Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Brittany Admire"'
1
Activity of trastuzumab emtansine (T-DM1) in 3D cell culture
Autor: Robert Kraft, Jean Zheng Boyer, Eslie Dennis, Gail Lewis Phillips, Penny Towne, Elizabeth Vela, Karl Garsha, Brittany Admire, Hiro Nitta
Publikováno v: Breast Cancer Research and Treatment
Background Cell spheroids and aggregates generated from three-dimensional (3D) cell culture methods are similar to in vivo tumors in terms of tissue morphology, biology, and gene expression, unlike cells grown in 2D cell cultures. Breast cancer heter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2076077709ca09221d656c1301bb0e95
http://europepmc.org/articles/PMC8233276
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2
Delta-like Protein 3 Prevalence in Small Cell Lung Cancer and DLL3 (SP347) Assay Characteristics
Autor: Richard S P Huang, Raji V Marati, Deepa Dalvi, Brittany Admire, Amy E. Hanlon Newell, Courtney Powell, B. Holmes, Ashley Streator, Ehab Elgabry, Javier Perez, Dusty Tyree
Publikováno v: Archives of pathologylaboratory medicine. 143(11)
Context.— Delta-like protein 3 (DLL3) is a protein that is implicated in the Notch pathway. Objective.— To present data on DLL3 prevalence in small cell lung cancer and staining characteristics of the VENTANA DLL3 (SP347) Assay. In addition, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3756257160284875ade4539dde113481
https://pubmed.ncbi.nlm.nih.gov/30958693
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3
Estimating the physicochemical properties of polyhalogenated aromatic and aliphatic compounds using UPPER: Part 2. Aqueous solubility, octanol solubility and octanol–water partition coefficient
Autor: Bo Lian, Samuel H. Yalkowsky, Brittany Admire
Publikováno v: Chemosphere. 119:1441-1446
The UPPER (Unified Physicochemical Property Estimation Relationships) model uses additive and non-additive parameters to estimate 20 biologically relevant properties of organic compounds. The model has been validated by Lian and Yalkowsky (2014) on a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31344cdf1937228414ad5653eeb6961
https://doi.org/10.1016/j.chemosphere.2014.10.031
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4
Abstract 29: Activity of trastuzumab emtansine (T-DM1) in 3D cell culture
Autor: Eslie Dennis, Robert Kraft, Gail Lewis Phillips, Megan Peccarelli, Brittany Admire, Karl Garsha, Andre Zamorano, Jean Z. Boyer, Penny Towne, Eric May, Hiro Nitta, Liz Vela, Scott Gill
Publikováno v: Cancer Research. 79:29-29
Introduction: Cell spheroids/aggregates generated from three dimensional (3D) cell culture methods are similar to real tumors in terms of tissue morphology, biology, and gene expression. We performed a unique 3D cell culture drug efficacy study with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d497452a73032f21bfd99b0adcfea233
https://doi.org/10.1158/1538-7445.am2019-29
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5
Predicting the Octanol Solubility of Organic Compounds
Autor: Samuel H. Yalkowsky, Brittany Admire
Publikováno v: Journal of Pharmaceutical Sciences. 102:2112-2119
The molar octanol solubility of an organic nonelectrolytes can be reasonably predicted solely from its melting point provided that its liquid (or a hypothetical super-cooled liquid) form is miscible with octanol. The aim of this work is to develop cr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98f469784808ad32c324b92219c2965
https://doi.org/10.1002/jps.23561
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8
Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology
Autor: Massimo Santoro, Wenqing Qi, Maria Luisa Moccia, Brendan Frett, Francesca Carlomagno, Zhong-Zhu Chen, Valentina De Falco, Annalisa Brescia, Hong-yu Li, Giorgia Federico, Brittany Admire
Publikováno v: Angewandte Chemie (Int. ed., Print) 54 (2015): 8717–8721. doi:10.1002/anie.201501104
info:cnr-pdr/source/autori:Frett, Brendan; Carlomagno, Francesca; Moccia, Maria Luisa; Brescia, Annalisa; Federico, Giorgia; De Falco, Valentina; Admire, Brittany; Chen, Zhongzhu; Qi, Wenqing; Santoro, Massimo; Li, Hong-yu/titolo:Fragment-Based Discovery of a Dual pan-RET%2FVEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology/doi:10.1002%2Fanie.201501104/rivista:Angewandte Chemie (Int. ed., Print)/anno:2015/pagina_da:8717/pagina_a:8721/intervallo_pagine:8717–8721/volume:54
Oncogenic conversion of the RET (rearranged during transfection) tyrosine kinase is associated with several cancers. A fragment-based chemical screen led to the identification of a novel RET inhibitor, Pz-1. Modeling and kinetic analysis identified P
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1823b8f88016a7798903fd0220bf696b
https://publications.cnr.it/doc/333140
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9
Estimating the physicochemical properties of polyhalogenated aromatic and aliphatic compounds using UPPER: part 1. Boiling point and melting point
Autor: Samuel H. Yalkowsky, Bo Lian, Brittany Admire
Publikováno v: Chemosphere. 119
The UPPER (Unified Physicochemical Property Estimation Relationships) model uses enthalpic and entropic parameters to estimate 20 biologically relevant properties of organic compounds. The model has been validated by Lian and Yalkowsky on a data set
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2b4858cf66536322ea4439521e8d3c
https://pubmed.ncbi.nlm.nih.gov/25022475
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