Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brittany A. Eckhardt"'
Autor:
Madison L. Doolittle, Brittany A. Eckhardt, Stephanie J. Vos, Sarah Grain, Jennifer L. Rowsey, Ming Ruan, Dominik Saul, Joshua N. Farr, Megan M. Weivoda, Sundeep Khosla, David G. Monroe
Publikováno v:
JBMR Plus, Vol 7, Iss 10, Pp n/a-n/a (2023)
ABSTRACT Estrogen regulates bone mass in women and men, but the underlying cellular mechanisms of estrogen action on bone remain unclear. Although both estrogen receptor (ER)α and ERβ are expressed in bone cells, ERα is the dominant receptor for s
Externí odkaz:
https://doaj.org/article/fce9a970aa3344afb432ff2b7082076c
Autor:
Jennifer L. Rowsey, Joshua N. Farr, Daniel G. Fraser, Sundeep Khosla, Brittany A. Eckhardt, Ruben Aquino-Martinez, David G. Monroe
Publikováno v:
J Periodontol
Background Coinciding with other chronic comorbidities, the prevalence of periodontal disease increases with aging. Mounting evidence has established that senescent cells accumulate at sites of age-related pathologies, where they promote "non-microbi
Autor:
Matthew T. Drake, Jolaine M. Hines, Joshua N. Farr, Ravinder J. Singh, Katherine L O'Grady, Amanda J Tweed, Olga P. Bondar, Brittany A. Eckhardt, Brianne S Thicke, Sara J. Achenbach, Tammie L Volkman, Sundeep Khosla, Elizabeth J. Atkinson
Publikováno v:
J Appl Lab Med
BackgroundAdvanced glycation end products (AGEs) are formed via the nonenzymatic glycation of sugars with amino acids. Two AGEs, Nε-(1-carboxymethyl)-L-Lysine (CML) and pentosidine, have been observed to be elevated in subjects suffering from a mult
Autor:
Brittany A. Eckhardt, Tamar Tchkonia, Jennifer L. Rowsey, Daniel G. Fraser, David G. Monroe, Joshua N. Farr, James L. Kirkland, Brianne S Thicke, Sundeep Khosla
Publikováno v:
J Bone Miner Res
Estrogen deficiency is a seminal mechanism in the pathogenesis of osteoporosis. Mounting evidence, however, establishes that cellular senescence, a fundamental mechanism that drives multiple age-related diseases, also causes osteoporosis. Recently, w
Autor:
Sundeep Khosla, Ruben Aquino-Martinez, Brittany A. Eckhardt, David G. Monroe, Daniel G. Fraser, Joshua N. Farr, Jennifer L. Rowsey
Publikováno v:
Bone
Cellular senescence is associated with inflammation and extracellular matrix tissue remodeling through the secretion of proteins termed the senescence-associated secretory phenotype (SASP). Although osteocyte senescence in older individuals in the sk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d29e3645ee6ba4f67c626ae04ab3b2
https://europepmc.org/articles/PMC6990876/
https://europepmc.org/articles/PMC6990876/
Autor:
Katherine L O'Grady, Brianne S Thicke, João F. Passos, Jennifer L. Rowsey, Olga P. Bondar, Aleksey V. Matveyenko, Brittany A. Eckhardt, David G. Monroe, Anthony B. Lagnado, Ravinder J. Singh, Sundeep Khosla, Daniel G. Fraser, Adrian Vella, Jolaine M. Hines, Joshua N. Farr, Andrew R. Thoreson, Kuntol Rakshit
Publikováno v:
JCI Insight
The worldwide prevalence of type 2 diabetes (T2D) is increasing. Despite normal to higher bone density, patients with T2D paradoxically have elevated fracture risk resulting, in part, from poor bone quality. Advanced glycation endproducts (AGEs) and
Autor:
Brianne S Thicke, Ming Ruan, Aleksey V. Matveyenko, Jennifer R. Geske, Merry Jo Oursler, Amanda J Tweed, David G. Monroe, Bart L. Clarke, Brittany A. Eckhardt, Thomas Levin Andersen, Joshua N. Farr, Chee Kian Chew, Matthew T. Drake, Sundeep Khosla, Adrian Vella, Robert A. Rizza, Elizabeth J. Atkinson, Moustapha Kassem, Louise K. McCready, Megan M. Weivoda
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Weivoda, M M, Chew, C K, Monroe, D G, Farr, J N, Atkinson, E J, Geske, J R, Eckhardt, B, Thicke, B, Ruan, M, Tweed, A J, McCready, L K, Rizza, R A, Matveyenko, A, Kassem, M, Andersen, T L, Vella, A, Drake, M T, Clarke, B L, Oursler, M J & Khosla, S 2020, ' Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism ', Nature Communications, vol. 11, 87 . https://doi.org/10.1038/s41467-019-14003-6
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Weivoda, M M, Chew, C K, Monroe, D G, Farr, J N, Atkinson, E J, Geske, J R, Eckhardt, B, Thicke, B, Ruan, M, Tweed, A J, McCready, L K, Rizza, R A, Matveyenko, A, Kassem, M, Andersen, T L, Vella, A, Drake, M T, Clarke, B L, Oursler, M J & Khosla, S 2020, ' Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism ', Nature Communications, vol. 11, 87 . https://doi.org/10.1038/s41467-019-14003-6
Bone remodeling consists of resorption by osteoclasts followed by formation by osteoblasts, and osteoclasts are a source of bone formation-stimulating factors. Here we utilize osteoclast ablation by denosumab (DMAb) and RNA-sequencing of bone biopsie