Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Brittany Chao"'
Autor:
Elif Karakoc Aydine, Helen C. Su, John C. Pascall, Ann Y Park, Safa Baris, Silvia Vilarinho, Jahnavi Aluri, Aaron Morawski, Yu Zhang, Lixin Zheng, Rick P. Lifton, V. Koneti Rao, Sinan Sari, Ahmet Ozen, Helen F. Matthews, Brittany Chao, Isil Barlan, Xijin Xu, Michael Leney-Greene, Ping Jiang, Michael J. Lenardo, Geoff W. Butcher, Matthew Lynberg, Ayca Kiykim
Elucidating the molecular basis of immunodeficiency diseases is a powerful approach to discovering new immunoregulatory pathways in humans. Here we report 10 affected individuals from 4 families with a new immunodeficiency disease comprising of sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7744e76c49f30350b649da8b6037402
https://doi.org/10.1101/2021.02.22.432146
https://doi.org/10.1101/2021.02.22.432146
Autor:
Michael J. Lenardo, Chrysi Kanellopoulou, Ping Jiang, Shannon L. Meeks, Pete Lollar, Ernest T. Parker, Courtney Cox, Brittany Chao, John F. Healey, Kimberly Shafer-Weaver, Wallace Hunter Baldwin
UNLABELLED ESSENTIALS: Anti-factor VIII (FVIII) inhibitory antibody formation is a severe complication in hemophilia A therapy. We genetically engineered and characterized a mouse model with complete deletion of the F8 coding region. F8(TKO) mice exh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2025715604fb7373b0aa6f68330d46
https://europepmc.org/articles/PMC4755856/
https://europepmc.org/articles/PMC4755856/
Autor:
Michael Alexander Leney-Greene, Ann Park, Brittany Chao, Silvia Vilarinho, Helen Su, Ahmet Ozen, Michael J. Lenardo
Publikováno v:
The Journal of Immunology. 200:45.49-45.49
In this study, we harness Whole Exome Sequencing (WES) to interrogate the underlying genetic cause in a patient cohort suffering from a Mendelian disease of immune dysregulation characterized by severe lymphopenia, splenomegaly, anemia, thrombocytope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21db2d4b826dff83dcc753c2e92922f2
https://doi.org/10.4049/jimmunol.200.supp.45.49
https://doi.org/10.4049/jimmunol.200.supp.45.49
Publikováno v:
The Journal of general virology. 96(9)
Lymphocytes provide gammaherpesviruses with a self-renewing substrate for persistent infection and with transport to mucosal sites for host exit. Their role in the initial colonization of new hosts is less clear. Murid herpesvirus 4 (MuHV-4), an expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a2454fc1ec60c9750f1074966d28fc
https://pubmed.ncbi.nlm.nih.gov/25986632
https://pubmed.ncbi.nlm.nih.gov/25986632
Publikováno v:
The Journal of General Virology
Lymphocyte proliferation, mobility and longevity make them prime targets for virus infection. Myeloid cells that process and present environmental antigens to lymphocytes are consequently an important line of defence. Subcapsular sinus macrophages (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841ecbb612f2e7227f812a946d7b02f4
https://pubmed.ncbi.nlm.nih.gov/25872742
https://pubmed.ncbi.nlm.nih.gov/25872742
Autor:
Michael Alexander Leney-Greene, Ann Park, Brittany Chao, David Schwefel, Arasu Balasubramaniyam, Ahmet Ozen, Silvia Vilarinho, Aaron Morawski, Oliver Daumke, Helen Su, Michael J Lenardo
Publikováno v:
The Journal of Immunology. 198:59.4-59.4
In this study, we harness Whole Exome Sequencing (WES) to interrogate the underlying genetic cause in a patient cohort suffering from a Mendelian disease of immune dysregulation characterized by severe lymphopenia, splenomegaly, anemia, thrombocytope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88074ffa29cef3f064826b1ca088ade5
https://doi.org/10.4049/jimmunol.198.supp.59.4
https://doi.org/10.4049/jimmunol.198.supp.59.4
Autor:
Brittany Chao, Michael J. Lenardo, Lixin Zheng, Wei Lu, Yan Zhang, Valina L. Dawson, Senthilkumar S. Karuppagounder, Michele D. Allen, Ted M. Dawson, Danielle A. Springer
Publikováno v:
Nature Communications. 5
Mitophagy is a specialized form of autophagy that selectively disposes of dysfunctional mitochondria. Delineating the molecular regulation of mitophagy is of great importance because defects in this process lead to a variety of mitochondrial diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791ab82d7c9012cb8c1c754d913fea88
https://doi.org/10.1038/ncomms5930
https://doi.org/10.1038/ncomms5930
Publikováno v:
Cell Host & Microbe. (4):457-470
SummaryGamma-herpesviruses (γHVs) are widespread oncogenic pathogens that chronically infect circulating lymphocytes. How they subvert the immune check-point function of the spleen to promote persistent infection is not clear. We show that Murid Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3be84a0cfb2cbb2a4ee276b0142126c