Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Britta Siekmann"'
Submicron-sized triglyceride emulsions are commonly used as a high-calorie source in parenteral nutrition and may also serve as drug carrier systems for the parenteral, even the intravenous administration of lipophilic drugs. Especially an increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::014174fe30d77e4e43f30e26d4d9e1d4
https://doi.org/10.1201/9780367810528-7
https://doi.org/10.1201/9780367810528-7
Autor:
Britta Siekmann, Kirsten Westesen
Submicron-sized oil-in-water emulsions have been clinically used for decades in parenteral nutrition and also as colloidal drug carrier systems for poorly water soluble substances. Colloidal lipid suspensions can principally be prepared by the same m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7ecb18839a489672fd9c2a1ada74fdd
https://doi.org/10.1201/9780367810528-8
https://doi.org/10.1201/9780367810528-8
Publikováno v:
European Journal of Pharmaceutical Sciences. 27:44-53
The ultrastructure of aqueous colloidal dispersions of the cubic monoolein/poloxamer 407/water phase, in particular the particle size distribution and presence of an additional vesicular fraction, highly depends on composition and preparation paramet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c678452adbf2c2416f9d429b45bc8da
https://doi.org/10.1016/j.ejps.2005.08.004
https://doi.org/10.1016/j.ejps.2005.08.004
Publikováno v:
International Journal of Pharmaceutics. 244:33-43
Dispersions of bicontinuous cubic monoglyceride–water phases, so-called ‘cubosomes’, have been proposed as parenteral sustained release delivery systems. For the present study, dispersions of monoolein-rich monoglycerides (MO), with or without
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45a8e9cf1ccffaaeed5b29adfea9871
https://doi.org/10.1016/s0378-5173(02)00298-3
https://doi.org/10.1016/s0378-5173(02)00298-3
Publikováno v:
European Journal of Pharmaceutical Sciences. 13:393-401
Clomethiazole (CMZ) was used as a model drug to be incorporated into an emulsion vehicle. The effects of drug concentration and number of homogenisation steps were evaluated using multiple linear regression. The droplet size, measured as a z-average
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c48d3a112ebfee885861b50b2717fb
https://doi.org/10.1016/s0928-0987(01)00138-5
https://doi.org/10.1016/s0928-0987(01)00138-5
Autor:
Britta Siekmann, Kirsten Westesen
Publikováno v:
International Journal of Pharmaceutics. 151:35-45
Despite the obvious similarities between colloidal lipid suspensions (solid lipid nanoparticles) and lipid o/w emulsions regarding the chemical composition and the preparation method, there are basic differences in the physicochemical behaviour of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a686b248a06b0d814c310db1cfece0bc
https://doi.org/10.1016/s0378-5173(97)04890-4
https://doi.org/10.1016/s0378-5173(97)04890-4
Autor:
Britta Siekmann, Kirsten Westesen
Publikováno v:
Pharmaceutical Research. 12:201-208
The present study describes a novel pharmaceutical formulation of coenzyme Q10, viz. submicron-sized dispersions of the substance prepared by emulsification of molten coenzyme Q10 in an aqueous phase. Photon correlation spectroscopy reveals mean diam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c90d2f30d9ce2f57818ac6a6152aa17f
https://doi.org/10.1023/a:1016270724413
https://doi.org/10.1023/a:1016270724413
Autor:
Britta Siekmann, Kirsten Westesen
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 3:159-175
The recrystallization behaviour, the time course of polymorphic transitions, and the degree of crystallinity of melthomogenized glyceride nanoparticle dispersions were investigated by differential scanning calorimetry (DSC). The results suggest that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2203b7f99cadfaad6f95c98628b5d2e
https://doi.org/10.1016/0927-7765(94)80063-4
https://doi.org/10.1016/0927-7765(94)80063-4
Publikováno v:
International Journal of Pharmaceutics. 93:189-199
Submicron-sized parenteral drug carrier systems based on lipids solid at room temperature in the bulk phase were prepared by high pressure homogenization of an emulsion of molten lipids in an aqueous phase. Phospholipids, bile salts and block copolym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d34c257e59a849a2bea8512fd863181
https://doi.org/10.1016/0378-5173(93)90177-h
https://doi.org/10.1016/0378-5173(93)90177-h
Publikováno v:
Trends in Colloid and Interface Science VII ISBN: 9783798509559
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7f77c1e018ab9069467a3e8c9be9633
https://doi.org/10.1007/bfb0118612
https://doi.org/10.1007/bfb0118612