Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Britta Lipinski"'
Autor:
Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka, Katja Klausz
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTNatural killer (NK) cells emerged as a promising effector population that can be harnessed for anti-tumor therapy. In this work, we constructed NK cell engagers (NKCEs) based on NKp30-targeting single domain antibodies (sdAbs) that redirect t
Externí odkaz:
https://doaj.org/article/dab9f66e27944e228e065c4ff4d03f51
Autor:
Britta Lipinski, Laura Unmuth, Paul Arras, Stefan Becker, Christina Bauer, Lars Toleikis, Simon Krah, Achim Doerner, Desislava Yanakieva, Ammelie Svea Boje, Katja Klausz, Matthias Peipp, Vanessa Siegmund, Andreas Evers, Harald Kolmar, Lukas Pekar, Stefan Zielonka
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTHere, we generated bispecific antibody (bsAb) derivatives that mimic the function of interleukin (IL)-18 based on single domain antibodies (sdAbs) specific to IL-18 Rα and IL-18 Rβ. For this, camelids were immunized, followed by yeast surfa
Externí odkaz:
https://doaj.org/article/7e0581bda58843b2a64abbd81a6ee1ef
Publikováno v:
Molecules, Vol 29, Iss 5, p 1140 (2024)
Valued for their ability to rapidly kill multiple tumor cells in succession as well as their favorable safety profile, NK cells are of increasing interest in the field of immunotherapy. As their cytotoxic activity is controlled by a complex network o
Externí odkaz:
https://doaj.org/article/68cfee385c1a47cf8094176669399c9c
Autor:
Katja Klausz, Lukas Pekar, Ammelie Svea Boje, Carina Lynn Gehlert, Steffen Krohn, Tushar Gupta, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Britta Lipinski, Lars Toleikis, Sven Poetzsch, Brian Rabinovich, Matthias Peipp, Stefan Zielonka
Publikováno v:
The Journal of Immunology. 209:1724-1735
In this work, we have generated novel Fc-comprising NK cell engagers (NKCEs) that bridge human NKp30 on NK cells to human epidermal growth factor receptor (EGFR) on tumor cells. Camelid-derived VHH single-domain Abs specific for human NKp30 and a hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56b42a194d0d8ebf19aa29d6f2fda5a
https://doi.org/10.4049/jimmunol.2100970
https://doi.org/10.4049/jimmunol.2100970
Autor:
Britta Lipinski, Paul Arras, Lukas Pekar, Daniel Klewinghaus, Ammelie Svea Boje, Simon Krah, Jasmin Zimmermann, Katja Klausz, Matthias Peipp, Vanessa Siegmund, Andreas Evers, Stefan Zielonka
Publikováno v:
Protein Science. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e053be5c6d272ebe93722d56a59f7d6
https://doi.org/10.1002/pro.4593
https://doi.org/10.1002/pro.4593