosis Research. 128:570-576
The bypassing agent recombinant factor VIIa (rFVIIa) is efficacious in treating bleeding in hemophilia patients with inhibitors. Efforts have focused on the rational engineering of rFVIIa variants with increased hemostatic potential. One rFVIIa analo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d42794ec79383b55f0ee8e38cf57b1
https://doi.org/10.1016/j.thromres.2011.04.009
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6
Symplekin Specifies Mitotic Fidelity by Supporting Microtubule Dynamics
Autor: Angelique W. Whitehurst, Noah Sciaky, Kathryn M. Cappell, Brittany Larson
Publikováno v: Molecular and Cellular Biology. 30:5135-5144
Using a pangenomic loss-of-function screening strategy, we have previously identified 76 potent modulators of paclitaxel responsiveness in non-small-cell lung cancer. The top hit isolated from this screen, symplekin, is a well-established component o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6d4d3742c5e9a1302e1eabf4c73bb2
https://doi.org/10.1128/mcb.00758-10
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7
Mechanisms promoting escape from mitotic stress-induced tumor cell death
Autor: Daniela Mytsa, Kathryn M. Cappell, Leah Winters, Brittany Larson, Angelique W. Whitehurst, Rebecca Sinnott, Patrick Taus
Publikováno v: Cancer research. 74(14)
Non–small cell lung cancer (NSCLC) is notorious for its paltry responses to first-line therapeutic regimens. In contrast to acquired chemoresistance, little is known about the molecular underpinnings of the intrinsic resistance of chemo-naïve NSCL
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b5d13f06c39a52a52b659596cb7097
https://pubmed.ncbi.nlm.nih.gov/24860162
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8
Tumor antigen acrosin binding protein normalizes mitotic spindle function to promote cancer cell proliferation
Autor: John O. Schorge, Kathryn M. Cappell, Jackie Thomas Swanik, Brittany Larson, Angelique W. Whitehurst, Yang Xie, Michael A. White, S.C. Purinton, Luc Girard
Publikováno v: Cancer research. 70(19)
Cancer cells manage to divide in the context of gross chromosomal abnormalities. These abnormalities can promote bypass of normal restraints on cell proliferation but at a cost of mitotic vulnerabilities that can be attacked by chemotherapy. Determin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6223c86f637f7f6cd39220c1f0d86b
https://pubmed.ncbi.nlm.nih.gov/20876808
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9
Abstract LB-345: Functional genomics reveals acute dependencies on polyadenylation for tumor cell mitotic progression
Autor: Noah Sciaky, Kathryn M. Cappell, Angelique W. Whitehurst, Brittany Larson
Publikováno v: Cancer Research. 70:LB-345
We are using genome-wide synthetic lethal paclitaxel chemosensitizer screens to understand the protein networks that support mitosis in lung tumor cells. Using this approach, we have identified several components of the polyadenylation machinery that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::931cff950c2a21c2ffdbd530a8deaf3d
https://doi.org/10.1158/1538-7445.am10-lb-345
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