Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Brittany G. Durgin"'
Autor:
Katherine C. Wood, Brittany G. Durgin, Heidi M. Schmidt, Scott A. Hahn, Jeffrey J. Baust, Tim Bachman, Dario A. Vitturi, Samit Ghosh, Solomon F. Ofori-Acquah, Ana L. Mora, Mark T. Gladwin, Adam C. Straub
Publikováno v:
Blood Advances, Vol 3, Iss 23, Pp 4104-4116 (2019)
Abstract: Pulmonary and systemic vasculopathies are significant risk factors for early morbidity and death in patients with sickle cell disease (SCD). An underlying mechanism of SCD vasculopathy is vascular smooth muscle (VSM) nitric oxide (NO) resis
Externí odkaz:
https://doaj.org/article/b7619e205b9f4bd3ad6bf82a6e4b93ab
Autor:
Scott A. Hahn, Joseph C Galley, Brittany G Durgin, Sean D. Stocker, Edwin K. Jackson, Megan P. Miller, Adam C. Straub
Publikováno v:
British Journal of Pharmacology. 179:2490-2504
Background and purpose Reduced renal blood flow triggers activation of the renin-angiotensin-aldosterone system (RAAS) leading to renovascular hypertension. Renal vascular smooth muscle expression of the NO receptor, soluble GC (sGC), modulates the v
Autor:
Brenda McMahon, Jeffrey J. Baust, Brittany G Durgin, Adam C. Straub, Katherine C. Wood, Scott A. Hahn
Publikováno v:
J Mol Cell Cardiol
Chronic hypoxia is a major driver of cardiovascular complications, including heart failure. The nitric oxide (NO) – soluble guanylyl cyclase (sGC) – cyclic guanosine monophosphate (cGMP) pathway is integral to vascular tone maintenance. Specifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9664ddf45cb7e5cc4811d3ad50b402d5
https://europepmc.org/articles/PMC8766905/
https://europepmc.org/articles/PMC8766905/
Autor:
Brittany G Durgin, Megan Miller, Edwin K. Jackson, Joseph C Galley, Scott Hahn, Sean D. Stocker, Adam C. Straub
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Reduced renal blood flow triggers activation of the renin-angiotensin-aldosterone system (RAAS) leading to renovascular hypertension. Renal vascular smooth muscle expression of the nitric oxide (NO) receptor, soluble guanylyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f999376d050f711b2ef3cc855174e4
https://doi.org/10.22541/au.159986538.84326499
https://doi.org/10.22541/au.159986538.84326499
Publikováno v:
Hypertension. 76
In cardiovascular disease, oxidative stress can drive soluble guanylyl cyclase (sGC) heme oxidation resulting in the loss of the sGC heme (apo-sGC), the impairment of nitric oxide (NO) binding and cGMP production, and vasoconstriction. Consequently,
Publikováno v:
Hypertension. 76
Pulmonary hypertension causes increased pulmonary vascular resistance and right heart failure. Nitric oxide (NO) binds to its receptor soluble guanylyl cyclase (sGC) within vascular smooth muscle cells in its reduced heme (Fe 2+ ) form to increase in
Autor:
Solomon F. Ofori-Acquah, Jeffrey J. Baust, Mark T. Gladwin, Heidi M Schmidt, Adam C. Straub, Tim Bachman, Samit Ghosh, Ana L. Mora, Dario A. Vitturi, Katherine C. Wood, Brittany G Durgin, Scott A. Hahn
Pulmonary and systemic vasculopathies are significant risk factors for early morbidity and death in patients with sickle cell disease (SCD). An underlying mechanism of SCD vasculopathy is vascular smooth muscle (VSM) nitric oxide (NO) resistance, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58871e1b9f1e78b6b6cbbd94d84d5af
https://europepmc.org/articles/PMC6963246/
https://europepmc.org/articles/PMC6963246/
Autor:
Neha Hafeez, Peter Sandner, Scott Hahn, Heidi M Schmidt, Brittany G Durgin, Megan P. Miller, Ilka Mathar, Daniel F. Freitag, Adam C. Straub
Publikováno v:
JCI Insight. 4
Nitric oxide regulates BP by binding the reduced heme iron (Fe(2+)) in soluble guanylyl cyclase (sGC) and relaxing vascular smooth muscle cells (SMCs). We previously showed that sGC heme iron reduction (Fe(3+) → Fe(2+)) is modulated by cytochrome b
Publikováno v:
Hypertension. 74
Soluble guanylyl cyclase (sGC) heme oxidation (Fe 3+ ) leading to apo-sGC formation diminishes the ability of nitric oxide (NO) to bind sGC and generate intracellular cGMP levels needed for downstream protein kinase G activation and vessel relaxation
Autor:
Scott A. Hahn, Shuai Yuan, Joseph C Galley, Brittany G Durgin, Katherine C. Wood, Adam C. Straub, Megan P. Miller
Publikováno v:
Molecular Pharmacology
Nitric oxide (NO) stimulates soluble guanylyl cyclase (sGC) activity, leading to elevated intracellular cyclic guanosine 3',5'-monophosphate (cGMP) and subsequent vascular smooth muscle relaxation. It is known that downregulation of sGC expression at