Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Brittany F Karas"'
Autor:
Dhyanam Shukla, Brian M. Gural, Edmund S. Cauley, Namarata Battula, Shorbon Mowla, Brittany F. Karas, Llion E. Roberts, Luca Cavallo, Luka Turkalj, Sally A. Moody, Laura E. Swan, M. Chiara Manzini
Publikováno v:
Development Genes and Evolution.
One hurdle in the development of zebrafish models of human disease is the presence of multiple zebrafish orthologs resulting from whole genome duplication in teleosts. Mutations in inositol polyphosphate 5-phosphatase K (INPP5K) lead to a syndrome ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88e650034247110fa8fb0c8a6fe6399b
https://doi.org/10.1007/s00427-023-00703-z
https://doi.org/10.1007/s00427-023-00703-z
Autor:
Brittany F. Karas, Kristin R. Terez, Namarata Battula, Brian M. Gural, Kyle P. Flannery, Grace Aboussleman, Numa Mubin, M. Chiara Manzini
Biallelic mutations inProtein O-mannosyltransferase 1(POMT1) are among the most common causes of a severe group of congenital muscular dystrophies (CMDs) known as dystroglycanopathies. POMT1 is a glycosyltransferase responsible for the attachment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3013ee6e2cb2aa1b2e94b35ebfb33ff6
https://doi.org/10.1101/2022.10.15.512359
https://doi.org/10.1101/2022.10.15.512359
Autor:
Dhyanam Shukla, Brian M. Gural, Edmund S. Cauley, Llion E. Roberts, Brittany F. Karas, Luca Cavallo, Luka Turkalj, Sally A. Moody, Laura E. Swan, M. Chiara Manzini
One hurdle in the development of zebrafish models of human disease is the presence of multiple zebrafish orthologs resulting from whole genome duplication in teleosts. Mutations in Inositol polyphosphate 5-phosphatase K (INPP5K) lead to a syndrome ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39ae5dc5c18ad88dcbe73fce5ba656cb
https://doi.org/10.1101/2022.08.31.506059
https://doi.org/10.1101/2022.08.31.506059
Autor:
Brian Buckley, Keith R. Cooper, Kristin R Terez, Jordan M. Hotz, Leonor Côrte-Real, Victoria L. DiBona, Andreia Valente, Brittany F Karas, Brian M Gural
Publikováno v:
Toxicol Sci
Ruthenium is popular as a metal core for chemotherapeutics, due to versatile molecular coordination. Because new metallodrugs are synthesized at high rates, our studies included assays in zebrafish to expedite the initial evaluation as anticancer age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eedbfdff8f506488205a9fe690758ab
https://doi.org/10.1093/toxsci/kfab041
https://doi.org/10.1093/toxsci/kfab041
Autor:
Brian T. Buckley, Keith R. Cooper, Leonor Côrte-Real, Kristin R. Terez, Cathleen L. Doherty, Brittany F. Karas
Publikováno v:
J Vis Exp
Metals and metal-based compounds comprise multifarious pharmaco-active and toxicological xenobiotics. From heavy metal toxicity to chemotherapeutics, the toxicokinetics of these compounds have both historical and modern-day relevance. Zebrafish have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6852d4f97b8bd884e9fe626089eca169
https://doi.org/10.3791/63587-v
https://doi.org/10.3791/63587-v
Autor:
Cathleen Doherty, Brian Buckley, Fernanda Marques, M. Helena Garcia, Leonor Côrte-Real, Patrícia Gírio, Alexis Moreno, Andreia Valente, Pierre Falson, Keith R. Cooper, Fernando Avecilla, Brittany F Karas
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2019, 163, pp.853-863. ⟨10.1016/j.ejmech.2018.12.022⟩
European Journal of Medicinal Chemistry, Elsevier, 2019, 163, pp.853-863. ⟨10.1016/j.ejmech.2018.12.022⟩
International audience; Two new ruthenium complexes, [Ru(h 5-Cp)(PPh 3)(2,2'-bipy-4,4'-R)] þ with R ¼-CH 2 OH (Ru1) or dibiotin ester (Ru2) were synthesized and fully characterized. Both compounds were tested against two types of breast cancer cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd399c16284d8151c87ae642f1d0dd9
https://doi.org/10.1016/j.ejmech.2018.12.022
https://doi.org/10.1016/j.ejmech.2018.12.022
Publikováno v:
Aquat Toxicol
Zebrafish have gained popularity as a model organism due to their rapid, external, and transparent development, high fecundity, and gene homology with higher vertebrate models and humans. Specifically, drug discovery has had high success in the imple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f26eb204d87b1bdb0f4e5858d3be41
https://doi.org/10.1016/j.aquatox.2020.105656
https://doi.org/10.1016/j.aquatox.2020.105656
Autor:
Andreia Valente, Brian Buckley, Brittany F Karas, Cathleen Doherty, Keith R. Cooper, Leonor Côrte-Real
Publikováno v:
J Appl Toxicol
As novel metallodrugs continue to emerge, they are evaluated using models, including zebrafish, that offer unique sublethal endpoints. Testing metal-based anticancer compounds with high-throughput zebrafish toxicological assays requires analytical me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0278a4070e6720602f764f1a7b1f723
https://pubmed.ncbi.nlm.nih.gov/30963621
https://pubmed.ncbi.nlm.nih.gov/30963621
Autor:
Andreia Valente, Brittany F Karas, Ana Preto, Fernando Avecilla, Fernanda Marques, Adhan Pilon, Cathleen Doherty, Brian Buckley, Leonor Côrte-Real, Ana Rita Brás, M. Helena Garcia, Keith R. Cooper
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Prospective anticancer metallodrugs should consider target-specific components in their design in order to overcome the limitations of the current chemotherapeutics. The inclusion of vitamins, which receptors are overexpressed in many cancer cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6c9079117569de4723365011eeb4ca