Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Brittany K. Matlock"'
Autor:
Ly Pham, Padmini Komalavilas, Alex M. Eddie, Timothy E. Thayer, Dalton L. Greenwood, Ken H. Liu, Jaclyn Weinberg, Andrew Patterson, Joshua P. Fessel, Kelli L. Boyd, Jenny C. Schafer, Jamie L. Kuck, Aaron C. Shaver, David K. Flaherty, Brittany K. Matlock, Christiaan D. M. Wijers, C. Henrique Serezani, Dean P. Jones, Evan L. Brittain, Jeffrey C. Rathmell, Michael J. Noto
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Cpt1a-dependent fatty acid beta-oxidation is found to regulate neutrophil trafficking to the site of infection in a mouse model of pneumonia and is found to play a role in pneumonia susceptibility in humans.
Externí odkaz:
https://doaj.org/article/d76a7386c54d4c2f854b839fc40b5550
Autor:
Andrew J. Siladi, Jing Wang, Andrea C. Florian, Lance R. Thomas, Joy H. Creighton, Brittany K. Matlock, David K. Flaherty, Shelly L. Lorey, Gregory C. Howard, Stephen W. Fesik, April M. Weissmiller, Qi Liu, William P. Tansey
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract WDR5 nucleates the assembly of histone-modifying complexes and acts outside this context in a range of chromatin-centric processes. WDR5 is also a prominent target for pharmacological inhibition in cancer. Small-molecule degraders of WDR5 ha
Externí odkaz:
https://doaj.org/article/4970649d70db445fb70eaa8e823937b6
Autor:
Aqeela Afzal, Eric E. Figueroa, Sujay V. Kharade, Kevin Bittman, Brittany K. Matlock, David K. Flaherty, Jerod S. Denton
Publikováno v:
Physiological Reports, Vol 7, Iss 23, Pp n/a-n/a (2019)
Abstract There has been a resurgence of interest in the volume‐regulated anion channel (VRAC) since the recent cloning of the LRRC8A‐E gene family that encodes VRAC. The channel is a heteromer comprised of LRRC8A and at least one other family mem
Externí odkaz:
https://doaj.org/article/1ed9b19f0c6b4c8cb960f91917af1c42
Autor:
Amar M. Singh, James Chappell, Robert Trost, Li Lin, Tao Wang, Jie Tang, Brittany K. Matlock, Kevin P. Weller, Hao Wu, Shaying Zhao, Peng Jin, Stephen Dalton
Publikováno v:
Stem Cell Reports, Vol 2, Iss 3, p 398 (2014)
Externí odkaz:
https://doaj.org/article/8f1df7a5321a493f873131345395b7c2
Autor:
Heini M Natri, Christina B Del Azodi, Lance Peter, Chase J Taylor, Sagrika Chugh, Robert Kendle, Mei-i Chung, David K Flaherty, Brittany K Matlock, Carla L Calvi, Timothy S Blackwell, Lorraine B Ware, Matthew Bacchetta, Rajat Walia, Ciara M Shaver, Jonathan A Kropski, Davis J McCarthy, Nicholas E Banovich
Publikováno v:
bioRxiv
Common genetic variants confer substantial risk for chronic lung diseases, including pulmonary fibrosis (PF). Defining the genetic control of gene expression in a cell-type-specific and context-dependent manner is critical for understanding the mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb33f8d2914884f147f02fc19d6ac0f
https://europepmc.org/articles/PMC10055257/
https://europepmc.org/articles/PMC10055257/
Autor:
Stephen W. Fesik, Dai H. Chung, William P. Tansey, David K. Flaherty, Alissa D. Guarnaccia, Eric J. Rellinger, April M. Weissmiller, Shelly L. Lorey, Brittany K. Matlock, Erin R. Aho, Chase M Woodley, Gregory C. Howard, Qi Liu, Audra F Bryan, Jing Wang
Publikováno v:
Nucleic Acids Research
WDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in the context of chromatin. WDR5 is also a promising target for pharmacological inhibition in cancer, with small molecule inhibitors of an arginine-binding pocke
Autor:
Andrea C Florian, Chase M Woodley, Jing Wang, Brian C Grieb, Macey J Slota, Kiana Guerrazzi, Chih-Yuan Hsu, Brittany K Matlock, David K Flaherty, Shelly L Lorey, Stephen W Fesik, Gregory C Howard, Qi Liu, April M Weissmiller, William P Tansey
Publikováno v:
NAR Cancer. 4
Rhabdoid tumors (RT) are rare and deadly pediatric cancers driven by loss of SMARCB1, which encodes the SNF5 component of the SWI/SNF chromatin remodeler. Loss of SMARCB1 is associated with a complex set of phenotypic changes including vulnerability
Autor:
Nicholas M. Negretti, Erin J. Plosa, John T. Benjamin, Bryce A. Schuler, A. Christian Habermann, Christopher S. Jetter, Peter Gulleman, Claire Bunn, Alice N. Hackett, Meaghan Ransom, Chase J. Taylor, David Nichols, Brittany K. Matlock, Susan H. Guttentag, Timothy S. Blackwell, Nicholas E. Banovich, Jonathan A. Kropski, Jennifer M. S. Sucre
Publikováno v:
Development
Lung organogenesis requires precise timing and coordination to effect spatial organization and function of the parenchymal cells. To provide a systematic broad-based view of the mechanisms governing the dynamic alterations in parenchymal cells over c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0071bc69a1fd8bc9e9d363891b2f1ac2
https://europepmc.org/articles/PMC8722390/
https://europepmc.org/articles/PMC8722390/
Autor:
Andrew J. Siladi, Jing Wang, Andrea C. Florian, Lance R. Thomas, Joy H. Creighton, Brittany K. Matlock, David K. Flaherty, Shelly L. Lorey, Gregory C. Howard, Stephen W. Fesik, April M. Weissmiller, Qi Liu, William P. Tansey
Publikováno v:
Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
WDR5 nucleates the assembly of histone-modifying complexes and acts outside this context in a range of chromatin-centric processes. WDR5 is also a prominent target for pharmacological inhibition in cancer. Small-molecule degraders of WDR5 have been d
Autor:
John T. Benjamin, Nicholas E. Banovich, A. Christian Habermann, Peter Gulleman, Jonathan A. Kropski, Chase J. Taylor, Brittany K. Matlock, David E. Nichols, Bryce A. Schuler, Jennifer M.S. Sucre, Christopher S. Jetter, Timothy S. Blackwell, Nicholas M. Negretti, Erin J. Plosa, Susan H. Guttentag
SummaryLung organogenesis requires precisely timed shifts in the spatial organization and function of parenchymal cells, especially during the later stages of lung development. To investigate the mechanisms governing lung parenchymal dynamics during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8cf090538bc64662e0127ac2b664508
https://doi.org/10.1101/2021.01.21.427641
https://doi.org/10.1101/2021.01.21.427641