Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Brittany Cross"'
Publikováno v:
Biomedicines, Vol 9, Iss 8, p 1027 (2021)
Adenosine is extensively distributed in the central and peripheral nervous systems, where it plays a key role as a neuromodulator. It has long been implicated in the pathogenesis of progressive neurogenerative disorders such as Parkinson’s disease,
Externí odkaz:
https://doaj.org/article/2ed3679c2a5f4c3aa6b8764960e01382
Publikováno v:
Biomedicines, Vol 9, Iss 1027, p 1027 (2021)
Adenosine is extensively distributed in the central and peripheral nervous systems, where it plays a key role as a neuromodulator. It has long been implicated in the pathogenesis of progressive neurogenerative disorders such as Parkinson’s disease,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb75248cb61ac9325d2951c8e4d30ee2
https://doi.org/10.3390/biomedicines9081027
https://doi.org/10.3390/biomedicines9081027
Autor:
Marigdalia K. Ramirez-Fort, Brittany Cross, Ariel Naveh, Shearwood McClelland, Melissa Mendez, Roberto Santiago, Sean S. Mahase, Jaime Matta, Ze'ev Bomzon, Christopher S. Lange
Publikováno v:
Cancer Research. 79:4430-4430
Purpose/Objective(s): TTFields are FDA-approved for the treatment of recurrent and newly diagnosed Glioblastoma (GBM) in the supratentorial brain. The EF-14 trial showed that combining TTFields with adjuvant chemo-radiation leads to a significant inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d83eaaac5e0e360add1251b4547760e3
https://doi.org/10.1158/1538-7445.am2019-4430
https://doi.org/10.1158/1538-7445.am2019-4430
Publikováno v:
Journal of Child and Family Studies. 21:1028-1040
Public policy initiatives to deliver evidence-based practices in community settings have increased the need to develop implementation feedback systems to assist program administrators adopting the practices as well as researchers who wish to continue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca7f3d79683ea92d259659beae24e3f1
https://doi.org/10.1007/s10826-012-9565-5
https://doi.org/10.1007/s10826-012-9565-5
Publikováno v:
Molecular and Cellular Biology. 31:4951-4963
MDM2 is a major regulator of p53 by acting as a ubiquitin E3 ligase. The central acidic domain and C-terminal RING domain of MDM2 are both indispensable for ubiquitination of p53. Our previous study suggested that ATM phosphorylation of MDM2 near the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e12e9f16c2d53832abc2ae1c9785f38
https://doi.org/10.1128/mcb.05553-11
https://doi.org/10.1128/mcb.05553-11
Publikováno v:
The Journal of biological chemistry. 286(18)
MDM2 regulates p53 predominantly by promoting p53 ubiquitination. However, ubiquitination-independent mechanisms of MDM2 have also been implicated. Here we show that MDM2 inhibits p53 DNA binding activity in vitro and in vivo. MDM2 binding promotes p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cea91851d1235fbd62692de7715f6e
https://pubmed.ncbi.nlm.nih.gov/21454483
https://pubmed.ncbi.nlm.nih.gov/21454483
Autor:
Dmytro Grygoryev, Marissa Connolly, Amy Kronenberg, Kelly Sandfort, Cristian Dan, Michael R. Lasarev, Brittany Cross, Mitchell S. Turker
Publikováno v:
Genes, chromosomescancer. 50(4)
Marked aneuploidy and loss of multiple chromosomes are hallmarks of cancer, but whether these events are only present in malignant cells is not known. In prior work, we showed that approximately half of spontaneous autosomal mutants isolated directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb04b34bfc5afa0e3ff5a17d4b8f494
https://pubmed.ncbi.nlm.nih.gov/21254298
https://pubmed.ncbi.nlm.nih.gov/21254298
Autor:
Lihong Chen, Zhi-Min Yuan, Thomas Jenuwein, Brittany Cross, Kenneth L. Wright, John M. Koomen, Jean-Christophe Marine, Matthew A. Smith, Aleksandra Zwolinska, Zhenyu Li, Jiandong Chen
Publikováno v:
The EMBO Journal
MDM2 is a key regulator of the p53 tumor suppressor acting primarily as an E3 ubiquitin ligase to promote its degradation. MDM2 also inhibits p53 transcriptional activity by recruiting histone deacetylase and corepressors to p53. Here, we show that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadf976ec348adaa39ff3dfe3f51fabf
https://pubmed.ncbi.nlm.nih.gov/20588255
https://pubmed.ncbi.nlm.nih.gov/20588255
Publikováno v:
Cancer Research. 71:3090-3090
MDM2 is an important regulator of p53, acting in part by promoting p53 ubiquitination. However, MDM2 has also been implicated in regulation of p53 through ubiquitination-independent mechanisms. Here we show that MDM2 inhibits p53 DNA binding activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cb59a7137a0cc9733be9381b112302f
https://doi.org/10.1158/1538-7445.am2011-3090
https://doi.org/10.1158/1538-7445.am2011-3090