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pro vyhledávání: '"Britta Schlund"'
Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation
Autor:
Britta Schlund, Sonja Gebhard, Takako Hattori, Andreas Hess, Klaus von der Mark, Svitlana Golovchenko, Christine Hartmann, Matthias Gebhardt, Friederike Pausch
Publikováno v:
Bone. 55:102-112
In order to elucidate the role of β-catenin in hypertrophic cartilage zone of the growth plate, we deleted the β-catenin gene ctnnb1 specifically from hypertrophic chondrocytes by mating ctnnb1 fl/fl mice with BAC-Col10a1-Cre -deleter mice. Surp
Autor:
Michael R. Bösl, Benoit de Crombrugghe, Eva Bauer, Helga von der Mark, Britta Schlund, Takako Hattori, Sonja Gebhard, Cordula Surmann-Schmitt, Andreas Hess, Friederike Pausch, Catharina Müller, Klaus von der Mark
Publikováno v:
Development. 137:901-911
SOX9 is a transcription factor of the SRY family that regulates sex determination, cartilage development and numerous other developmental events. In the foetal growth plate, Sox9 is highly expressed in chondrocytes of the proliferating and prehypertr
Autor:
Michael R. Bösl, Takako Hattori, Klaus von der Mark, Britta Schlund, Eva Bauer, Benoit de Crombrugghe, Sonja Gebhard
Publikováno v:
Matrix Biology. 27:693-699
Previously we have shown that insertion of a LacZ reporter gene into the Col10a1 gene in the context of a bacterial artificial chromosome (BAC) drives strong and specific expression of LacZ in hypertrophic cartilage of transgenic mice [Gebhard S., Ha
Autor:
Nadia Adam, Klaus von der Mark, Eva Bauer, Britta Schlund, Benoit de Crombrugghe, Ernst Pöschl, Takako Hattori, Sonja Gebhard, Michael R. Bösl
Publikováno v:
Histochemistry and Cell Biology
During endochondral ossification hypertrophic chondrocytes in the growth plate of fetal long bones, ribs and vertebrae play a key role in preparing growth plate cartilage for replacement by bone. In order to establish a reporter gene mouse to facilit