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pro vyhledávání: '"Brittany L. Ford"'
Autor:
Yu-Hua Lo, Mack Sobhany, Allen L. Hsu, Brittany L. Ford, Juno M. Krahn, Mario J. Borgnia, Robin E. Stanley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Rix7 is a type II AAA-ATPase that is required for the assembly of the large ribosomal subunit. Here the authors present the 4.5 Å cryo-EM structure of the Rix7 homohexamer with a polypeptide fragment bound in its central channel and provide insight
Externí odkaz:
https://doaj.org/article/532b14f2bbab448784ac75464a65da1f
Autor:
Brittany L Ford, Ting Wei, Hester Liu, Catherine E Scull, Saman M Najmi, Stephanie Pitts, Wenjun Fan, David A Schneider, Marikki Laiho
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285660 (2023)
RNA Polymerase I (Pol I) has recently been recognized as a cancer therapeutic target. The activity of this enzyme is essential for ribosome biogenesis and is universally activated in cancers. The enzymatic activity of this multi-subunit complex resid
Externí odkaz:
https://doaj.org/article/deb9e959af1549c0995c621a11a4bf5f